Examining multimorbidity contributors to dementia over time
Alzheimer s & Dementia,
Год журнала:
2025,
Номер
21(2)
Опубликована: Фев. 1, 2025
Abstract
INTRODUCTION
Multimorbidity
is
associated
with
increased
risk
of
dementia,
but
previous
estimation
the
joint
contribution
constituent
conditions
to
dementia
incidence
did
not
model
additive
contributions
or
temporal
proximity
in
sequential
onset
conditions.
METHODS
Data
were
analyzed
from
9944
Health
and
Retirement
Study
participants
Medicare
fee‐for‐service
beneficiaries,
ages
68–99,
without
Alzheimer's
disease
related
dementias
(ADRD)
at
baseline,
1998–2016.
ADRD
chronic
condition
encoded
using
validated
claims
algorithms.
We
estimated
absolute
eight
longitudinal
extension
average
attributable
fraction
(LE‐AAF).
RESULTS
Hypertension,
acute
myocardial
infarction,
atrial
fibrillation,
diabetes,
heart
failure,
ischemic
disease,
stroke,
arthritis
additively
accounted
for
71.8%
(95%
confidence
interval
[CI]:
62.9%–79.1%)
incident
cases
based
on
LE‐AAF.
DISCUSSION
Our
findings
suggest
that
multimorbidity
plays
a
pivotal
role
incidence.
Targeting
constituents
cardiovascular
path
may
contribute
most
lowering
risk.
Highlights
Most
(71.8%)
Hypertension
was
largest
contributor
Confidence
intervals
smallest
dementia.
Longitudinal
fractions
(LE‐AAFs)
explicitly
consider
patterns
comorbidities.
Acute
infarction
significantly
Язык: Английский
Crosstalk between bone and brain in Alzheimer's disease: Mechanisms, applications, and perspectives
Alzheimer s & Dementia,
Год журнала:
2024,
Номер
20(8), С. 5720 - 5739
Опубликована: Июнь 2, 2024
Abstract
Alzheimer's
disease
(AD)
is
a
neurodegenerative
that
involves
multiple
systems
in
the
body.
Numerous
recent
studies
have
revealed
bidirectional
crosstalk
between
brain
and
bone,
but
interaction
bone
AD
remains
unclear.
In
this
review,
we
summarize
human
of
association
provide
an
overview
their
interactions
underlying
mechanisms
AD.
We
review
effects
on
from
aspects
pathogenic
proteins,
risk
genes,
neurohormones,
neuropeptides,
neurotransmitters,
brain‐derived
extracellular
vesicles
(EVs),
autonomic
nervous
system.
Correspondingly,
elucidate
involvement
pathogenesis
AD,
including
bone‐derived
hormones,
marrow‐derived
cells,
EVs,
inflammation.
On
basis
brain,
propose
potential
strategies
for
management
with
hope
offering
novel
perspectives
its
prevention
treatment.
Highlights
The
along
consequent
changes
may
involve
disturbing
homeostasis.
Degenerative
disorders
influence
progression
through
series
pathophysiological
mechanisms.
Therefore,
relevant
intervention
be
beneficial
comprehensive
Язык: Английский
The potential link between the development of Alzheimer’s disease and osteoporosis
Biogerontology,
Год журнала:
2025,
Номер
26(1)
Опубликована: Янв. 20, 2025
Язык: Английский
Unraveling the impact of blood RANKL and OPG levels on Alzheimer's disease: Independent of bone mineral density and inflammation
Alzheimer s & Dementia Translational Research & Clinical Interventions,
Год журнала:
2025,
Номер
11(1)
Опубликована: Янв. 1, 2025
Язык: Английский
Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances
Signal Transduction and Targeted Therapy,
Год журнала:
2025,
Номер
10(1)
Опубликована: Март 10, 2025
Abstract
In
the
context
of
global
ageing,
prevalence
neurodegenerative
diseases
and
dementia,
such
as
Alzheimer’s
disease
(AD),
is
increasing.
However,
current
symptomatic
disease-modifying
therapies
have
achieved
limited
benefits
for
in
clinical
settings.
Halting
progress
neurodegeneration
cognitive
decline
or
even
improving
impaired
cognition
function
are
clinically
meaningful
goals
treatments
diseases.
Ageing
primary
risk
factor
their
associated
comorbidities,
vascular
pathologies,
elderly
individuals.
Thus,
we
aim
to
elucidate
role
ageing
from
perspective
a
complex
system,
which
brain
core
peripheral
organs
tissues
form
holistic
network
support
functions.
During
progressive
deterioration
structure
entire
body
hampers
its
active
adaptive
responses
various
stimuli,
thereby
rendering
individuals
more
vulnerable
Consequently,
propose
that
prevention
treatment
should
be
grounded
antiageing
rejuvenation
means
complemented
by
interventions
targeting
disease-specific
pathogenic
events.
This
integrated
approach
promising
strategy
effectively
prevent,
pause
slow
down
progression
Язык: Английский
Relationships among osteoporosis, redox homeostasis, and alcohol addiction: Importance of the brain-bone axis
Biomedicine & Pharmacotherapy,
Год журнала:
2025,
Номер
187, С. 118063 - 118063
Опубликована: Апрель 19, 2025
Язык: Английский
Impact of dementia and mild cognitive impairment on bone health in older people
Aging Clinical and Experimental Research,
Год журнала:
2024,
Номер
37(1)
Опубликована: Дек. 27, 2024
Mild
cognitive
impairment,
dementia
and
osteoporosis
are
common
diseases
of
ageing
and,
with
the
increasingly
global
population,
increasing
in
prevalence.
These
conditions
closely
associated,
shared
risk
factors,
underlying
biological
mechanisms
potential
direct
causal
pathways.
In
this
review,
epidemiological
mechanistic
links
between
mild
skeletal
health
explored.
Discussion
will
focus
on
how
changes
brain
bone
signalling
can
underly
associations
these
conditions,
consider
molecular
cellular
drivers
context
inflammation
gut
microbiome.
There
is
a
complex
interplay
nutritional
changes,
which
may
precede
or
follow
onset
impairment
(MCI)
dementia,
health.
Polypharmacy
patients
MCI
there
difficult
prescribing
decisions
to
be
made
due
elevated
falls
associated
many
drugs
used
for
problems,
consequently
increase
fracture
risk.
Some
medications
prescribed
directly
impact
addition,
have
difficulty
remembering
medication
without
assistance,
meaning
that
but
not
taken.
Cognitive
improved
delayed
by
physical
activity
exercise,
evidence
additional
benefits
fractures.
Research
gaps
priorities
aim
reducing
burden
fractures
people
also
discussed.
Язык: Английский