Electrochemical Aminotrifluromethylation of Unactivated Alkenes with Langlois’ Reagent as the CF3 Source DOI

Tongshun An,

Xiaowen Qin, Chenwei Liu

и другие.

New Journal of Chemistry, Год журнала: 2023, Номер 48(5), С. 2183 - 2187

Опубликована: Дек. 26, 2023

An electrochemical approach for synthesizing various trifluoromethylated pyrrolidines was developed by utilizing Langlois’ reagent as the CF 3 source, and different unactivated alkenes can be converted to corresponding heterocycles in 43–80% yields.

Язык: Английский

Electrochemical Trifluoromethylation and Sulfonylation of N-Allylamides: Synthesis of Oxazoline Derivatives DOI
Shujun Chen, Weiqiang Zhong, Jing‐Mei Huang

и другие.

The Journal of Organic Chemistry, Год журнала: 2023, Номер 88(17), С. 12630 - 12640

Опубликована: Авг. 14, 2023

We report a new method for the synthesis of trifluoromethylated and sulfonylated oxazolines by electrochemical radical cascade cyclizations N-allylamides with sodium trifluoromethanesulfinate or sulfonylhydrazines. This protocol provides green useful strategy to synthesize broad substrate scope under ambient conditions.

Язык: Английский

Процитировано

7
Iodine(iii)-promoted oxidative carbotrifluoromethylation of maleimides with imidazopyridines and Langlois’ reagent DOI

Dipti Lai,

Suvam Bhattacharjee,

Saurodeep Mandal

и другие.

Chemical Communications, Год журнала: 2024, Номер 60(16), С. 2232 - 2235

Опубликована: Янв. 1, 2024

Herein, we report a metal-free protocol for oxidative carbotrifluoromethylation of maleimides with imidazopyridines and Langlois’ reagent using PIDA as an oxidant.

Язык: Английский

Процитировано

2
Recent Advances in the Electrochemical Functionalization of Imidazoheterocycles DOI
Sifeng Li

Advanced Synthesis & Catalysis, Год журнала: 2024, Номер unknown

Опубликована: Окт. 18, 2024

Abstract Imidazoheterocycles have extensive applications in the pharmaceutical industry and agrochemicals. A comprehensive overview has been provided on current advancements electrochemical functionalization of imidazo‐fused heterocycles, which classified into ten different types reactions. Electrochemical synthesis emerged as a highly effective method for producing organic molecules, especially context sustainable development. Employing electrons traceless oxidant, several C−H reactions heterocycles achieved at either C3 or C5 positions. Electrons may serve reducing agent to synthesize pyridine rings that are partially fully saturated imidazo[1,2‐ ]pyridines. The purpose review is attract interest scientific community promote additional research imidazoheterocycles using methods.

Язык: Английский

Процитировано

1
Metal‐Free Regioselective Oxidative C−H Trifluoromethylation of Imidazothiazoles and Their Antitubercular Activity DOI

Nagaraju Chirra,

Varshitha Shanigarapu,

Ravi Kumar Pedapati

и другие.

ChemistrySelect, Год журнала: 2024, Номер 9(12)

Опубликована: Март 21, 2024

Abstract Here we report a metal‐free direct C−H trifluoromethylation of the imidazothiazoles 7(a – ad) using sodium triflouromethanesulfinate (Langlois’ reagent) and tert ‐butyl hydroperoxide (TBHP) as an oxidant. The control studies show that protocol follows radical reaction pathway provides excellent yields trifluoromethylated products 9(a with broad substrate scope regioselective operation. Moreover, newly synthesized compounds exhibit promising antimycobacterial activity.

Язык: Английский

Процитировано

0
Transition-metal-free synthesis of triarylmethanes via Friedel-Crafts reactions of imidazo[1,2-a]pyridines with chlorohydrocarbon derivatives DOI Creative Commons

Xinlei Fu,

Longhui Wu,

Xiaohua Guo

и другие.

Journal of Saudi Chemical Society, Год журнала: 2024, Номер 28(4), С. 101883 - 101883

Опубликована: Май 29, 2024

A facile, transition-metal-free, HFIP-promoted method for the synthesis of triarylmethanes through direct Friedel-Crafts reactions imidazo[1,2-a]pyridines with chlorohydrocarbon derivatives has been described, which allows efficient containing in good to satisfactory yields at room temperature. This transformation features simple operation, excellent functional group tolerance, and a broad substrate scope.

Язык: Английский

Процитировано

0
Electrochemical Aminotrifluromethylation of Unactivated Alkenes with Langlois’ Reagent as the CF3 Source DOI

Tongshun An,

Xiaowen Qin, Chenwei Liu

и другие.

New Journal of Chemistry, Год журнала: 2023, Номер 48(5), С. 2183 - 2187

Опубликована: Дек. 26, 2023

An electrochemical approach for synthesizing various trifluoromethylated pyrrolidines was developed by utilizing Langlois’ reagent as the CF 3 source, and different unactivated alkenes can be converted to corresponding heterocycles in 43–80% yields.

Язык: Английский

Процитировано

0