Bilayer Scaffolds Synergize Immunomodulation and Rejuvenation via Layer‐Specific Release of CK2.1 and the “Exercise Hormone” Lac‐Phe for Enhanced Osteochondral Regeneration DOI Open Access

Po‐Lin Liu,

Shu‐Hang He,

Zhi‐Han Shen

и другие.

Advanced Healthcare Materials, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 12, 2024

Repairing osteochondral defects necessitates the intricate reestablishment of microenvironment. The cartilage layer consists a porous gelatin methacryloyl hydrogel (PGelMA) covalently crosslinked with chondroinductive peptide CK2.1 via "linker" acrylate-PEG-N-hydroxysuccinimide (AC-PEG-NHS). This is optimized for remodeling senescent microenvironment in region, thereby establishing regenerative that supports chondrogenesis. For bone layer, silk fibroin (SilMA) coated onto three dimensional (3D)-printed 45S5 bioactive glass scaffold (BG scaffold). "exercise hormone" N-lactoyl-phenylalanine (Lac-Phe) loaded SilMA, endowing it diversified functions to regulate osteogenic Systematic analysis vitro reveals PGelMA-CK2.1 shifts from pro-inflammatory into an anti-inflammatory condition, and alleviates cellular senescence, thus modifying improve recruitment, proliferation chondral differentiation marrow mesenchymal stem cells (BMSCs). enhances microvascular endothelial cell proliferation, migration, angiogenic activities, which, couple increased BMSC recruitment regulatory mechanisms directing differentiation, favor shift "osteogenesis-adipogenesis" balance toward enhanced osteogenesis. In vivo, found this biphasic biomimetic favors simultaneous dual tissue regeneration. approach facilitates development scaffolds holds great potential clinical application.

Язык: Английский

Intrinsic immunomodulatory hydrogels for chronic inflammation DOI

Yuna Qian,

Jiayi Ding,

Rui Zhao

и другие.

Chemical Society Reviews, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

This tutorial review presents the development of advanced immunomodulatory hydrogels strategically designed to address chronic inflammation through their intrinsic properties.

Язык: Английский

Процитировано

11

Macromolecular Poly(N‐isopropylacrylamide) (PNIPAM) in Cancer Treatment and Beyond DOI Creative Commons

Siddhi Throat,

Sankha Bhattacharya

Advances in Polymer Technology, Год журнала: 2024, Номер 2024(1)

Опубликована: Янв. 1, 2024

Poly(N‐isopropylacrylamide) (PNIPAM) is a versatile polymer known for its phase transition properties, exhibiting lower critical solution temperature (LCST) of approximately 32°C. Below this temperature, PNIPAM hydrophilic, while above it, the becomes hydrophobic, making it ideal thermosensitive drug delivery systems (DDSs). In tissue engineering, provides biocompatible, nontoxic and stimuli‐responsive surface cell culture. Its nature ensures safety in medical applications. enhances biosensing diagnostics through affinity biomolecules, improving accuracy. Widely used hydrogels, smart textiles, soft robotics various applications, adapts to environmental changes. straightforward synthesis allows creation diverse copolymers composites, applicable selective reactions conjugations with fluorescent tags or chemical modifications. PNIPAM’s versatility extends pH‐responsive alternatives, broadening application spectrum. Practical examples include separation water treatment cleaning processes. This discussion explores biomedical particularly cancer treatment, photothermal therapy (PTT) photodynamic (PDT), gene imaging. Additionally, highlights noncancerous such as small interfering RNA (siRNA) targeting oncogenes detailed imaging deep tumour tissues.

Язык: Английский

Процитировано

11

A review of recent advances in drug loading, mathematical modeling and applications of hydrogel drug delivery systems DOI
Xiaohan Hu,

Chenyun Zhang,

Yingshuo Xiong

и другие.

