Emerging mechanisms of organ crosstalk: The role of oxylipins DOI Creative Commons
Helena L. Fisk, Saame Raza Shaikh

Nutrition Bulletin, Год журнала: 2024, Номер unknown

Опубликована: Дек. 10, 2024

There is growing interest in the role of oxylipins pathophysiology several diseases. This accompanied by a limited but evolving evidence base describing augmented oxylipin concentrations range complications including cardiovascular disease, obesity, liver disease and neurological disorders. Despite this, literature profiles blood multiple organs inconsistent mechanisms which these are altered, relationships between localised tissue circulating poorly understood. Inflammation immune response associated with requires communication across physiological systems. For example, inflammation comorbidities obesity extend beyond adipose affect vascular, hepatobiliary digestive systems amongst others. Communication implicated progression as well maintenance homeostasis. emerging for mechanism organ crosstalk orchestrating system responses Herein, we review to support describe via cardiosplenic gut-link axis. In addition, regulation, gut microbiome modification using nutritional intervention. Finally, future perspectives addressing challenges measurement interpretation research focus on host genome modifier dietary lipid

Язык: Английский

The link between gut microbiome and Alzheimer's disease: From the perspective of new revised criteria for diagnosis and staging of Alzheimer's disease DOI Creative Commons
Yuan Liang, Congcong Liu,

Manman Cheng

и другие.

Alzheimer s & Dementia, Год журнала: 2024, Номер 20(8), С. 5771 - 5788

Опубликована: Июнь 28, 2024

Abstract Over the past decades, accumulating evidence suggests that gut microbiome exerts a key role in Alzheimer's disease (AD). The Association Workgroup is updating diagnostic criteria for AD, which changed profiles and categorization of biomarkers from “AT(N)” to “ATNIVS.” Previously, most studies focus on correlation between amyloid beta deposition (“A”), initial AD pathological feature triggering “downstream” tauopathy neurodegeneration. However, limited research investigated interactions other pathogenesis (“TNIVS”). In this review, we summarize current findings microbial characteristics whole spectrum AD. Then, describe association with updated biomarker categories pathogenesis. addition, outline microbiome‐related therapeutic strategies Finally, discuss issues field future directions. Highlights new revised (AD) proposed by have associations are described. Current summarized. Therapeutic based proposed.

Язык: Английский

Процитировано

10
Modulatory effects of traditional Chinese medicines on gut microbiota and the microbiota-gut-x axis DOI Creative Commons

Tingting Luo,

Qingya Che,

Ziyi Guo

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Окт. 9, 2024

The gut microbiota offers numerous benefits to the human body, including promotion of nutrient absorption, participation in metabolic processes, and enhancement immune function. Recent studies have introduced concept gut-organ axis, which encompasses interactions such as gut-brain gut-liver gut-lung axis. This underscores complex interplay between various organs tissues, brain, heart, lungs, liver, kidneys, muscles, bones. Growing evidence indicates that can influence onset progression multi-organ system diseases through their effects on Traditional Chinese medicine has demonstrated significant efficacy regulating gastrointestinal system, leveraging its unique advantages. Considerable advancements been made understanding role axis within mechanisms action traditional medicine. review aims elucidate roles health, explore potential connections microbiota, examine therapeutic microbiota-gut-organ Furthermore, addresses limitations challenges present current research while proposing directions for future investigations this area.

Язык: Английский

Процитировано

4
Research Progress of Bile Acids in Neurodegenerative Diseases DOI

念 陈

Advances in Clinical Medicine, Год журнала: 2025, Номер 15(02), С. 1718 - 1724

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Infections, Genetics, and Alzheimer's Disease: Exploring the Pathogenic Factors for Innovative Therapies DOI

Ramesh Kordi,

T. John Andrews,

Mark D. Hicar

и другие.

Virology, Год журнала: 2025, Номер unknown, С. 110523 - 110523

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Metagenomic analysis characterizes stage-specific gut microbiota in Alzheimer’s disease DOI
Longhao Jia, Ke Yang,

Shuo Zhao

и другие.

Molecular Psychiatry, Год журнала: 2025, Номер unknown

Опубликована: Март 31, 2025

Язык: Английский

Процитировано

0
Microbiome Dysbiosis as a Driver of Neurodegeneration: Insights into Alzheimer’s and Parkinson’s Diseases DOI Creative Commons

Ana Jagodic,

Antea Kršek,

Lou Marie Salomé Schleicher

и другие.

Gastrointestinal Disorders, Год журнала: 2025, Номер 7(2), С. 28 - 28

Опубликована: Апрель 2, 2025

Microbiome dysbiosis—an imbalance in gut microbial communities—has emerged as a critical factor the pathogenesis of neurological disorders, particularly Alzheimer’s and Parkinson’s diseases. This review examines role microbiota neurodegeneration, emphasizing how dysbiosis disrupts gut–brain communication through mechanisms such impaired permeability, systemic inflammation, neuroinflammation. The gastrointestinal central nervous systems interact bidirectionally, with metabolites like short-chain fatty acids playing pivotal maintaining brain health. Dysbiotic shifts composition can compromise blood–brain barrier, enabling inflammatory molecules to alter biochemistry potentially accelerate neurodegenerative processes. Additionally, this explores therapeutic strategies—including probiotics, prebiotics, dietary modifications—designed restore balance, reduce neuroinflammation, slow disease progression. Further research is essential refine microbiome-targeted therapies fully elucidate their potential managing

Язык: Английский

Процитировано

0
Value of blood neural cell-derived small extracellular vesicles in the diagnosis and prediction of Alzheimer's disease: A systematic revie DOI Creative Commons

Weibing Pan,

Teng Yu,

Xiaowan Han

и другие.

