Terahertz Science and Technology in Astronomy, Telecommunication, and Biophysics DOI Creative Commons
Jing Li, Xianjin Deng,

Yangmei Li

et al.

Research, Journal Year: 2024, Volume and Issue: 8

Published: Dec. 27, 2024

This paper reviews recent developments and key advances in terahertz (THz) science, technology, applications, focusing on 3 core areas: astronomy, telecommunications, biophysics. In THz it highlights major discoveries ongoing projects, emphasizing the role of advanced superconducting technologies, including superconductor–insulator–superconductor (SIS) mixers, hot electron boundedness spectroscopy (HEB), transition-edge sensors (TESs), kinetic inductance detectors (KIDs), while exploring prospects field. For telecommunication, discusses progress solid-state sources, new communication technologies operating within band, diverse modulation methods that enhance transmission capabilities. biophysics, focus shifts to physical waves their impact across biological systems, from whole organisms cellular molecular levels, nonthermal effects fundamental mechanisms. review concludes with an analysis challenges perspectives shaping future technology.

Language: Английский

THz Waves Improve Spatial Working Memory by Increasing the Activity of Glutamatergic Neurons in Mice DOI Creative Commons

Lequan Song,

Zhiwei He, Ji Dong

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(5), P. 370 - 370

Published: March 3, 2025

Terahertz (THz) waves, a novel type of radiation with quantum and electronic properties, have attracted increasing attention for their effects on the nervous system. Spatial working memory, critical component higher cognitive function, is coordinated by brain regions such as infralimbic cortex (IL) region medial prefrontal ventral cornu ammonis 1 (vCA1) hippocampus. However, regulatory THz waves spatial memory underlying mechanisms remain unclear. In this study, 0.152 glutamatergic neuronal activity related were investigated in cell, slice, mouse models. Cellular experiments revealed that exposure 60 min significantly increased intrinsic excitability primary hippocampal neurons, enhanced neuron activity, upregulated expression molecules involved glutamate metabolism. slice experiments, markedly elevated promoted synaptic plasticity, transmission within IL vCA1 regions. Molecular dynamics simulations found could inhibit ion transport function receptors. Moreover, Y-maze tests demonstrated mice exposed to exhibited improved memory. Multiomics analyses indicated induce changes chromatin accessibility increase proportion excitatory neurons. These findings suggested potentially through modifications proportions.

Language: Английский

Citations

0
Terahertz waves promote Ca2+ transport in the Cav2.1 channel DOI
Yuankun Sun, Yangmei Li, Yaxiong Yang

et al.

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2025, Volume and Issue: unknown, P. 126039 - 126039

Published: March 1, 2025

Language: Английский

Citations

0
Terahertz photons promote neuron growth and synapse formation through cAMP signaling pathway DOI Creative Commons
Yuan Zhong, Yun Yu,

Yangmei Li

et al.

PhotoniX, Journal Year: 2025, Volume and Issue: 6(1)

Published: April 1, 2025

Abstract Neurite outgrowth and synapse formation constitute the cellular basis for establishment plasticity of neural networks, crucially involved in cognitive functions. However, techniques currently available to effectively specifically modulate these processes remain limited. In this work, we propose a non-drug non-thermal terahertz (THz) photon modulation approach that enhances neuronal growth synaptogenesis. Frequency screening experiments show 34.5 THz stimulation could promote neurite elongation postsynaptic density protein 95 (PSD95) expression by 26.0% rat hippocampal neurons. Subsequent reveal an upregulation cyclic adenosine monophosphate (cAMP) signaling pathway adenylyl cyclase type 1 (AC1) activity after irradiation. Molecular dynamics simulations suggest photons binding between AC1 ligand, accelerating cAMP generation. vivo further confirm increase levels dendritic spine stimulation, accompanied significant improvement performance. Overall, our results as effective specific method neuromodulation, promising future applications treatment dysfunction.

Language: Английский

Citations

0
Impact of a Terahertz electromagnetic field on the ion permeation of potassium and sodium channels DOI Creative Commons

Zigang Song,

Lingfeng Xue, Qi Ouyang

et al.

Communications Chemistry, Journal Year: 2025, Volume and Issue: 8(1)

Published: April 3, 2025

Ion channels are essential for various physiological processes, and their defects associated with many diseases. Previous research has revealed that a Terahertz electromagnetic field can alter the channel conductance by affecting motion of chemical groups ion channels, hence regulate electric signals neurons. In this study, we conducted molecular dynamics simulations to systematically investigate effects terahertz fields on permeation voltage-gated potassium sodium particularly focusing bound ions in selectivity filters have not been extensively studied previously. Our results identified multiple new characteristic frequencies showed 1.4, 2.2, or 2.9 THz increases permeability Kv1.2, 2.5 48.6 Nav1.5. Such specific directions field, which determined intrinsic oscillation motions permeating filter certain channels. The amplitude positively correlates change permeation. This study demonstrates specifically conductances mechanisms, may carry great potential biomedical applications.

Language: Английский

Citations

0
Terahertz wave induces the structural and functional changes in voltage-gated calcium channel Cav1.1: A molecular dynamics study DOI
Xinrui Jin, Hongguang Wang, Xiaofei Zhao

et al.

The Journal of Chemical Physics, Journal Year: 2025, Volume and Issue: 162(16)

Published: April 25, 2025

Terahertz waves, owing to the special feature of inducing resonance with numerous biomolecules, thus affecting biological activities, have become a novel and promising technology. Recently, effect terahertz waves on neuroscience via ion channel proteins cell membrane has received more attention. A model voltage-gated calcium Cav1.1 embedded was constructed. The vibrational spectra TIP3P molecules carboxyl carbonyl groups in selectivity filter region (13.4, 48.7, 53.2 THz) were calculated. change pore radius distribution secondary structures triggered by external electromagnetic fields are measured. umbrella sampling method is carried out assess functional changes potential mean force profiles Ca2+ permeation. results showed that highly frequency specificity, emphasizing importance biomolecules terahertz-related research.

Language: Английский

Citations

0
Terahertz's Silent Revolution in Physics, Engineering, and Life Science: Beyond the Spectrum DOI Creative Commons
Yuankun Sun, Shaomeng Wang,

Yubing Gong

et al.

Fundamental Research, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

Citations

0
Terahertz Science and Technology in Astronomy, Telecommunication, and Biophysics DOI Creative Commons
Jing Li, Xianjin Deng,

Yangmei Li

et al.

Research, Journal Year: 2024, Volume and Issue: 8

Published: Dec. 27, 2024

This paper reviews recent developments and key advances in terahertz (THz) science, technology, applications, focusing on 3 core areas: astronomy, telecommunications, biophysics. In THz it highlights major discoveries ongoing projects, emphasizing the role of advanced superconducting technologies, including superconductor–insulator–superconductor (SIS) mixers, hot electron boundedness spectroscopy (HEB), transition-edge sensors (TESs), kinetic inductance detectors (KIDs), while exploring prospects field. For telecommunication, discusses progress solid-state sources, new communication technologies operating within band, diverse modulation methods that enhance transmission capabilities. biophysics, focus shifts to physical waves their impact across biological systems, from whole organisms cellular molecular levels, nonthermal effects fundamental mechanisms. review concludes with an analysis challenges perspectives shaping future technology.

Language: Английский

Citations

2