Materials Today Chemistry, Journal Year: 2025, Volume and Issue: 45, P. 102681 - 102681
Published: April 1, 2025
Language: Английский
Materials Today Chemistry, Journal Year: 2025, Volume and Issue: 45, P. 102681 - 102681
Published: April 1, 2025
Language: Английский
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 14, 2025
Abstract The tumor microenvironment (TME) severely limits the efficacy of clinical applications photodynamic therapy (PDT). development a functional agent allowing full use TME to boost synergistic PDT and ferroptosis anti‐tumor efficiency is an appealing yet significantly challenging task. Herein, overcome adverse influence on hypoxia high level glutathione (GSH) in TME, imine bond introduced into Ir(III)‐ferrocene complex construct small molecule drug, named Ir‐Fc, for tumors’ imaging therapy. cleavage lysosome effectively disrupts photoinduced electron transfer (PET) process, realizing decomposition Ir‐Fc Fc‐CHO Ir‐NH 2 . produces •OH by Fenton reactions under dark conditions induces cells, shows prominent performance type‐I type‐II reactive oxygen species (ROS) production. Meanwhile, pathway simultaneously consumes large amounts GSH O relieving hypoxia. These distinctive outputs make exceptional effective This study thus brings new revolutionary protocol practical cancer treatment.
Language: Английский
Citations
0Materials Today Chemistry, Journal Year: 2025, Volume and Issue: 45, P. 102681 - 102681
Published: April 1, 2025
Language: Английский
Citations
0