Results in Chemistry,
Год журнала:
2024,
Номер
7, С. 101538 - 101538
Опубликована: Янв. 1, 2024
Furocoumarins,
a
distinct
class
of
coumarins,
hold
diverse
therapeutic
potential
such
as
anti-inflammatory,
anticancer,
antiviral,
antidepressant,
and
more.
Focusing
on
the
past
seven
years,
review
highlights
transition
metal-free
synthesis
furo[3,2-c]coumarin
scaffolds.
Metal-free
responses
have
gained
popularity
because
growing
awareness
need
to
preserve
natural
resources
lessen
negative
effects
metal
usage
environment.
By
categorizing
techniques
into
two-component
reactions
MCRs,
provides
structured
understanding
these
synthetic
methodologies.
Asian Journal of Organic Chemistry,
Год журнала:
2023,
Номер
12(3)
Опубликована: Фев. 3, 2023
Abstract
Spirocyclic
compounds,
particularly
spirooxindoles
that
comprise
a
tetrahedral
sp
3
‐hybridized
carbon
atom
at
the
C‐3
position
of
an
orthogonally
shaped
bicyclic
structure
have
recently
received
increasing
attention
in
drug
discovery
and
development,
besides
their
major
potential
natural
products
synthetic
organic
chemistry.
They
are
found
to
be
structural
constituents
many
alkaloids,
key
active
building
blocks
for
construction
various
pharmaceutically
significant
molecules.
On
other
hand,
with
awareness
people
about
protecting
health
living
environment
from
pollution
caused
by
chemical
laboratories
industry,
development
method
provides
alternatives
traditional
one
introducing
economical
sustainable
processes
is
scientifically
technically
demanding
but
challenging.
To
address
these
concerns
inspired
photosynthesis
process,
visible
light‐induced
chemistry
appears
highly
economic,
sustainable,
alternative
approach
synthesis.
The
present
mini‐review
aims
highlight
recent
progress
accomplished
straightforward
accelerated
light
irradiation
period
2015
date.
Besides
reviewing
advantages
achieved
this
field,
we
also
attempt
find
out
drawback,
mechanistic
rationalization,
scopes
future
applications.
Abstract
The
synthesis
of
novel
nitrogen‐containing
heterocycles
as
a
result
their
frequent
existence
in
natural
products,
commercially
available
drugs,
and
optoelectronic
materials
is
extremely
demanding
but
challenging
due
to
the
involvement
toxic
solvents,
sometimes
transition‐metal
catalyst(s)
which
are
often
associated
with
environmental
safety
concerns.
1,4‐dihydropyridine
(1,4‐DHP),
synthetic
origin,
among
one
privileged
classes
heterocycles,
representing
broad
spectrum
pharmaceutical
properties,
has
received
considerable
interest
medicinal
organic
chemistry.
Recognizing
prominent
significance
this
structural
motif,
substantial
efforts
have
been
paid
not
only
for
expedient
also
discovery
complex
molecules
by
using
them
key
active
building
blocks.
However,
developing
elegant
processes
provides
effortless
access
1,4‐dihydropyridines
exploring
environmentally
friendly
conditions
primary
goal
lowering
expenditure
overall
process
challenging.
In
mini‐review
article,
we
demonstrated
clear
presentation
recent
transition‐metal‐free
catalyzed
potential
therapeutic
interests
covered
literature
from
2015
date.
ACS Omega,
Год журнала:
2022,
Номер
7(40), С. 36028 - 36036
Опубликована: Сен. 29, 2022
For
the
first
time,
an
eco-friendly
and
efficient
one-pot
green
multicomponent
approach
has
been
described
to
synthesize
functionalized
trans-2,3-dihydrofuro[3,2-c]coumarins
(DHFCs).
In
this
synthesis,
imidazole
water
were
used
as
catalyst
solvent,
respectively,
under
mild
conditions.
Applications
of
developed
catalytic
process
in
a
medium
revealed
outstanding
activity,
productivity,
broad
functional
group
tolerance,
affording
series
newly
designed
DHFC
derivatives
excellent
yields
(72-98%).
Moreover,
human
serum
albumin
(HSA)
binding
ability
synthesized
uncovered
through
detailed
silico
vitro-based
structure-activity
analysis.
