Stimuli‐Responsive Hydrogels for Antibacterial Applications

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(22)

Опубликована: Май 9, 2024

Hydrogels have emerged as promising candidates for biomedical applications, especially in the field of antibacterial therapeutics, due to their unique structural properties, highly tunable physicochemical and excellent biocompatibility. The integration stimuli-responsive functions into hydrogels holds potential enhance properties therapeutic efficacy, dynamically responding different external or internal stimuli, such pH, temperature, enzymes, light. Therefore, this review describes applications hydrogel dressings responsive stimuli therapy. collaborative interaction between materials is discussed. This synergistic approach, contrast conventional materials, not only amplifies effect but also alleviates adverse side effects diminishes incidence multiple infections drug resistance. provides a comprehensive overview current challenges outlines future research directions hydrogels. It underscores imperative ongoing interdisciplinary aimed at unraveling mechanisms wound healing. understanding crucial optimizing design implementation Ultimately, aims offer scientific guidance development practical clinical application dressings.

Язык: Английский

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Focused ultrasound enables selective actuation and Newton-level force output of untethered soft robots

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Июнь 18, 2024

Abstract Untethered miniature soft robots have significant application potentials in biomedical and industrial fields due to their space accessibility safe human interaction. However, the lack of selective forceful actuation is still challenging revolutionizing unleashing versatility. Here, we propose a focused ultrasound-controlled phase transition strategy for achieving millimeter-level spatially Newton-level force robots, which harnesses ultrasound-induced heating trigger inside robot, enabling powerful through inflation. The spatial resolution empowers single robot perform multiple tasks according specific requirements. As concept-of-demonstration, designed liquid cargo delivery biopsy tissue acquisition patching. Additionally, an autonomous control system integrated with ultrasound imaging enable automatic acoustic field alignment control. proposed method advances spatiotemporal response capability untethered holding promise broadening versatility adaptability.

Язык: Английский

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Active Microrobots for Dual Removal of Biofilms via Chemical and Physical Mechanisms

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер 17(2), С. 3608 - 3619

Опубликована: Янв. 2, 2025

Bacterial biofilms are complex multicellular communities that adhere firmly to solid surfaces. They widely recognized as major threats human health, contributing issues such persistent infections on medical implants and severe contamination in drinking water systems. As a potential treatment for biofilms, this work proposes two strategies: (i) light-driven ZnFe2O4 (ZFO)/Pt microrobots photodegradation of (ii) magnetically driven ZFO mechanical removal from Magnetically were realized by synthesizing microspheres through low-cost large-scale hydrothermal synthesis, followed calcination process. Then, Pt layer was deposited the surface break their symmetry, resulting self-propelled Janus ZFO/Pt microrobots. Light-driven exhibited active locomotion under UV light irradiation controllable motion terms "stop go" features. capable maneuvering precisely when subjected an external rotating magnetic field. These could eliminate Gram-negative Escherichia coli (E. coli) photogenerated reactive oxygen species (ROS)-related antibacterial properties combination with light-powered locomotion, accelerating mass transfer remove more effectively water. Moreover, actuation allowed physical disruption which represents reliable alternative photocatalysis strongly anchored confined spaces. With versatile characteristics, envisioned highlight significant biofilm high efficacy both open spaces, pipelines industrial plants.

Язык: Английский

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Endogenous/exogenous stimuli‐responsive smart hydrogels for diabetic wound healing

Aggregate, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 6, 2024

Abstract Diabetes significantly impairs the body's wound‐healing capabilities, leading to chronic, infection‐prone wounds. These wounds are characterized by hyperglycemia, inflammation, hypoxia, variable pH levels, increased matrix metalloproteinase activity, oxidative stress, and bacterial colonization. complex conditions complicate effective wound management, prompting development of advanced diabetic care strategies that exploit specific characteristics such as acidic pH, high glucose stress trigger controlled drug release, thereby enhancing therapeutic effects dressings. Among solutions, hydrogels emerge promising due their stimuli‐responsive nature, making them highly for managing these The latest advancements in mono/multi‐stimuli‐responsive smart showcase superiority potential healthcare materials, highlighted relevant case studies. However, traditional dressings fall short meeting nuanced needs wounds, adjustable adhesion, easy removal, real‐time status monitoring, dynamic release adjustment according wound's conditions. Responsive represent a significant leap forward proficient sensing responding environment, offering more targeted approach treatment. This review highlights recent dressing, delivery, emphasizing role improving healing. It addresses ongoing challenges future directions, aiming guide clinical adoption.