Journal of Materials Science, Год журнала: 2024, Номер 59(32), С. 15077 - 15116

Опубликована: Авг. 1, 2024

Язык: Английский

Процитировано

9

Nanomedicines as a cutting-edge solution to combat antimicrobial resistance DOI Creative Commons
Raghu Solanki, Nilesh Makwana, Rahul Kumar

и другие.

RSC Advances, Год журнала: 2024, Номер 14(45), С. 33568 - 33586

Опубликована: Янв. 1, 2024

Antimicrobial mechanism of nanomaterials to combat AMR.

Язык: Английский

Процитировано

9

PhotoChem Interplays: Lighting the Way for drug delivery and diagnosis DOI
Asmita Banstola, Zuan‐Tao Lin, Yongli Li

и другие.

Advanced Drug Delivery Reviews, Год журнала: 2025, Номер 219, С. 115549 - 115549

Опубликована: Фев. 20, 2025

Язык: Английский

Процитировано

1

Preparation schemes and applications of multifunctional PVA composite hydrogels DOI
Yunge Liu, Jing Zhang, Dianyu Wang

и другие.

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160946 - 160946

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

1

Sandwich‐Structured Organogel with Asymmetric‐Adhesion and Adaptive Optical Regulation for Simultaneous Sensing of Human Motion and Temperature Without Interference DOI Open Access

Sijia Ge,

Shinian Liu,

Ying Kong

и другие.

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 3, 2025

Abstract The application of these NIPAm‐based temperature‐sensitive hydrogels in wearable sensing is limited by the inability to achieve a long‐lasting temperature response and adaptive optical regulation due water loss hydrogel, avoid phenomenon detachment external touch, mutual interference between stress signals. Here, sandwich‐structured organogel sensors (SOGS) are prepared based on solvent modulation interfacial fusion cross‐linking strategies asymmetric‐adhesion, regulation, simultaneous human motion without Modulation properties through hydrogen bonding glycol amide groups for long‐term (10–30 °C) infrared ultraviolet regulation. Adhesive conductive introduced under an strategy unilateral adhesion (67.28 kPa pig skin) sensing. intermediate layer prevents In conclusion, provides new idea developing novel responsive gels, facile method unilaterally adherent, interference‐resistant, multifunctional sensors.

Язык: Английский

Процитировано

1

Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications DOI Open Access

Wenguang Dou,

Xiaojun Zeng,

Shuzhuang Zhu

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(16), С. 9100 - 9100

Опубликована: Авг. 22, 2024

The impressive adhesive capacity of marine mussels has inspired various fascinating designs in biomedical fields. Mussel-inspired injectable hydrogels, as a type promising mussel-inspired material, have attracted much attention due to their minimally invasive property and desirable functions provided by components. In recent decades, hydrogels been designed widely applied numerous rational incorporation catechol groups endows the with potential exhibit many properties, including tissue adhesiveness self-healing, antimicrobial, antioxidant capabilities, broadening applications this review, we first give brief introduction adhesion mechanism characteristics hydrogels. Further, typical design strategies are summarized. methodologies for integrating into polymers crosslinking methods discussed section. addition, systematically overview applications, focus on how unique properties these benefit challenges perspectives last This review may provide new inspiration novel bioinspired facilitate application

Язык: Английский

Процитировано

5

A universal strategy to prepare reversible bacteria-killing and bacteria-releasing textiles with nice antifouling ability for long-term service via LBL assembly of modified CMC DOI Creative Commons
Xue Yang,

Yunhui Xu,

Lu Cai

и другие.

Industrial Crops and Products, Год журнала: 2025, Номер 225, С. 120463 - 120463

Опубликована: Янв. 11, 2025

Язык: Английский

Процитировано

0

External Stimuli-Driven Catalytic Hydrogels for Biomedical Applications DOI
Jing Liao,

Jing-Xi Sun,

Wencong Jia

и другие.

Chemical Communications, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

This review discusses design strategies for external stimuli-driven hydrogels with in situ catalytic processes. It highlights precise control over the properties, elucidating regulatory mechanisms and deepening understanding of applications.

Язык: Английский

Процитировано

0