The Journal of Prevention of Alzheimer s Disease, Год журнала: 2025, Номер unknown, С. 100193 - 100193

Опубликована: Май 1, 2025

Blood neural cell-derived small extracellular vesicles (sEVs) can directly reflect changes in brain tissue and are easier to obtain than cerebrospinal fluid. This article systematically reviews the alterations of proteins miRNAs from sEVs patients with Alzheimer's disease (AD), summarizes biomarkers clinical diagnostic predictive value. PubMed, Web Science, Embase, Cochrane Library were searched for studies blood AD up May 2024. According inclusion exclusion criteria, literature was screened, information extracted quality evaluated. Proteins classified summarized, focusing on target molecules high values AD. A final 34 articles reporting 5601 participants included. In cross-sectional studies, Aβ- Tau-related (Aβ42, Aβ42/40, p-S396-Tau, p-Tau181), p-S312-IRS-1, cathepsin D increased, conversely, synaptic (neurogranin, synaptotagmin, synaptophysin, synaptopodin, NMDAR2A) REST decreased neuron-derived (NDsEVs) While miR-29c-3p increased NDsEVs glial sEVs. Each these demonstrated Additionally, astrocyte-derived (ADsEVs) showed complement effector regulatory a moderate longitudinal cohort three composite models displayed efficacy early prediction, could predict occurrence within 1-10 years. Therefore, proteins, miRNA demonstrate serving as important biomarkers. Especially, significant stage, which has

Язык: Английский

Процитировано

0
Gut microbiota and their influence in brain cancer milieu DOI Creative Commons
Bandari BharathwajChetty, Aviral Kumar,

Pranav Deevi

и другие.

Journal of Neuroinflammation, Год журнала: 2025, Номер 22(1)

Опубликована: Май 1, 2025

Microbial communities are not simply remnants of the past but dynamic entities that continuously evolve under selective pressures nature, reflecting intricate and adaptive processes evolution. The microbiota residing in various regions human body has numerous roles different physiological such as nutrition, metabolism, immune regulation, etc. In zeal achieving empirical insights into ambit gut microbiome, research over years led to revelation reciprocal interaction between microbiome cognitive functioning body. Dysbiosis microbial composition disturbs homeostatic This dysbiosis been associated with chronic diseases, including brain cancer, glioma, glioblastoma, review explores mechanistic role dysbiosis-mediated progression cancers their subtypes. Moreover, it demonstrates regulatory metabolites produced by microbiota, short-chain fatty acids, amino lipids, etc., tumour progression. Further, we also provide valuable mediating efficiency therapeutic regimens, thereby leveraging potential biomarkers targets for improved treatment outcomes.

Язык: Английский

Процитировано

0
Novelties on Neuroinflammation in Alzheimer’s Disease–Focus on Gut and Oral Microbiota Involvement DOI Open Access
Cristina Popescu, Constantin Munteanu, Aurelian Anghelescu

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(20), С. 11272 - 11272

Опубликована: Окт. 19, 2024

Recent studies underscore the role of gut and oral microbiota in influencing neuroinflammation through microbiota–gut–brain axis, including Alzheimer’s disease (AD). This review aims to provide a comprehensive synthesis recent findings on involvement neuroinflammatory processes associated with AD, emphasizing novel insights therapeutic implications. reveals that dysbiosis AD patients’ is linked heightened peripheral central inflammatory responses. Specific bacterial taxa, such as Bacteroides Firmicutes gut, well Porphyromonas gingivalis cavity, are notably altered leading significant changes microglial activation cytokine production. Gut alterations increased intestinal permeability, facilitating translocation endotoxins like lipopolysaccharides (LPS) into bloodstream exacerbating by activating brain’s toll-like receptor 4 (TLR4) pathways. Furthermore, microbiota-derived metabolites, short-chain fatty acids (SCFAs) amyloid peptides, can cross blood-brain barrier modulate While microbial amyloids may contribute amyloid-beta aggregation brain, certain SCFAs butyrate exhibit anti-inflammatory properties, suggesting potential avenue mitigate neuroinflammation. not only highlights critical pathology but also offers ray hope modulating could represent strategy for reducing slowing progression.

Язык: Английский

Процитировано

3
Diet Patterns, the Gut Microbiome, Mood Disorders and Alzheimer’s Disease DOI

Virginia Lee

Опубликована: Май 8, 2025

A literature review on When the microbiome helps brain-current evidence, The link between gut and Alzheimer’s disease: From perspective of newly revised criteria for diagnosis staging disease), Relationship microbiota systematic review, disease depression in elderly: trajectory linking serotonin signaling, Modifying diet to prevent manage neurodegenerative diseases, Association probiotics, prebiotics, symbiotic or yogurt supplement brain‐current evidence.

Язык: Английский

Процитировано

0