Angewandte Chemie,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 10, 2024
Abstract
Covalent
organic
frameworks
(COFs)
have
garnered
growing
interest
in
the
field
of
biomedicine;
however,
their
application
sonodynamic
therapy
remains
underexplored
due
to
limited
understanding
intrinsic
activity
and
structure–property
relationships.
Here,
we
present
a
pore
wall
chemistry
modulation
strategy
for
empowering
two‐dimensional
(2D)
COF
heterojunctions
through
situ
growth
COFs
on
bismuth
oxycarbonate
nanosheets
(B
NSs).
Compared
negligible
effects
observed
pristine
B
NSs,
2D
heterojunction
with
vinyl‐decorated
walls
demonstrates
3.6‐fold
enhancement
sonocatalytic
singlet
oxygen
generation.
This
performance
also
significantly
outperforms
that
isoreticular
functionalized
methoxy
or
non‐substituted
groups.
Mechanistic
studies
reveal
vinyl
groups
B@COF
(BC)
facilitate
separation
transfer
charge
carriers
while
enhancing
adsorption
molecules.
Furthermore,
peroxymonosulfate
(PMS)
loading
into
porous
boosts
therapeutic
efficacy
antitumor
nanotherapy
via
dual
oxidative
species
These
findings
underscore
critical
role
modulating
properties
COFs,
advance
development
COF‐based
sonosensitizers
pro‐oxidative
applications.
Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 10, 2024
Glioblastoma
multiforme
(GBM)
is
the
most
common
primary
malignant
brain
tumor
and
known
for
its
challenging
prognosis.
Sonodynamic
therapy
(SDT)
an
innovative
therapeutic
approach
that
shows
promise
in
elimination
by
activating
sonosensitizers
with
low-intensity
ultrasound.
In
this
study,
a
novel
sonosensitizer
synthesized
using
Cu-doped
carbon
dots
(Cu-CDs)
sonodynamic
treatment
of
GBM.
Doping
copper
transforms
into
p-n
type
semiconductor
having
bandgap
1.58
eV,
prolonged
lifespan
10.7
µs,
improved
electron-
hole-separation
efficiency.
The
effect
efficiency
enhanced.
Western
blot
analysis
reveals
Cu-CDs
induces
biological
response
leading
to
cell
death,
termed
as
cuproptosis.
Specifically,
upregulate
dihydrosulfanyl
transacetylase
expression,
thereby
establishing
synergistic
against
death
when
combined
SDT.
Furthermore,
exhibit
excellent
permeability
through
blood-brain
barrier
potent
anti-tumor
activity.
Importantly,
effectively
impede
growth
glioblastoma
tumors
prolong
survival
mice
bearing
these
tumors.
This
study
provides
support
application
carbon-based
nanomaterials
therapy.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 9, 2025
Abstract
The
development
of
efficient
therapeutic
strategies
to
promote
ferroptotic
cell
death
offers
significant
potential
for
hepatocellular
carcinoma
(HCC)
treatment.
Herein,
this
study
presents
an
HCC‐targeted
nanoplatform
that
integrates
bimetallic
FeMoO
4
nanoparticles
with
CO‐releasing
molecules,
and
further
camouflaged
SP94
peptide‐modified
macrophage
membrane
enhanced
ferroptosis‐driven
multi‐modal
therapy
HCC.
Leveraging
the
multi‐enzyme
activities
multivalent
metallic
elements,
not
only
decomposes
H
2
O
generate
oxygen
alleviate
tumor
hypoxia
but
also
depletes
glutathione
inactivate
peroxides
4,
which
amplify
sonodynamic
under
ultrasound
(US)
irradiation.
Meanwhile,
catalyzes
Fenton
reaction
produce
hydroxyl
radicals
chemodynamic
therapy.
Elevated
intracellular
reactive
species
trigger
cascade
release
CO,
leading
lethal
lipid
peroxidation
enhancing
ferroptosis‐mediated
This
demonstrates
robust
anti‐tumor
efficacy
US
irradiation
favorable
biosafety
in
both
subcutaneous
orthotopic
HCC
models,
representing
a
promising
approach
Additionally,
findings
offer
new
insights
into
microenvironment
modulation
optimize
US‐triggered
cancer
Journal of Materials Chemistry B,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
This
review
discusses
the
recent
developments
in
copper-based
nanomaterials
that
utilize
copper-induced
cell
death,
categorized
by
materials
systems,
while
highlighting
limitations
of
current
cuproptosis
related
nanomaterials.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 10, 2024
Abstract
Covalent
organic
frameworks
(COFs)
have
garnered
growing
interest
in
the
field
of
biomedicine;
however,
their
application
sonodynamic
therapy
remains
underexplored
due
to
limited
understanding
intrinsic
activity
and
structure–property
relationships.
