Lipid-Based Nanoparticles for Drug/Gene Delivery: An Overview of the Production Techniques and Difficulties Encountered in Their Industrial Development

ACS Materials Au, Год журнала: 2023, Номер 3(6), С. 600 - 619

Опубликована: Авг. 21, 2023

Over the past decade, therapeutic potential of nanomaterials as novel drug delivery systems complementing conventional pharmacology has been widely acknowledged. Among these nanomaterials, lipid-based nanoparticles (LNPs) have shown remarkable pharmacological performance and promising outcomes, thus gaining substantial interest in preclinical clinical research. In this review, we introduce main types LNPs used formulations such liposomes, nanoemulsions, solid lipid nanoparticles, nanostructured carriers, polymer hybrid focusing on their physicochemical properties potential. We discuss computational studies modeling techniques to enhance understanding how interact with cargo predict effectiveness interactions applications. also analyze benefits drawbacks various LNP production nanoprecipitation, emulsification, evaporation, thin film hydration, microfluidic-based methods, an impingement jet mixer. Additionally, major challenges associated industrial development, including stability sterilization, storage, regulatory compliance, reproducibility, quality control. Overcoming facilitating compliance represent key steps toward LNP's successful commercialization translation into settings.

Язык: Английский

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Solid lipid nanoparticles and nanostructured lipid carriers: a review of the methods of manufacture and routes of administration

Pharmaceutical Development and Technology, Год журнала: 2022, Номер 27(5), С. 525 - 544

Опубликована: Май 28, 2022

The bioavailability of drugs is dependent on several factors such as solubility and the administration route. A drug with poor aqueous solubility, therefore, poses challenges regards to its pharmaceutical advance ultimately biological usage. Lipid nanoparticles have been used in science due their importance green chemistry. Their biochemical properties ‘green’ materials processes mean they can be environmentally sustainable. Generally, lipid employed carriers for both lipophilic hydrophilic drugs. proposed route present advantages disadvantages which should considered by a formulator. Solid (SLNs) nanostructured (NLCs) are attractive delivery systems because ease manufacture, biocompatibility, biodegradability, scale-up capacity formulation constituents. easy simple scalability novel SLNs nano carriers, along various processing procedures, recent developments, limitation toxicity, optimization approaches manufacture nanoparticles, lyophilization release comprehensively discussed this review. This review also summarizes research data related preparation methods excipients NLCs years.

Язык: Английский

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Current Advances in Lipid Nanosystems Intended for Topical and Transdermal Drug Delivery Applications

Pharmaceutics, Год журнала: 2023, Номер 15(2), С. 656 - 656

Опубликована: Фев. 15, 2023

Skin delivery is an exciting and challenging field. It a promising approach for effective drug due to its ease of administration, handling, high flexibility, controlled release, prolonged therapeutic effect, adaptability, many other advantages. The main associated challenge, however, low skin permeability. healthy barrier that serves as the body's primary defence mechanism against foreign particles. New advances in (both topical transdermal) depend on overcoming challenges with molecule permeation irritation. These limitations can be overcome by employing new approaches such lipid nanosystems. Due their advantages (such easy scaling, cost, remarkable stability) these systems have attracted interest from scientific community. However, successful formulation, several factors including particle size, surface charge, components, etc. understood controlled. This review provided brief overview structure well different pathways nanoparticle penetration. In addition, influencing penetration nanoparticles been highlighted. Applications nanosystems dermal transdermal delivery, regulatory aspects, were critically discussed.

Язык: Английский

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Lipid nanoparticles for siRNA delivery in cancer treatment

Journal of Controlled Release, Год журнала: 2023, Номер 361, С. 130 - 146

Опубликована: Авг. 4, 2023

Язык: Английский

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Lipid Nanoparticles as Delivery Vehicles for Inhaled Therapeutics

Biomedicines, Год журнала: 2022, Номер 10(9), С. 2179 - 2179

Опубликована: Сен. 2, 2022

Lipid nanoparticles (LNPs) have emerged as a powerful non-viral carrier for drug delivery. With the prevalence of respiratory diseases, particularly highlighted by current COVID-19 pandemic, investigations into applying LNPs to deliver inhaled therapeutics directly lungs are underway. The progress in LNP development well recent pre-clinical studies three main classes encapsulated drugs: small molecules, nucleic acids and proteins/peptides will be discussed. advantages pulmonary delivery system such reducing systemic toxicity enabling higher local concentration evaluated together with challenges design considerations improved formulations. This review provides perspective on future prospects LNP-mediated diseases.

