Results in Chemistry,
Год журнала:
2024,
Номер
7, С. 101538 - 101538
Опубликована: Янв. 1, 2024
Furocoumarins,
a
distinct
class
of
coumarins,
hold
diverse
therapeutic
potential
such
as
anti-inflammatory,
anticancer,
antiviral,
antidepressant,
and
more.
Focusing
on
the
past
seven
years,
review
highlights
transition
metal-free
synthesis
furo[3,2-c]coumarin
scaffolds.
Metal-free
responses
have
gained
popularity
because
growing
awareness
need
to
preserve
natural
resources
lessen
negative
effects
metal
usage
environment.
By
categorizing
techniques
into
two-component
reactions
MCRs,
provides
structured
understanding
these
synthetic
methodologies.
Current Organic Chemistry,
Год журнала:
2024,
Номер
28(20), С. 1593 - 1604
Опубликована: Июль 12, 2024
:
This
study
outlines
the
development
of
a
novel
approach
utilizing
microwave
assistance
for
alcohol
dehydrogenative
reaction.
The
process
is
catalyzed
by
manganese
(II)
and
cobalt
in
conjunction
with
chroman-4-one
amino
ligands.
research
introduces
unique
catalytic
system
capable
synthesizing
various
heterocyclic
compounds,
including
pyrroles,
pyridines,
Betti
bases,
chromenes,
coumarins
via
dehydrogenation.
synthesis
involved
preparation
characterization
series
chroman-
4-one
ligands
(C1-C6)
using
standard
analytical
techniques.
These
ligands,
combination
MnCl2‧4H2O
CoCl2,
demonstrated
remarkable
activity,
effectively
driving
cycle
was
initiated
in-situ
formation
metal
complexes
during
Characterization
ESI-MS
confirmed
presence
(Int-1)
other
intermediates
(Int-II
Int-III)
throughout
cycle.
Additionally,
controlled
experiment
corroborated
efficacy
system,
evidenced
evolution
H2
gas.
European Journal of Organic Chemistry,
Год журнала:
2022,
Номер
26(6)
Опубликована: Дек. 23, 2022
Abstract
Direct
and
selective
C(sp
2
)−H/C(sp
)−H
cross‐dehydrogenative
coupling
has
become
a
promising
strategy
to
increase
molecular
complexity
with
high
atom
economy.
This
study
describes
an
efficient
straightforward
protocol
for
the
regioselective
C
3
‐H/C
‐H
cross‐coupling
of
4‐hydroxycoumarin
derivatives
quinoxalin‐2(1
H
)‐ones,
including
late‐stage
modification
natural
drugs,
promoted
by
visible
light
under
aerobic
conditions
at
room
temperature.
With
this
approach,
wide
range
hybrid
drug‐like
molecules
were
prepared,
using
air
as
terminal
oxidant.
Remarkably,
4
‐OH
group
coumarin
ring
is
essential
reaction
been
used
handle
diverse
functionalizations
final
products.
Moreover,
sunlight
can
promote
very
mild
sustainable
conditions,
even
on
gram
scale.
Qualitative
semi‐quantitative
tools
demonstrate
greenness
advance
methodology
over
previously
reported
ones.
Several
experiments
conducted
propose
plausible
mechanism
transformation.
Abstract
Constant
mutations
of
SARS‐CoV‐2
from
2019
to
the
present
commences
potential
dilemma
efficacy
developed
COVID‐19
antiviral
drugs.
In
this
current
report,
series
3‐phenyl(alkylamino)methyl‐4‐hydroxycoumarin
was
identified
as
compounds
drug‐likeliness
that,
through
molecular
docking
simulations,
also
demonstrated
favourable
binding
different
sites
RBD/hACE2
complex.
This
achieved
by
varying
chain
alkyl
length
and
substituent
phenyl
moiety.
The
subjected
were
successfully
synthesized
a
catalyst‐free
multicomponent
condensation
reaction
4‐hydroxycoumarin,
p‐substituted
benzaldehyde,
linear
amines
in
dichloromethane
(DCM)
at
22
°C.
crude
products
moderate
(40–50
%)
very
good
(80–90
yield
with
excellent
purity
without
need
for
chemical
purification
verified
nuclear
magnetic
resonance
(NMR)
spectroscopy.
simple
method
produce
preliminary
results
an
opportunity
advancement
drug
discovery.
Results in Chemistry,
Год журнала:
2024,
Номер
7, С. 101538 - 101538
Опубликована: Янв. 1, 2024
Furocoumarins,
a
distinct
class
of
coumarins,
hold
diverse
therapeutic
potential
such
as
anti-inflammatory,
anticancer,
antiviral,
antidepressant,
and
more.
Focusing
on
the
past
seven
years,
review
highlights
transition
metal-free
synthesis
furo[3,2-c]coumarin
scaffolds.
Metal-free
responses
have
gained
popularity
because
growing
awareness
need
to
preserve
natural
resources
lessen
negative
effects
metal
usage
environment.
By
categorizing
techniques
into
two-component
reactions
MCRs,
provides
structured
understanding
these
synthetic
methodologies.
