Dearomatization of Aromatic Compounds: A Decade Review
Asian Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 28, 2025
Abstract
Dearomatization
offers
an
efficient
strategy
for
directly
converting
arenes
into
cyclic
molecules.
In
this
review,
we
discuss
representative
examples
of
dearomatization
reactions
through
five
modes:
(1)
radical
dearomatization,
(2)
halofunctionalization‐dearomatization,
in
which
three‐membered
intermediates
were
frequently
involved,
(3)
nucleophilic
mainly
about
electron‐rich
arenes,
(4)
oxidative
and
(5)
reductive
dearomatization.
Compared
to
heteroarenes,
simple
benzene
are
more
challenging
participate
reactions.
recent
years,
fewer
reports
have
focused
on
benzene.
Heteroarenes,
inherently
or
easily
activated,
tend
undergo
readily.
This
review
highlights
a
decade
progress
including
indoles,
benzofurans,
benzothiophenes,
thiophenes,
furans,
naphthols,
naphthalenes,
quinolines,
pyridines,
nitrobenzenes,
benzenes.
It
also
analyzes
their
mechanisms
strategies.
We
hope
will
aid
future
research
field.
Язык: Английский
Regioselective Reversal in One-Pot and Two-Step Reaction of 1-(2-Hydroxyphenyl)-Propargyl Alcohols with Aryl/Alkyl Mercaptan: Construction of 3-(Alkylthio)benzofurans and 2-(Alkylthiomethyl)benzofurans Starting from Identical Materials
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 7, 2024
The
Cu(MeCN)4PF6-catalyzed
reaction
of
1-(2-hydroxyphenyl)-propargyl
alcohols
with
aryl/alkyl
mercaptan
and
subsequent
treatment
K2CO3
only
offered
3-(alkylthio)benzofurans,
whereas
the
stoichiometric-exceeding
CuI-mediated
DIPEA
furnished
2-(alkylthiomethyl)benzofurans
high
selectivity.
amount
Cu(I)
salts
plays
a
key
role
in
selective
formation.
This
unique
protocol
for
construction
two
series
benzofurans
containing
alkylthio
group
proved
to
be
suitable
broad
substrates
1
2
except
aliphatic
alkynyl
alcohols.
Язык: Английский