Fundamental Research, Год журнала: 2025, Номер unknown
Опубликована: Май 1, 2025
Язык: Английский
Cells, Год журнала: 2025, Номер 14(5), С. 370 - 370
Опубликована: Март 3, 2025
Terahertz (THz) waves, a novel type of radiation with quantum and electronic properties, have attracted increasing attention for their effects on the nervous system. Spatial working memory, critical component higher cognitive function, is coordinated by brain regions such as infralimbic cortex (IL) region medial prefrontal ventral cornu ammonis 1 (vCA1) hippocampus. However, regulatory THz waves spatial memory underlying mechanisms remain unclear. In this study, 0.152 glutamatergic neuronal activity related were investigated in cell, slice, mouse models. Cellular experiments revealed that exposure 60 min significantly increased intrinsic excitability primary hippocampal neurons, enhanced neuron activity, upregulated expression molecules involved glutamate metabolism. slice experiments, markedly elevated promoted synaptic plasticity, transmission within IL vCA1 regions. Molecular dynamics simulations found could inhibit ion transport function receptors. Moreover, Y-maze tests demonstrated mice exposed to exhibited improved memory. Multiomics analyses indicated induce changes chromatin accessibility increase proportion excitatory neurons. These findings suggested potentially through modifications proportions.
Язык: Английский
Процитировано
0
Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Год журнала: 2025, Номер unknown, С. 126039 - 126039
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
PhotoniX, Год журнала: 2025, Номер 6(1)
Опубликована: Апрель 1, 2025
Abstract Neurite outgrowth and synapse formation constitute the cellular basis for establishment plasticity of neural networks, crucially involved in cognitive functions. However, techniques currently available to effectively specifically modulate these processes remain limited. In this work, we propose a non-drug non-thermal terahertz (THz) photon modulation approach that enhances neuronal growth synaptogenesis. Frequency screening experiments show 34.5 THz stimulation could promote neurite elongation postsynaptic density protein 95 (PSD95) expression by 26.0% rat hippocampal neurons. Subsequent reveal an upregulation cyclic adenosine monophosphate (cAMP) signaling pathway adenylyl cyclase type 1 (AC1) activity after irradiation. Molecular dynamics simulations suggest photons binding between AC1 ligand, accelerating cAMP generation. vivo further confirm increase levels dendritic spine stimulation, accompanied significant improvement performance. Overall, our results as effective specific method neuromodulation, promising future applications treatment dysfunction.
Язык: Английский
Процитировано
0
Springer proceedings in physics, Год журнала: 2025, Номер unknown, С. 361 - 366
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Springer proceedings in physics, Год журнала: 2025, Номер unknown, С. 103 - 108
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Springer proceedings in physics, Год журнала: 2025, Номер unknown, С. 51 - 56
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Springer proceedings in physics, Год журнала: 2025, Номер unknown, С. 244 - 250
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Springer proceedings in physics, Год журнала: 2025, Номер unknown, С. 342 - 346
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Springer proceedings in physics, Год журнала: 2025, Номер unknown, С. 278 - 284
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Springer proceedings in physics, Год журнала: 2025, Номер unknown, С. 265 - 271
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0