Polypropylene Mesh Coated with Dual Cross‐Linked Hyaluronic Acid/Polyvinyl Alcohol Composite Hydrogel with Antiadhesion and Angiogenesis Properties for Abdominal Wall Repair

Advanced Materials Technologies, Год журнала: 2025, Номер unknown

Опубликована: Янв. 22, 2025

Abstract Development of an antiadhesion polypropylene (PP) mesh in hernia repair is a recognized need because its efficacy limited by severe abdominal adhesions. The porous structure PP can facilitate the integration between prosthetic material and tissue promote wall defect. Herein, composite hydrogel coating composed polyvinyl alcohol (PVA) hyaluronic acid methacrylate (HAMA) fabricated on surface through ultraviolet photopolymerization combined with freezing–thawing method. resulted coated retain 43.33% pore this way. In vitro tests proved as‐prepared exhibit excellent hydrophilicity biocompatibility. Meanwhile, shows good stability phosphate buffered saline medium. After implantation rat defect model, modified effectively prevents formation adhesion reducing inflammatory response suppressing excessive deposition collagen fiber. Immunohistochemical staining results demonstrate that not only decrease expression IL‐6, TNF‐α, CD68 but also CD31. Thus, type preventing postoperative adhesions improving angiogenesis may be promising clinical material.

Язык: Английский

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Light‐Operated Transient Unilateral Adhesive Hydrogel for Comprehensive Prevention of Postoperative Adhesions

Advanced Science, Год журнала: 2024, Номер 11(32)

Опубликована: Июнь 25, 2024

Abstract Dislocation of anti‐adhesion materials, non‐specific tissue adhesion, and the induction secondary fibrinolysis disorders are main challenges faced by postoperative materials. Herein, a self‐leveling transient unilateral adhesive hydrogel is custom‐designed to conquer these with theoretically calculated dual‐step tailored gellan gum (GG) as sole agent. First, maximum gelation temperature GG lowered from 42–25 °C through controlled perturbation intra‐ inter‐molecular hydrogen bonds, which achieved employing methacrylic anhydride “hydrogen bond's perturbator” form methacrylate (MeGG). Second, “self‐leveling” injectability wound shape adaptably endowed formation borate‐diol complexed MeGG (BMeGG). Finally, tissue‐adhesive (BMeGG‐H) barrier prepared photo‐controlled cross‐linking reactive alkenyl groups. This degradable demonstrates favorable rheological properties, light‐controlled adhesion biocompatibility, anti‐fibrin anti‐cell properties in vitro. Comprehensive regulation balance toward non‐adhesion conformed rat model after intra‐abdominal surgery via anti‐autoinflammatory response, intestinal wall integrity repair, Tissue plasminogen activator (t‐PA) inhibitor‐1 (PAI‐1) adjustment. Notably, 14 th day effective rate 100%, indicating its significant potential clinical applications for anti‐adhesion.

Язык: Английский

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Hydrogel adhesives for tissue recovery

Advances in Colloid and Interface Science, Год журнала: 2025, Номер unknown, С. 103496 - 103496

Опубликована: Март 1, 2025

Язык: Английский

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Injectable polyphenol hydrogel prevents peritoneal adhesion intensified by intraperitoneal microbial infection

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 163134 - 163134

Опубликована: Апрель 1, 2025

Язык: Английский

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Advanced hydrogels for pancreatic fistula prevention, management and treatment: requirements, advances, and prospects

Chemical Engineering Journal, Год журнала: 2024, Номер unknown, С. 156087 - 156087

Опубликована: Сен. 1, 2024

Язык: Английский

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