Aggregation-Induced Emission (AIE), Life and Health

ACS Nano, Год журнала: 2023, Номер 17(15), С. 14347 - 14405

Опубликована: Июль 24, 2023

Light has profoundly impacted modern medicine and healthcare, with numerous luminescent agents imaging techniques currently being used to assess health treat diseases. As an emerging concept in luminescence, aggregation-induced emission (AIE) shown great potential biological applications due its advantages terms of brightness, biocompatibility, photostability, positive correlation concentration. This review provides a comprehensive summary AIE luminogens applied structure dynamic physiological processes, disease diagnosis treatment, detection monitoring specific analytes, followed by representative works. Discussions on critical issues perspectives future directions are also included. aims stimulate the interest researchers from different fields, including chemistry, biology, materials science, medicine, etc., thus promoting development fields life health.

Язык: Английский

---

Anti‐Quenching NIR‐II J‐Aggregates of Benzo[c]thiophene Fluorophore for Highly Efficient Bioimaging and Phototheranostics

Advanced Materials, Год журнала: 2023, Номер 35(20)

Опубликована: Март 3, 2023

Molecular fluorophores with the second near-infrared (NIR-II) emission hold great potential for deep-tissue bioimaging owing to their excellent biocompatibility and high resolution. Recently, J-aggregates are used construct long-wavelength NIR-II emitters as optical bands show remarkable red shifts upon forming water-dispersible nano-aggregates. However, wide applications in fluorescence imaging impeded by limited varieties of J-type backbone serious quenching. Herein, a bright benzo[c]thiophene (BT) J-aggregate fluorophore (BT6) anti-quenching effect is reported highly efficient phototheranostics. The BT manipulated have Stokes shift over 400 nm aggregation-induced (AIE) property conquering self-quenching issue fluorophores. Upon BT6 assemblies an aqueous environment, absorption 800 1000 boosted more than 41 26 folds, respectively. In vivo visualization whole-body blood vessel imaging-guided phototherapy results verify that NPs agent cancer This work develops strategy precisely properties biomedical applications.

Язык: Английский

---

De Novo Design of Reversibly pH-Switchable NIR-II Aggregation-Induced Emission Luminogens for Efficient Phototheranostics of Patient-Derived Tumor Xenografts

Journal of the American Chemical Society, Год журнала: 2022, Номер 145(1), С. 334 - 344

Опубликована: Дек. 27, 2022

Phototheranostics has received sustained attention due to its great potential in revolutionizing conventional strategies of cancer treatment. However, trapped by the complexity, poor reproducibility, insufficient phototheranostic outputs, and inevitable damage normal tissue most multicomponent systems, clinical translation been severely hindered. Therefore, exploration "one for all" smart agents with versatile functionalities remains an appealing yet enormously challenging task. Herein, a reversibly pH-switchable near-infrared second photosensitizer featuring aggregation-induced emission was tactfully designed molecular engineering precise tumor-targeting fluorescence imaging-guided phototherapy. Thanks strong intramolecular charge transfer, enhanced highly efficient intersystem crossing, sufficient motion, developed agent DTTVBI endowed boosted type-I superoxide anion radical generation excellent photothermal performance under 808 nm laser irradiation. More importantly, nanoparticles high biocompatibility exhibit remarkably photodynamic/photothermal therapy tumor region, thus offering significant antitumor effects both vitro patient-derived xenograft model colon cancer. This work sheds new light on development superior phototheranostics therapy.

Язык: Английский

---

Near-infrared metal agents assisting precision medicine: from strategic design to bioimaging and therapeutic applications

Chemical Society Reviews, Год журнала: 2023, Номер 52(13), С. 4392 - 4442

Опубликована: Янв. 1, 2023

Metal agents have made incredible strides in preclinical research and clinical applications, but their short emission/absorption wavelengths continue to be a barrier distribution, therapeutic action, visual tracking, efficacy evaluation.

Язык: Английский

---

Aggregation‐induced emission luminogens for in vivo molecular imaging and theranostics in cancer

Aggregate, Год журнала: 2023, Номер 4(5)

Опубликована: Май 6, 2023

Abstract Cancer is one of the most fatal diseases for decades. Aggregation‐induced emission luminogens (AIEgens) have been recently used as molecular imaging or therapeutic agents in cancers, due to advantages large Stokes shift, high quantum yield, great biocompatibility, and strong photostability. AIEgens can specifically target different types cancer via diverse targeting strategies. AIEgen‐based fluorescence imaging, especially near‐infrared demonstrated deep penetration suitable signal‐to‐noise ratio, which allows reliable vivo imaging. Combined with other modalities, multimodal could provide multidimensional hallmarks from perspectives. In addition, phototherapy be photodynamic therapy photothermal therapy, facilitate ablation cells good biosafety effects vivo. nanoparticles fabricated some specific chemicals, drugs, siRNA, display synergistic cancers. This paper comprehensively describes current status future perspectives AIEgens, showed a potential preclinical clinical translation on theranostics cancer.

Язык: Английский

---

“Trojan Horse” Phototheranostics: Fine‐Engineering NIR‐II AIEgen Camouflaged by Cancer Cell Membrane for Homologous‐Targeting Multimodal Imaging‐Guided Phototherapy

Advanced Materials, Год журнала: 2023, Номер 35(33)

Опубликована: Май 11, 2023

Multimodal phototheranostics on the basis of a single molecule with one-for-all characteristics represents convenient approach for effective cancer treatment. In this report, versatile featured by aggregation-induced emission, namely DHTDP, synchronously enabling second near-infrared (NIR-II) fluorescence emission and efficient photothermal conversion is developed elaborate structural modulation. By camouflaging DHTDP nanoparticles cell membrane, resultant biomimetic exhibit significantly both facilitated delivery efficiency homologous targeting capability, afford precise imaging guidance maximize therapeutic outcomes in form NIR-II (FLI)-photoacoustic (PAI)-photothermal (PTI) trimodal imaging-guided therapy (PTT). This study presents first example multimodal loaded homogeneity-targeting thus brings new insight into exploration superior practical theranostics.

