Nickel/Photoredox-Catalyzed Asymmetric Three-Component Cross-Coupling To Access Enantioenriched 1,1-Diaryl(heteroaryl)alkanes

Organic Letters, Год журнала: 2024, Номер 26(41), С. 8792 - 8797

Опубликована: Окт. 8, 2024

An enantioselective 1,2-dicarbofunctionalization of vinyl (hetero)arenes with alkyl bromides and aryl through nickel/photoredox catalysis is described. This three-component domino arylation could generate a diverse array enantioenriched 1,1-diaryl(heteroaryl)alkanes good to excellent yields (up 88%) high enantioselectivities 99%

Язык: Английский

Enantioselective Nickel-Catalyzed Electrochemical Reductive Conjugate Alkenylation of α,β-Unsaturated Ketones

Chemical Science, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 20, 2024

We present an asymmetric electrochemical nickel-catalysed reductive conjugate addition of alkenyl bromides/aryl iodides to α,β-unsaturated ketones in undivided cell, which afforded β-alkenylate/arylate high yields with excellent enantioselectivities.

Язык: Английский