The
bind
HSA,
most
abundant
protein,
low
micromolar
ranges
unequivocally
reflects
suitable
absorption,
distribution,
metabolism,
elimination
profile
compounds,
which
may
further
be
envisaged
for
their
therapeutic
usage
endeavors.
Frontiers in Chemistry,
Год журнала:
2022,
Номер
10
Опубликована: Сен. 14, 2022
Quinazolinone,
a
bicyclic
compound,
comprises
pyrimidine
ring
fused
at
4´
and
8´
positions
with
benzene
constitutes
substantial
class
of
nitrogen-containing
heterocyclic
compounds
on
account
their
frequent
existence
in
the
key
fragments
many
natural
alkaloids
pharmaceutically
active
components.
Consequently,
tremendous
efforts
have
been
subjected
to
elegant
construction
these
recently
received
immense
interest
synthetic
medicinal
chemistry.
The
domain
organic
chemistry
has
grown
significantly
over
past
few
decades
for
highly
functionalized
therapeutically
potential
complex
molecular
structures
aid
small
molecules
by
replacing
transition-metal
catalysis.
rapid
access
this
heterocycle
means
organocatalytic
strategy
provided
new
alternatives
from
viewpoint
green
In
review
article,
we
demonstrated
clear
presentation
recent
synthesis
quinazolinones
therapeutic
interests
covered
literature
2015
date.
addition
these,
understanding
mechanistic
aspects,
features,
limitations
developed
reaction
methodologies
highlighted.
Bulletin of the Chemical Society of Japan,
Год журнала:
2022,
Номер
95(7), С. 1016 - 1024
Опубликована: Май 9, 2022
Abstract
The
development
of
highly-functional
visible
light-driven
hybrid
catalysts
(B12-Mn+/TiO2)
prepared
from
B12
complexes
(B12)
derived
natural
vitamin
B12,
earth-abundant
metal
ions
(Mn+),
and
titanium
oxide
(TiO2)
was
reported.
ions,
such
as
Cu2+,
Ni2+,
Fe2+,
Zn2+,
Mn2+,
Al3+,
Mg2+,
were
modified
on
the
surface
TiO2
(2.4
×
10−5–9.9
10−5
mol/g)
to
obtain
effective
response
light,
complex
also
loaded
(6.2
10−6–1.1
produce
a
catalyst.
Amide
formations
dichlorodiphenyltrichloroethane
(DDT)
catalyzed
by
B12-Mn+/TiO2
proceeded
in
up
89%
yields
presence
triethylamine
(NEt3)
under
light
irradiation
(λ
≧
420
nm)
air
at
room
temperature.
These
could
be
classified
into
two
groups
based
these
reactivities,
it
found
that
B12-Mg2+/TiO2
showed
most
catalytic
activities
all
samples.
syntheses
fine
chemicals,
N,N-diethyl-3-methylbenzeamide
(DEET),
N,N-diethylcyanoformamide,
corresponding
trichloromethyl
compounds
(FG-CCl3)
with
about
80%
yields.
Frontiers in Chemistry,
Год журнала:
2022,
Номер
9
Опубликована: Янв. 11, 2022
A
short
and
efficient
multicomponent
sequence
for
synthesizing
fused
novel
polyheterocyclic
chromeno
spiro-pyrrolidine
oxindoles
via
1,3-dipolar
cycloaddition
reaction
mediated
by
reactive
azomethine
ylides
catalyzed
the
Graphene
Oxide
(GO)
is
reported
herein.
This
approach
was
utilized
spiro-pyrrolothiazole
spiro-pyrrole
with
yields
ranging
from
good
to
excellent.
heterogeneous
GO
catalyst
an
ultra-low
catalytic
loading
of
0.05
wt%
could
proficiently
catalyze
without
formation
any
side
products
can
also
be
visualized
solid
mass
in
flask.
The
methodology
green
nature
were
isolated
simple
filtration
use
chromatographic
techniques.
Chemical Science,
Год журнала:
2023,
Номер
14(42), С. 11850 - 11857
Опубликована: Янв. 1, 2023
We
present
a
multicomponent
reaction
catalyzed
by
Pd/amine/Brønsted
acid
ternary
system.
The
approach
facilitates
the
synthesis
of
substituted
4-hydroxycoumarin
derivatives
with
adjacent
quaternary
and
tertiary
stereocenters
through
assembly
two
in
situ
generated
active
intermediates.