Язык: Английский

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Clinical delivery of circular RNA: Lessons learned from RNA drug development

Advanced Drug Delivery Reviews, Год журнала: 2023, Номер 197, С. 114826 - 114826

Опубликована: Апрель 23, 2023

Язык: Английский

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An Overview of Nanoparticle Protein Corona Literature

Small, Год журнала: 2023, Номер 19(36)

Опубликована: Апрель 29, 2023

Abstract The protein corona forms spontaneously on nanoparticle surfaces when nanomaterials are introduced into any biological system/fluid. Reliable characterization of the is, therefore, a vital step in development safe and efficient diagnostic therapeutic nanomedicine products. 2134 published manuscripts reviewed down‐selection 470 papers spanning 2000–2021, comprising 1702 (NP) systems is analyzed. This analysis reveals: i) most studies have been conducted metal oxide nanoparticles; ii) despite their overwhelming presence clinical practice, lipid‐based NPs underrepresented research, iii) use new methods to improve reliability reproducibility research; iv) more specific sources toward personalized medicine; v) careful nanoparticles after formation imperative minimize role aggregation contamination outcomes. As used biomedicine become increasingly prevalent biochemically complex, field research will need focus developing analytical approaches techniques appropriate for each unique formulation. Achieving such nano‐bio interface nanobiotechnologies enable seamless implementation medicine.

Язык: Английский

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Design of experiments in the optimization of nanoparticle-based drug delivery systems

Journal of Controlled Release, Год журнала: 2023, Номер 358, С. 398 - 419

Опубликована: Май 12, 2023

Язык: Английский

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Lipid Nanoparticles: An Effective Tool to Improve the Bioavailability of Nutraceuticals

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(21), С. 15764 - 15764

Опубликована: Окт. 30, 2023

Nano-range bioactive colloidal carrier systems are envisaged to overcome the challenges associated with treatments of numerous diseases. Lipid nanoparticles (LNPs), one extensively investigated drug delivery systems, not only improve pharmacokinetic parameters, transportation, and chemical stability encapsulated compounds but also provide efficient targeting reduce risk toxicity. Over last decades, nature-derived polyphenols, vitamins, antioxidants, dietary supplements, herbs have received more attention due their remarkable biological pharmacological health medical benefits. However, poor aqueous solubility, compromised stability, insufficient absorption, accelerated elimination impede research in nutraceutical sector. Owing possibilities offered by various LNPs, ability accommodate both hydrophilic hydrophobic molecules availability preparation methods suitable for sensitive molecules, loading natural fragile into LNPs offers a promising solution. The primary objective this work is explore synergy between nature nanotechnology, encompassing wide range aimed at encapsulating therapeutic within LNPs.

Язык: Английский

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Solid lipid nanoparticles: An effective lipid-based technology for cancer treatment

Journal of Drug Delivery Science and Technology, Год журнала: 2023, Номер 86, С. 104709 - 104709

Опубликована: Июль 3, 2023

Solid lipid nanoparticles (SLN) are considered at the forefront of nanotechnology's rapidly developing field, with several potential applications in drug delivery and research. SLN possesses promising attributes for reaching goal controlled site-specific hence attracted researchers' wide attention. The present review briefly introduces discusses reasoning behind use over other colloidal carriers, such as emulsions liposomes. Techniques to produce SLN, incorporation, loading capacity, release mechanisms reviewed. Aspects SLNs route administration vivo fate carriers also discussed. incorporating different anti-cancer drugs their effectiveness various cancer therapies is highlighted. mechanism action some commonly used agents provided.

Язык: Английский

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