Molecular Motion and Nonradiative Decay: Towards Efficient Photothermal and Photoacoustic Systems

Angewandte Chemie International Edition, Год журнала: 2022, Номер 61(30)

Опубликована: Май 11, 2022

Nonradiative decay invariably competes with radiative during the deexcitation process of matter. In community luminescence research, nonradiative has been deemed less attractive than decay. However, all things in their being are good for something and so is As molecular motion-facilitated (MMFND) effect inevitable photophysical processes, it provides a new avenue to convert harvested light energy into exploitable forms by harnessing motion. many cases, active motion enables thermal deactivation from excited states. this Minireview, recent advances photothermal photoacoustic systems MMFND character summarized. We believe that presentation rational engineering efficient generation will deepen understanding relationship between navigate people rethink positive aspects establishment light-controllable techniques.

Язык: Английский

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A Sensitive and Reliable Organic Fluorescent Nanothermometer for Noninvasive Temperature Sensing

Journal of the American Chemical Society, Год журнала: 2021, Номер 143(35), С. 14147 - 14157

Опубликована: Июль 21, 2021

Sensing temperature at the subcellular level is of great importance for understanding miscellaneous biological processes. However, development sensitive and reliable organic fluorescent nanothermometers remains challenging. In this study, we report fabrication a novel nanothermometer study its application in sensing. First all, synthesize dual-responsive luminogen that can respond to molecular state aggregation environmental polarity. Next, natural saturated fatty acids with sharp melting points as well reversible rapid phase transition are employed encapsulation matrix correlate external heat information fluorescence properties luminogen. To apply composite materials application, formulate them into colloidally dispersed nanoparticles by technique combines situ surface polymerization nanoprecipitation. As anticipated, resultant zwitterionic exhibits sensitive, reversible, reliable, multiparametric responses variation within narrow range around physiological (i.e., 37 °C). Taking spectral position, intensity, lifetime correlation parameters, maximum relative thermal sensitivities determined be 2.15% °C–1, 17.06% 17.72% respectively, which much higher than most nanothermometers. Furthermore, achieve multimodal sensing bacterial biofilms using these three complementary parameters. Besides, also fabricate cationic form facilitate efficient cellular uptake, holding promise studying behaviors systems.

Язык: Английский

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A Feasible Strategy of Fabricating Type I Photosensitizer for Photodynamic Therapy in Cancer Cells and Pathogens

ACS Nano, Год журнала: 2021, Номер 15(4), С. 7735 - 7743

Опубликована: Апрель 15, 2021

The utilization of photochemical reaction channel based on radical process is rarely reported, which might be a very efficient and feasible strategy for improving generation Type I reactive oxygen species (ROS). In this work, double ionic-type aggregation-induced emission luminogen (AIEgen) TIdBO was developed as photosensitizer, the potential photocyclization characteristic involving an electron-transfer had positive effect ROS in aggregates under continuous light irradiation. Its noticeable photodynamic therapy (PDT) performance self-monitoring PDT by relationship between cellular morphology change fluorescence intensity enhancement were achieved. addition, it showed good killing ability to microbes specific interactions with but not cells regulating incubation time. These intriguing results reveal design principle implementation PS preparation clinical treatment hypoxic conditions.

Язык: Английский

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Biomedical polymers: synthesis, properties, and applications

Science China Chemistry, Год журнала: 2022, Номер 65(6), С. 1010 - 1075

Опубликована: Апрель 24, 2022

Язык: Английский

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Type I AIE photosensitizers: Mechanism and application

View, Год журнала: 2021, Номер 3(2)

Опубликована: Июль 13, 2021

Abstract Photodynamic therapy (PDT) with plenty of advantages is expected to become a promising modality for cancer treatment, but challenges still remain. In the past decade, abundant photosensitizers (PSs) aggregation‐induced emission (AIE) property make development PSs enter upon new phase, offering incomparable merits. Recently, Type I AIE capability generating radical reactive oxygen species (ROS) have emerged as strong candidates overcome inherent hypoxia nature solid tumors. this review, detailed discussions on mechanisms PDT are drawn highlight basic pathway over II one in hypoxic PDT, followed by summary frequently‐used detection methods accurate distinguishing ROS. Finally, latest representative advances summarized, and future perspectives discussed.

Язык: Английский

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Amplification of Activated Near-Infrared Afterglow Luminescence by Introducing Twisted Molecular Geometry for Understanding Neutrophil-Involved Diseases

Journal of the American Chemical Society, Год журнала: 2022, Номер 144(8), С. 3429 - 3441

Опубликована: Янв. 20, 2022

Understanding the mechanism and progression of neutrophil-involved diseases (e.g., acute inflammation) is great importance. However, current available analytical methods neither achieve real-time monitoring nor provide dynamic information during pathological processes. Herein, a peroxynitrite (ONOO–) environmental pH dual-responsive afterglow luminescent nanoprobe designed synthesized. In presence ONOO– at physiological pH, nanoprobes show activated near-infrared luminescence, whose intensity lasting time can be highly enhanced by introducing aggregation-induced emission (AIE) effect with twisted molecular geometry into system. vivo studies using three diseased animal models demonstrate that sensitively reveal development process skin inflammation including infiltration first arrived neutrophils acidification initiating time, make fast accurate discrimination between allergy inflammation, rapidly screen antitumor drugs capable inducing immunogenic cell death. This work provides an alternative approach advanced probes permitting precise disease in real time.

