Biosensors and Bioelectronics, Год журнала: 2024, Номер 266, С. 116722 - 116722
Опубликована: Авг. 29, 2024
Язык: Английский
Science China Chemistry, Год журнала: 2024, Номер unknown
Опубликована: Дек. 5, 2024
Язык: Английский
Процитировано
10
Nano-Micro Letters, Год журнала: 2025, Номер 17(1)
Опубликована: Март 10, 2025
Abstract The treatment of ammonia nitrogen wastewater (ANW) has garnered significant attention due to the ecology, and even biology is under increasing threat from over discharge ANW. Conventional ANW methods often encounter challenges such as complex processes, high costs secondary pollution. Considerable progress been made in employing solar-induced evaporators for treatment. However, there remain notable barriers transitioning fundamental research practical applications, including insufficient evaporation rates inadequate resistance biofouling. Herein, we propose a novel evaporator, which comprises bio-enzyme-treated wood aerogel that serves water pumping storage layer, cost-effective multi-walled carbon nanotubes coated hydrophobic/hydrophilic fibrous nonwoven mat functioning photothermal aggregation-induced emission (AIE) molecules incorporated anti-biofouling agent. resultant bioinspired evaporator demonstrates rate 12.83 kg m −2 h −1 when treating simulated containing 30 wt% NH 4 Cl 1.0 sun illumination. AIE-doped exhibits remarkable photodynamic antibacterial activity against mildew bacteria, ensuring outstanding biofouling extended periods When enhanced by natural wind irradiation, achieves an impressive exceeding 20 . This advancement represents promising viable approach effective removal wastewater.
Язык: Английский
Процитировано
0
Biomaterials, Год журнала: 2025, Номер unknown, С. 123340 - 123340
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
TrAC Trends in Analytical Chemistry, Год журнала: 2024, Номер 180, С. 117886 - 117886
Опубликована: Июль 22, 2024
Язык: Английский
Процитировано
4
Aggregate, Год журнала: 2025, Номер unknown
Опубликована: Янв. 20, 2025
ABSTRACT Human papillomavirus (HPV) is a highly prevalent venereal pathogen accounting for genital warts and various cancers like cervical, anal, oropharyngeal cancers. Although imiquimod, topical medication, commonly used to treat induced by HPV, its potential as an in situ immune response regulator HPV‐related has rarely been explored. In this study, we developed innovative synergistic therapeutic platform integrating near‐infrared‐II (NIR‐II) absorbing aggregation‐induced emission (AIE) agent (TPE‐BT‐BBTD) imiquimod into injectable hydrogel named TIH. TPE‐BT‐BBTD molecule that serves photothermal agent, with exposure 1064 nm laser, effectively destroys tumor cells releases tumor‐related antigens. During the thermogenesis process, melts imiquimod. The released conjunction dead antigens, stimulates dendritic cell maturation, activating system ultimately eliminate residual cancer cells. This novel approach combines immunomodulatory effects of nm‐excitable delivery system, offering promising tactic combating HPV‐associated
Язык: Английский
Процитировано
0
Biomaterials, Год журнала: 2025, Номер unknown, С. 123126 - 123126
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Chemical & Biomedical Imaging, Год журнала: 2025, Номер unknown
Опубликована: Фев. 14, 2025
Язык: Английский
Процитировано
0
Chem, Год журнала: 2025, Номер unknown, С. 102534 - 102534
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Aggregate, Год журнала: 2024, Номер unknown
Опубликована: Авг. 2, 2024
Abstract Photodynamic therapy is a highly recommended alternative treatment for solid tumors, such as cutaneous or luminal in clinical practice. However, conventional photosensitizers (PSs) often induce undesirable phototoxic effects because of their normal tissue distribution and reduction antitumor resulting from aggregation‐caused quenching effects. The present study developed novel nano‐formulated aggregation‐induced emission (AIE)‐characteristic PS, nab‐TTVPHE, which composed human serum albumin carrier TTVPHE therapeutic agent, more effective cancer with lower Notably, the reactive oxygen species generated by were shielded nanoaggregate structure, photodynamic activity was after nanostructure dissociation. Nab‐TTVPHE actively internalized tumor cells via secreted protein, acidic rich cysteine released to form nanoaggregates. accumulated mitochondria, where it triggered mitochondrial damage under light irradiation its induced pyroptosis caspase‐3/gasdermin E (GSDME) signaling pathway kill cells. Therefore, this AIE‐characteristic PS provides an innovative strategy effect ability boost potential immunity GSDME‐mediated pyroptosis.
Язык: Английский
Процитировано
2
ACS Nano, Год журнала: 2024, Номер unknown
Опубликована: Дек. 3, 2024
Cuproptosis is a type of metabolic cell death and exhibits great potential for cancer treatment. However, currently, most cuproptosis-based therapies are primarily effective in tumor cells reliant on mitochondrial respiration, limiting their broader application. The Warburg effect highlights that many tumors predominantly rely glycolysis to meet rapid demands, but glycolysis-dependent less sensitive copper ions than mitochondrial-respiration-dependent counterparts, making it difficult induce cuproptosis these cells. Herein, we designed copper-loaded peptide-based nanoparticle (MHRC@Cu) enhance by reprogramming wider range Specifically, triggered the acidic environment laser irradiation, MHRC@Cu effectively released Cu2+ inside Then peptide-conjugated probe (MHRC) reprogrammed cells, them more dependent respiration increasing sensitivity ions. Additionally, H2O2 generated photodynamic underwent Fenton reaction with situ, producing highly toxic ·OH, which depleted GSH disrupted efflux protein, thereby exacerbating deposition Through synergistic mechanisms, significantly enhanced achieving up 96% inhibition growth. This offers versatile potent strategy enhancing may inspire development advanced self-assembled nanotherapeutic platforms.
Язык: Английский
Процитировано
2