ACS Applied Nano Materials, Год журнала: 2025, Номер unknown
Опубликована: Апрель 15, 2025
Язык: Английский
Materials Today Bio, Год журнала: 2025, Номер unknown, С. 101661 - 101661
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Апрель 3, 2025
Various antitumor strategies have emerged to address the escalating need for effective tumor eradication. However, achieving precise and spatiotemporally controlled dynamic therapies remains promising yet challenging. Sonopiezoelectric nanotherapy eliminates cells by generating reactive oxygen species (ROS) through ultrasound stimulation, enabling spatiotemporal control ensuring safety during deep tissue penetration. In this study, a hybrid bioscaffold incorporating few-layer black phosphorus (BP) nitric oxide (NO) donors are rationally designed engineered sonopiezoelectric-gaseous synergistic therapy. This ultrasound-responsive system provides stepwise countermeasure against invasion in bone tissues. Ultrasonic vibration induces mechanical strain BP nanosheets, leading piezoelectric polarization subsequent ROS generation. Moreover, ultrasound-triggered NO burst release from enables gas The effects of sonopiezoelectric therapy ultrasound-excited enhance eradication, effectively inhibiting proliferation metastasis while minimizing off-target cytotoxicity. Additionally, biomineralization capability degradable proangiogenic low-concentration establish as bioactive platform that facilitates regeneration. development 4D multifunctional therapeutic platform, characterized superior efficacy, release, stimulatory on regeneration, offers new insights into comprehensive treatment invasive tumors.
Язык: Английский
Процитировано
0
ACS Applied Nano Materials, Год журнала: 2025, Номер unknown
Опубликована: Апрель 15, 2025
Язык: Английский
Процитировано
0