Here,
we
present
a
pore
wall
chemistry
modulation
strategy
for
empowering
two‐dimensional
(2D)
COF
heterojunctions
through
situ
growth
COFs
on
bismuth
oxycarbonate
nanosheets
(B
NSs).
Compared
negligible
effects
observed
pristine
B
NSs,
2D
heterojunction
with
vinyl‐decorated
walls
demonstrates
3.6‐fold
enhancement
sonocatalytic
singlet
oxygen
generation.
This
performance
also
significantly
outperforms
that
isoreticular
functionalized
methoxy
or
non‐substituted
groups.
Mechanistic
studies
reveal
vinyl
groups
B@COF
(BC)
facilitate
separation
transfer
charge
carriers
while
enhancing
adsorption
molecules.
Furthermore,
peroxymonosulfate
(PMS)
loading
into
porous
boosts
therapeutic
efficacy
antitumor
nanotherapy
via
dual
oxidative
species
These
findings
underscore
critical
role
modulating
properties
COFs,
advance
development
COF‐based
sonosensitizers
pro‐oxidative
applications.
ABSTRACT
Carbon
quantum
dots
(CQDs)
represent
a
rapidly
emerging
class
of
nanomaterials
with
significant
potential
in
biomedical
applications
due
to
their
tunable
fluorescence,
high
biocompatibility,
and
versatile
functionalization.
This
review
focuses
on
the
recent
progress
utilizing
CQDs
for
drug
delivery,
bioimaging,
biosensing,
cancer
therapy.
With
unique
optical
properties,
such
as
yield,
photostability,
enable
precise
bioimaging
sensitive
biosensing.
Their
small
size,
ease
surface
functionalization
allow
development
targeted
delivery
systems,
enhancing
therapeutic
precision
minimizing
side
effects.
In
therapy,
have
shown
photodynamic
photothermal
treatments
by
generating
reactive
oxygen
species
under
light
exposure,
selectively
targeting
cells
while
sparing
healthy
tissues.
Furthermore,
CQDs’
ability
penetrate
biological
barriers
including
blood–brain
barrier
opens
new
possibilities
delivering
agents
hard‐to‐reach
areas,
tumors
or
diseased
However,
challenges
optimizing
synthesis,
ensuring
long‐term
stability,
addressing
safety
concerns
environments
remain
critical
hurdles.
discusses
current
efforts
overcome
these
improve
CQD
performance
clinical
settings,
scalable
production
methods
enhanced
biocompatibility.
As
research
progresses,
are
expected
play
an
important
role
improving
healthcare
offering
more
treatment
options
contributing
advancements
personalized
medicine.
Current Issues in Molecular Biology,
Год журнала:
2024,
Номер
46(12), С. 14324 - 14350
Опубликована: Дек. 19, 2024
Glioblastoma
multiforme
(GBM)
is
one
of
the
most
aggressive
and
difficult-to-treat
brain
tumors,
with
a
poor
prognosis
due
to
its
high
resistance
conventional
therapies.
Current
treatment
options,
including
surgical
resection,
radiotherapy,
chemotherapy,
have
limited
effectiveness
in
improving
long-term
survival.
Despite
emergence
new
therapies,
monotherapy
approaches
not
shown
significant
improvements,
highlighting
need
for
innovative
therapeutic
strategies.
Combination
therapies
appear
be
promising
solution,
as
they
target
multiple
molecular
pathways
involved
GBM
progression.
One
area
growing
interest
incorporation
phytotherapy
micotherapy
complementary
treatments,
which
offer
potential
benefits
their
anti-tumor,
anti-inflammatory,
immunomodulatory
properties.
This
review
examines
current
challenges
treatment,
discusses
combination
highlights
role
integrative
options
management.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2025,
Номер
13
Опубликована: Март 20, 2025
Introduction
Sonodynamic
therapy
(SDT)
is
an
innovative
way
to
treat
tumors
by
activating
sonosensitizers
via
ultrasound
(US).
The
development
of
with
high
sonodynamic
activity
the
key
promote
clinical
application
SDT.
Methods
In
this
study,
a
novel
sonosensitizer,
La
2
(WO
4
)
3
/CuWO
composite
LC-10,
was
prepared
two-step
hydrothermal
method
and
characterized.
addition,
antitumor
LC-10
investigated
using
u251
glioma
cells
as
model.
Results
Discussion
results
showed
that
compared
CuWO
,
had
better
activity,
good
biosafety
at
concentrations
below
50
μg/mL.
After
formed
composite,
recombination
electron-hole
(
e
−
–
h
+
pairs
were
effectively
inhibited,
more
strongly
oxidizing
ROS
produced,
inducing
apoptosis
cells.
which,
singlet
oxygen
1
O
hydroxyl
radical
(·OH),
especially
production
⋅OH,
played
important
role
in
mediated
SDT
process.
study
would
offer
foundation
for
design
base
nano-sonosensitizers
its
further
antitumor.
it
also
provided
new
strategy
excellent
activity.