Язык: Английский

---

Engineered Metallacycle‐Based Supramolecular Photosensitizers for Effective Photodynamic Therapy

Angewandte Chemie International Edition, Год журнала: 2023, Номер 62(15)

Опубликована: Фев. 14, 2023

Abstract Although metallacycle‐based supramolecular photosensitizers (PSs) have attracted increasing attention in biomedicine, their clinical translation is still hindered by inherent dark toxicity. Herein, we report what to our knowledge the first example of a molecular engineering approach building blocks metallacycles for constructing series PSs ( RuA–RuD ), with aim simultaneously reducing toxicity and enhancing phototoxicity, consequently obtaining high phototoxicity indexes (PI). Detailed vitro investigations demonstrate that display cancer cellular uptake remarkable antitumor activity even under hypoxic conditions. Notably, RuD exhibited no displayed highest PI value (≈406). Theoretical calculations verified has largest steric hindrance lowest singlet‐triplet energy gap (Δ E ST , 0.61 eV). Further vivo studies confirmed allows safe effective phototherapy against A549 tumors.

Язык: Английский

---

Synchronously Manipulating Absorption and Extinction Coefficient of Semiconducting Polymers via Precise Dual‐Acceptor Engineering for NIR‐II Excited Photothermal Theranostics

Angewandte Chemie International Edition, Год журнала: 2023, Номер 62(20)

Опубликована: Март 17, 2023

Integrating the ultralong excitation wavelength, high extinction coefficient, and prominent photothermal conversion ability into a single agent is an appealing yet significantly challenging task. Herein, precise dual-acceptor engineering strategy exploited for this attempt based on donor-acceptor (D-A) type semiconductor polymers by subtly regulating molar proportions of two employed electron acceptor moieties featuring different electronic affinity π-conjugation degrees, making full use active intramolecular motion-induced effect. The optimal polymer SP4 synchronously shows desirable second near-infrared (NIR-II) absorption, extremely satisfactory behavior. Consequently, unprecedented performance NPs 1064 nm laser-excited photoacoustic imaging (PAI)-guided therapy (PTT) demonstrated tumor diagnosis complete elimination.

Язык: Английский

---

More Is Better: Dual-Acceptor Engineering for Constructing Second Near-Infrared Aggregation-Induced Emission Luminogens to Boost Multimodal Phototheranostics

Journal of the American Chemical Society, Год журнала: 2023, Номер 145(41), С. 22776 - 22787

Опубликована: Окт. 9, 2023

The manipulation of electron donor/acceptor (D/A) shows an endless impetus for innovating optical materials. Currently, there is booming development in donor design, while research on acceptor engineering has received limited attention. Inspired by the philosophical idea "more different", two systems with D'-D-A-D-D' (1A system) and D'-D-A-A-D-D' (2A structures based were designed studied. It was demonstrated that 1A system presented a weak aggregation-induced emission (AIE) to aggregation-caused quenching (ACQ) phenomenon, along increased electrophilicity planarity. In sharp contrast, 2A one more exhibited opposite ACQ-to-AIE transformation. Interestingly, fluorophore electron-deficient A-A moiety displayed superior AIE activity. More importantly, all compounds showed significantly higher molar absorptivity (ε) comparison their counterparts system. Thanks highest ε, near-infrared-II (NIR-II, 1000-1700 nm) emission, desirable property, favorable reactive oxygen species (ROS) generation, high photothermal conversion efficiency, representative member handily performed fluorescence-photoacoustic-photothermal multimodal imaging-guided photodynamic-photothermal collaborative therapy efficient tumor elimination. Meanwhile, NIR-II fluorescence imaging blood vessels lymph nodes living mice also accomplished. This study provides first evidence dual-connected tactic could be new molecular design direction effect, resulting aggregation-intensified improved ROS heat generation capacities phototheranostic agents.

Язык: Английский

---

Adding Flying Wings: Butterfly-Shaped NIR-II AIEgens with Multiple Molecular Rotors for Photothermal Combating of Bacterial Biofilms

Journal of the American Chemical Society, Год журнала: 2023, Номер 145(47), С. 25705 - 25715

Опубликована: Ноя. 16, 2023

The ever-increasing threats of multidrug-resistant bacteria and their biofilm-associated infections have bred a desperate demand for alternative remedies to combat them. Near-infrared (NIR)-absorbing photothermal agent (PTAs)-mediated therapy (PTT) is particularly attractive biofilm ablation thanks its superiorities noninvasive intervention, satisfactory antibacterial efficiency, less likelihood develop resistance. Herein, three butterfly-shaped aggregation-induced emission luminogens (AIEgens) with balanced nonradiative decay (for conducting PTT) radiative supplying fluorescence in the NIR-II optical window) are rationally designed imaging-assisted obliteration bacterial biofilms. After being encapsulated into cationic liposomes, AIEgens-fabricated nanoparticles can eradicate wide spectrum biofilms formed by Gram-positive (methicillin-resistant Staphylococcus aureus Enterococcus faecalis) Gram-negative (Escherichia coli Pseudomonas aeruginosa) upon an 808 nm laser irradiation. In vivo experiments firmly demonstrate that AIE liposomes excellent biocompatibility perform well both P. aeruginosa biofilm-induced keratitis mouse model MSRA skin infection model.

Язык: Английский

---