Novel Spatially Asymmetric Copper Bismuthate‐Mediated Augmentation of Energy Conversion to Realize “Three‐Step” Tumor Suppression

Advanced Science, Год журнала: 2024, Номер 11(25)

Опубликована: Апрель 23, 2024

The generally undesirable bandgap and electron-hole complexation of inorganic sonosensitizers limit the efficiency reactive oxygen species (ROS) generation, affecting effectiveness sonodynamic therapy (SDT). Comparatively, novel polyvinylpyrrolidone-modified copper bismuthate (PCBO) are manufactured for a "three-step" SDT promotion. In brief, first, strong hybridization between Bi 6s O 2p orbitals in PCBO narrows (1.83 eV), facilitating rapid transfer charge carriers. Additionally, nonequivalent [CuO

Язык: Английский

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Sono-blasting Triggered Cascading-Amplification of Oxidative Stress for Enhanced Interventional Therapy of Hepatocellular Carcinoma

Nano Letters, Год журнала: 2024, Номер 24(29), С. 8996 - 9003

Опубликована: Июль 12, 2024

Interventional therapy is widely regarded as a highly promising treatment approach for nonsurgical liver cancer. However, the development of drug resistance and tolerance to hypoxic environments after embolization can lead increased angiogenesis, enhanced tumor cell stemness, greater invasiveness, resulting in metastasis recurrence. To address these challenges, novel involving use lecithin DSPE-PEG comodified Ca

Язык: Английский

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Emerging Piezoelectric Sonosensitizer for ROS-Driven Sonodynamic Cancer Therapy

Inorganics, Год журнала: 2025, Номер 13(3), С. 71 - 71

Опубликована: Фев. 26, 2025

As a non-invasive modality, sonodynamic therapy (SDT) offers several advantages in cancer treatment, including deep tissue penetration and precise spatiotemporal control, resulting from the interplay between low-intensity ultrasound sonosensitizers. Piezoelectric materials, known for their remarkable capacity of interconversion mechanical electrical energy, have garnered considerable attention biomedical applications, which can serve as pivotal sonosensitizers SDT. These materials generate internal electric fields via ultrasound-induced deformation, modulates alteration charge carriers, thereby initiating surface redox reactions to reactive oxygen species (ROS) realizing therapeutic efficacy This review provides an in-depth exploration piezoelectric utilized SDT, with particular emphasis on recent innovations, elucidation underlying mechanisms, optimization strategies advanced materials. Furthermore, incorporation immunotherapy, photodynamic, chemodynamic, chemotherapy is explored, emphasizing potential enhance outcomes. By examining basic principles effect its contributions this sheds light promising applications oncology. It also highlights future directions improving these expanding clinical utility tumor therapy.

Язык: Английский

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Pt–PtTe₂ Nanoparticles with Heterojunction-Based Accelerated Electron Transfer for Efficient Tumor Therapy

ACS Applied Nano Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 15, 2025

Язык: Английский

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Ag-Doped SnSe Nanosheets for Enhanced NIR-II Light-Induced Apoptosis

ACS Applied Nano Materials, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 22, 2024

Triple-negative breast cancer (TNBC) is one of the most aggressive and challenging subtypes with limited treatment options poor prognosis. To overcome these obstacles, Ag-doped SnSe (ASS) nanosheets were used as photonic hyperthermia agents for treating TNBC. ASS featured a high photothermal-conversion efficiency photon effect. Additionally, biosafety assessments, including hemolysis assays histopathological analysis, confirmed that was biosafety. These findings suggest ASS, in synergy second near-infrared biowindow (NIR-II) light irradiation, offers noninvasive, effective, safe therapeutic strategy This innovative approach exemplifies evolving landscape TNBC treatment, where technology biology converge to offer more precise personalized therapies.

Язык: Английский

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Interface‐Engineered Cu_xO@Bi₂MoO₆ Heterojunctions to Inhibit Piezoelectric Screening Effect and Promote Double‐Nanozyme Catalysis for Antibacterial Treatment

Small, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 12, 2024

Sonodynamic therapy is confronted with the low acoustic efficiency of sonosensitizers, and nanozymes are accompanied by intrinsic catalytic activity. Herein, to increase piezopotential N-type piezoelectric semiconductors, P-N heterojunction designed inhibit screening effect (PSE) electron utilization enhance nanozyme P-type Cu

Язык: Английский

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