Oxygen-Independent Sulfate Radical and Fe2+-Modified Implants for Fast Sterilization and Osseointegration of Infectious Bone Defects DOI
Ziyou Wang, Ying Huang, Shuai He

и другие.

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Май 11, 2025

Currently, emerging dynamic therapy has gradually become a frequently used strategy for treating infectious bone defects via rise in reactive oxygen species (ROS) levels, which can bring about oxidative harm to bacteria. However, ROS be generated only under conditions of exogenous energy, limited by energy penetration or dependence on the existence internal O2/H2O2. Thus, we designed Na2S2O8-decorated polyetheretherketone implants activated Fe2+ infected defects. In vitro experiments show that they generate sulfate radical (·SO4-) and hydroxyl (·OH) without O2/H2O2 existence, effectively killing Additionally, released enters bacteria triggers ferroptosis-like death lipid peroxidation. vivo achieve an ideal effect integration through high-efficiency bactericidal enhanced osteogenic activity. As envisioned, our proposed offers promising approach halt refractory infection tissue autonomously catalyzing storms death, facilitating bone-defect recovery.

Язык: Английский

Ultrasound-enhanced dual-responsive bismuth nanocatalysts for alleviating tumor hypoxia and promoting breast cancer sonodynamic-immunotherapy DOI
Junjie Pan, Hong Qian, Jiajia Zheng

и другие.

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160292 - 160292

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

1
Safe-by-design strategies towards bismuth-based nanomaterials in tumor diagnosis and therapy DOI
Xiaoyu Zhang,

Fene Gao,

Yizhi Dai

и другие.

Nano Today, Год журнала: 2025, Номер 62, С. 102714 - 102714

Опубликована: Март 15, 2025

Язык: Английский

Процитировано

1
Narrow-Bandgap Iridium(III)-C3N5 Nanocomplex as an Oxygen Self-Sufficient Piezo-Sonosensitizer for Hypoxic Tumor Sonodynamic Immunotherapy DOI
Xianbo Wu, Jinzhe Liang, Jun Shu

и другие.

Journal of the American Chemical Society, Год журнала: 2025, Номер unknown

Опубликована: Апрель 28, 2025

Low immunogenicity and insufficient infiltration of immune cells are the main factors affecting therapeutic efficacy melanoma immunotherapy. Ultrasound-triggered sonodynamic therapy (SDT) based on piezoelectric materials has attracted substantial attention due to its high efficiency catalytic generation reactive oxygen species (ROS) induce immunogenic cell death (ICD). However, hypoxic environment in solid tumors hinders limits SDT effect. Herein, we construct a novel Ir-C3N5 nanocomplex that uses nitrogen-rich carbon nitride (C3N5) nanosheets as nanoligands Ir(tpy)Cl3 precursor. The newly formed exhibits narrowed band gap an enlarged dipole moment, resulting better electron-hole pair separation bending, contributing ROS burst upon ultrasonic activation. In addition, Ir(III) enables C3N5 catalyze degradation H2O2 O2, alleviating tumor hypoxia reinforcing efficacy. Mechanistically, by catalysis, can target lysosomes trigger autophagy inhibition caused lysosome rupture evoke pyroptosis. More importantly, cleaved caspase-1/GSDMD-N pyroptosis pathway activated was associated with ICD, effectively initiating innate adaptive immunity body for suppressing metastasis relapse.

Язык: Английский

Процитировано

0
Ultrasound-responsive nanoweapons: covalent organic frameworks for cancer sonodynamic therapy DOI
Yu Shrike Zhang, Chunyuan Hou, Bin Zhu

и другие.

Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Sonodynamic therapy (SDT), characterized by its non-invasiveness, low toxicity, and deep tissue penetration, has emerged as a promising therapeutic modality for anticancer treatments. Recently, covalent organic frameworks (COFs) have garnered significant attention in the SDT realm powerful versatile toolbox. Notably, COF-based achieved many encouraging outcomes owing to remarkable potential of COFs, volume related research experienced continuous growth. Therefore, we strive provide timely comprehensive review that thoroughly summarizes advancements SDT. This begins with concise yet summary ultrasonic cavitation sonodynamic effects, elucidating fundamental principles mechanisms Subsequently, it delves into chemistry examining intricate structure designs, various types linkages, diverse synthetic methods. The primary focus this is summarize sonosensitizers, including construction strategies product properties. More importantly, role COFs combined therapies described detail, aiming highlight advantages COF-enhanced synergistic Finally, points out current challenges future opportunities rapidly evolving field. Overall, deliberations overviews sonosensitizers are expected facilitate advancements, leading early-stage clinical benefits patients.

Язык: Английский

Процитировано

0
Oxygen-Independent Sulfate Radical and Fe2+-Modified Implants for Fast Sterilization and Osseointegration of Infectious Bone Defects DOI
Ziyou Wang, Ying Huang, Shuai He

и другие.

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Май 11, 2025

Currently, emerging dynamic therapy has gradually become a frequently used strategy for treating infectious bone defects via rise in reactive oxygen species (ROS) levels, which can bring about oxidative harm to bacteria. However, ROS be generated only under conditions of exogenous energy, limited by energy penetration or dependence on the existence internal O2/H2O2. Thus, we designed Na2S2O8-decorated polyetheretherketone implants activated Fe2+ infected defects. In vitro experiments show that they generate sulfate radical (·SO4-) and hydroxyl (·OH) without O2/H2O2 existence, effectively killing Additionally, released enters bacteria triggers ferroptosis-like death lipid peroxidation. vivo achieve an ideal effect integration through high-efficiency bactericidal enhanced osteogenic activity. As envisioned, our proposed offers promising approach halt refractory infection tissue autonomously catalyzing storms death, facilitating bone-defect recovery.

Язык: Английский

Процитировано

0