Язык: Английский

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New Phenothiazine Derivatives That Exhibit Photoinduced Room‐Temperature Phosphorescence

Advanced Functional Materials, Год журнала: 2021, Номер 31(40)

Опубликована: Июль 11, 2021

Abstract The research of purely organic room‐temperature phosphorescence (RTP) materials with stimulus response characteristic has drawn increasing attention for their broad application prospects. However, these kinds are really scarce now, especially those efficient RTP emissions, which have largely limited practical applications. Here, an all‐around‐type player in the field photoinduced material appears, whose efficiency can increase from near 0 to 22% after continuous UV irradiation. Correspondingly, UV‐written patterns based on them be clearly observed by naked eye daytime or even under sunlight. Moreover, found show excellent photostability, and strong emission still repeated activation more than 50 times. high good photostability make exhibit attractive prospect potential applications many fields, including leak test, microcrack detection, programmable information storage, encryption.

Язык: Английский

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Triple‐Jump Photodynamic Theranostics: MnO₂ Combined Upconversion Nanoplatforms Involving a Type‐I Photosensitizer with Aggregation‐Induced Emission Characteristics for Potent Cancer Treatment

Advanced Materials, Год журнала: 2021, Номер 33(41)

Опубликована: Авг. 22, 2021

The development of multifunctional nanoplatforms has been recognized as a promising strategy for potent photodynamic theranostics. Aggregation-induced emission (AIE) photosensitizers undergoing Type-I reactive oxygen species (ROS) generation pathway appear potential candidates due to their capability hypoxia-tolerance, efficient ROS production, and fluorescence imaging navigation. To further improve performance, facile universal method constructing type glutathione (GSH)-depleting near-infrared (NIR)-regulated nanoplatform dual-modal imaging-guided therapy (PDT) is presented. are obtained through the coprecipitation process involving upconversion nanoparticles (UCNPs) AIE-active photosensitizers, followed by in situ MnO2 outer shell. introduction UCNPs actualizes NIR-activation produce ·OH ROS. Intracellular upregulated GSH-responsive decomposition shell Mn2+ realizes GSH-depletion, which distinctive approach elevating intracellular ·OH. Meanwhile, generated can implement T1 -weighted magnetic resonance (MRI) specific tumor sites, mediate conversion H2 O2 These outputs reveal triple-jump this brings about distinguished performance FLI-MRI-guided PDT with high-efficacy, presents great future clinical translations.

Язык: Английский

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Self-Assembled Metallacage with Second Near-Infrared Aggregation-Induced Emission for Enhanced Multimodal Theranostics

Journal of the American Chemical Society, Год журнала: 2022, Номер 144(28), С. 12825 - 12833

Опубликована: Июль 5, 2022

The construction of supramolecular coordination complexes (SCCs) featuring prominent cancer theranostic functions is an appealing yet significantly challenging task. In this study, we rationally designed and facilely constructed a prism-like metallacage C-DTTP with efficient fluorescence emission in the second near-infrared (NIR-II) region through assembly aggregation-induced emission-active four-arm ligand 90° Pt acceptors Pt(PEt3)2(OTf)2. held longest maximum wavelength (1005 nm) compared those previously reported SCCs up to now exhibited both high photothermal conversion efficiency (39.3%) superior reactive oxygen species generation behavior precursor ligand. vitro vivo assessments demonstrated that metallacage-loaded nanoparticles excellent biocompatibility stability were capable simultaneously affording precise tumor diagnosis complete elimination by means NIR-II fluorescence/photothermal dual imaging-guided photodynamic/photothermal synergistic therapy.

Язык: Английский

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AIE-active luminogens as highly efficient free-radical ROS photogenerator for image-guided photodynamic therapy

Chemical Science, Год журнала: 2022, Номер 13(12), С. 3599 - 3608

Опубликована: Янв. 1, 2022

Image-guided photodynamic therapy (PDT) can realize highly precise and effective via the integration of imaging therapy, has created high requirements for photosensitizers. However, PDT modality usually utilizes conventional type II photosensitizers, resulting in unsatisfactory therapeutic outcomes due to aggregation-caused quenching (ACQ), "always on" fluorescence strong oxygen dependence. Herein, we report I-based aggregation-induced emission (AIE) photosensitizer TCM-CPS with low dependence, near-infrared (NIR) "off-on" fluorescence; particular, it produces more reactive species (ROS) than commercially available Chlorin e6 Rose Bengal. In rational design AIE-based TCM-CPS, strongly electron-donating carbazole unit π-thiophene bridge distinctly extend wavelength decrease autofluorescence interference bio-imaging, hydrophilic pyridinium salt group guarantees good molecular dispersion maintains fluorescence-off state aqueous system initial background. Moreover, donor-π-acceptor (D-π-A) character greatly separates HOMO-LUMO distribution, enhancing ROS generation, was constructed as a I assistance intramolecular charge transfer electron-rich anion-π+ structure. Based on its favorable hydrophilicity photosensitivity, found be efficient free-radical photogenerator both visualizing cells using light-up NIR efficiently killing cancer upon light irradiation. The positively charged could quickly bind bacteria electrostatic interactions provide signal kill at concentration. treatment bacteria-infected mice, mice exhibited accelerated wound healing infection. Thus, great potential replace photosensitizers image-guided bacterial

Язык: Английский

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