Язык: Английский

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Polysaccharides, proteins and DNA based stimulus responsive hydrogels promoting wound healing and repair: A review

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 304, С. 140961 - 140961

Опубликована: Фев. 12, 2025

Язык: Английский

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Targeting biofilm infections in humans using small scale robotics

Trends in biotechnology, Год журнала: 2023, Номер 42(4), С. 479 - 495

Опубликована: Ноя. 13, 2023

The eradication of drug-resistant microbial biofilms remains an unresolved global health challenge. Small-scale robotics are providing innovative therapeutic and diagnostic approaches with high precision efficacy. These rapidly moving from proof-of-concept studies to translational biomedical applications using ex vivo, animal, clinical models. Here, we discuss the fundamental aspects how microrobots target infection sites disrupt structural functional traits their antimicrobial resistance mechanisms. We emphasize current mechanochemical disruption on-site drug delivery that supported by in vivo models preclinical testing, while also highlighting diagnostics potential. translation challenges provide perspectives for development microrobotics combat biofilm infections biofouling humans.

Язык: Английский

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Liquid-bodied antibiofilm robot with switchable viscoelastic response for biofilm eradication on complex surface topographies

Science Advances, Год журнала: 2025, Номер 11(11)

Опубликована: Март 12, 2025

Recalcitrant biofilm infections pose a great challenge to human health. Micro- and nanorobots have been used eliminate in hard-to-reach regions inside the body. However, applying antibiofilm robots under physiological conditions is limited by conflicting demands of accessibility driving force. Here, we introduce liquid-bodied robot constructed dynamically cross-linked magnetic hydrogel. Leveraging viscoelastic response enables it adapt complex surface topographies such as medical meshes stents. Upon actuation, can mechanically destroy matrix, chemically deactivate bacterial cells, collect disrupted debris. The robot’s performance studied vitro demonstrated on mesh biliary stent. Tracking navigation endoscopy x-ray imaging an ex vivo porcine bile duct are demonstrated. Last, treatment conducted indwelling infected stents into mice’s abdominal cavity clearing infection using proposed robot.

Язык: Английский

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Magnetic Cell-Mimetic Droplet Microrobots with Division and Exocytosis Capabilities

Research, Год журнала: 2025, Номер 8

Опубликована: Янв. 1, 2025

The first challenge in building a living robotic system inspired by life evolution is how to replicate the original form of life-the cell. However, current microrobots mimic cell motion control but fail functional biological activities cellular systems. Here, we propose strategy that programs microparticle swarms encapsulated droplets at an air/liquid interface create cell-mimetic droplet with vitality employing alternating magnetic fields. Through design algorithms and spontaneous waves, our collective embodies reversible transitions between gas, chain, array, disk-like modes, emulates various complex cells nature, including division exocytosis. Based on these 2 capabilities learned from cells, navigate bile duct gallbladder under guidance fields, completing drug release task. This may provide fundamental understanding pave way for construction artificial Furthermore, they hold substantial potential medical environmental applications.

Язык: Английский

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Micro/nanorobots for remediation of water resources and aquatic life

Frontiers in Bioengineering and Biotechnology, Год журнала: 2023, Номер 11

Опубликована: Ноя. 9, 2023

Nowadays, global water scarcity is becoming a pressing issue, and the discharge of various pollutants leads to biological pollution bodies, which further poisoning living organisms. Consequently, traditional treatment methods are proving inadequate in addressing growing demands industries. As an effective eco-friendly method, micro/nanorobots making significant advancements. Based on researches conducted between 2019 2023 field using micro/nanorobots, this paper comprehensively reviews development control from multiple perspectives, including propulsion methods, decontamination mechanisms, experimental techniques, monitoring. Furthermore, highlights current challenges provides insights into future industry, providing guidance control.

Язык: Английский

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Chemical magnetism – surface force to move motors

Physical Chemistry Chemical Physics, Год журнала: 2024, Номер 26(37), С. 24542 - 24552

Опубликована: Янв. 1, 2024

If redox reactions occur on the surface of a motor and current loop arises, then in non-uniform magnetic field, addition to usual force, such will also be affected by chemical force. The force belongs class forces. Here we analyze for first time properties magnets, which consist three dissimilar metals, as well field generated magnet using paramagnetic nanoparticles. results study show that depends concentration type electrolyte, pH solution, temperature, structure magnet. obtained can contribute creation devices where energy is directly converted into kinetic motion.

Язык: Английский

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