Ultrasound-responsive nanoparticles for imaging and therapy of brain tumors

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101661 - 101661

Published: March 1, 2025

Language: Английский

Ultrasound‐Responsive 4D Bioscaffold for Synergistic Sonopiezoelectric‐Gaseous Osteosarcoma Therapy and Enhanced Bone Regeneration

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

Various antitumor strategies have emerged to address the escalating need for effective tumor eradication. However, achieving precise and spatiotemporally controlled dynamic therapies remains promising yet challenging. Sonopiezoelectric nanotherapy eliminates cells by generating reactive oxygen species (ROS) through ultrasound stimulation, enabling spatiotemporal control ensuring safety during deep tissue penetration. In this study, a hybrid bioscaffold incorporating few-layer black phosphorus (BP) nitric oxide (NO) donors are rationally designed engineered sonopiezoelectric-gaseous synergistic therapy. This ultrasound-responsive system provides stepwise countermeasure against invasion in bone tissues. Ultrasonic vibration induces mechanical strain BP nanosheets, leading piezoelectric polarization subsequent ROS generation. Moreover, ultrasound-triggered NO burst release from enables gas The effects of sonopiezoelectric therapy ultrasound-excited enhance eradication, effectively inhibiting proliferation metastasis while minimizing off-target cytotoxicity. Additionally, biomineralization capability degradable proangiogenic low-concentration establish as bioactive platform that facilitates regeneration. development 4D multifunctional therapeutic platform, characterized superior efficacy, release, stimulatory on regeneration, offers new insights into comprehensive treatment invasive tumors.

Language: Английский

Pt–PtTe₂ Nanoparticles with Heterojunction-Based Accelerated Electron Transfer for Efficient Tumor Therapy

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 15, 2025

Language: Английский