Leveraging Tumor Microenvironment to Boost Synergistic Photodynamic Therapy, Ferroptosis Anti‐Tumor Efficiency Based on a Functional Iridium(III) Complex

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Фев. 14, 2025

Abstract The tumor microenvironment (TME) severely limits the efficacy of clinical applications photodynamic therapy (PDT). development a functional agent allowing full use TME to boost synergistic PDT and ferroptosis anti‐tumor efficiency is an appealing yet significantly challenging task. Herein, overcome adverse influence on hypoxia high level glutathione (GSH) in TME, imine bond introduced into Ir(III)‐ferrocene complex construct small molecule drug, named Ir‐Fc, for tumors’ imaging therapy. cleavage lysosome effectively disrupts photoinduced electron transfer (PET) process, realizing decomposition Ir‐Fc Fc‐CHO Ir‐NH 2 . produces •OH by Fenton reactions under dark conditions induces cells, shows prominent performance type‐I type‐II reactive oxygen species (ROS) production. Meanwhile, pathway simultaneously consumes large amounts GSH O relieving hypoxia. These distinctive outputs make exceptional effective This study thus brings new revolutionary protocol practical cancer treatment.

Язык: Английский

Oxygen self-supplying perfluorocarbon-functionalized ferrocene nanosheets for enhanced cancer chemodynamic therapy

Materials Today Chemistry, Год журнала: 2025, Номер 45, С. 102681 - 102681

Опубликована: Апрель 1, 2025

Язык: Английский