Cited by Advanced hydrogels for pancreatic fistula prevention, management and treatment: requirements, advances, and prospects

Polypropylene Mesh Coated with Dual Cross‐Linked Hyaluronic Acid/Polyvinyl Alcohol Composite Hydrogel with Antiadhesion and Angiogenesis Properties for Abdominal Wall Repair DOI

Dandan Wei,

Guanhua Jiao,

Yinghua Tao

et al.

Advanced Materials Technologies, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Abstract Development of an antiadhesion polypropylene (PP) mesh in hernia repair is a recognized need because its efficacy limited by severe abdominal adhesions. The porous structure PP can facilitate the integration between prosthetic material and tissue promote wall defect. Herein, composite hydrogel coating composed polyvinyl alcohol (PVA) hyaluronic acid methacrylate (HAMA) fabricated on surface through ultraviolet photopolymerization combined with freezing–thawing method. resulted coated retain 43.33% pore this way. In vitro tests proved as‐prepared exhibit excellent hydrophilicity biocompatibility. Meanwhile, shows good stability phosphate buffered saline medium. After implantation rat defect model, modified effectively prevents formation adhesion reducing inflammatory response suppressing excessive deposition collagen fiber. Immunohistochemical staining results demonstrate that not only decrease expression IL‐6, TNF‐α, CD68 but also CD31. Thus, type preventing postoperative adhesions improving angiogenesis may be promising clinical material.

Language: Английский

Citations

Light‐Operated Transient Unilateral Adhesive Hydrogel for Comprehensive Prevention of Postoperative Adhesions DOI

Furong Cui,

Shihong Shen,

Xiaoxuan Ma

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(32)

Published: June 25, 2024

Abstract Dislocation of anti‐adhesion materials, non‐specific tissue adhesion, and the induction secondary fibrinolysis disorders are main challenges faced by postoperative materials. Herein, a self‐leveling transient unilateral adhesive hydrogel is custom‐designed to conquer these with theoretically calculated dual‐step tailored gellan gum (GG) as sole agent. First, maximum gelation temperature GG lowered from 42–25 °C through controlled perturbation intra‐ inter‐molecular hydrogen bonds, which achieved employing methacrylic anhydride “hydrogen bond's perturbator” form methacrylate (MeGG). Second, “self‐leveling” injectability wound shape adaptably endowed formation borate‐diol complexed MeGG (BMeGG). Finally, tissue‐adhesive (BMeGG‐H) barrier prepared photo‐controlled cross‐linking reactive alkenyl groups. This degradable demonstrates favorable rheological properties, light‐controlled adhesion biocompatibility, anti‐fibrin anti‐cell properties in vitro. Comprehensive regulation balance toward non‐adhesion conformed rat model after intra‐abdominal surgery via anti‐autoinflammatory response, intestinal wall integrity repair, Tissue plasminogen activator (t‐PA) inhibitor‐1 (PAI‐1) adjustment. Notably, 14 th day effective rate 100%, indicating its significant potential clinical applications for anti‐adhesion.

Language: Английский

Citations

Hydrogel adhesives for tissue recovery DOI

Haohao Cui,

Jinguo Li

Advances in Colloid and Interface Science, Journal Year: 2025, Volume and Issue: unknown, P. 103496 - 103496

Published: March 1, 2025

Language: Английский

Citations

Injectable polyphenol hydrogel prevents peritoneal adhesion intensified by intraperitoneal microbial infection DOI

Jinpeng Wen, Yunhe Zheng, Jiangchuan He

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 163134 - 163134

Published: April 1, 2025

Language: Английский

Citations

Advanced hydrogels for pancreatic fistula prevention, management and treatment: requirements, advances, and prospects DOI

Yajuan He, Shihong Shen, Sen Zhang

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 156087 - 156087

Published: Sept. 1, 2024

Language: Английский

Citations