Graphene-Based Polymeric Microneedles for Biomedical Applications: A Comprehensive Review
ACS Applied Bio Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 10, 2025
Transdermal
drug
delivery
presents
a
promising
noninvasive
approach,
bypassing
first-pass
metabolism
and
gastrointestinal
degradation.
However,
the
stratum
corneum
(SC)
barrier
limits
absorption,
necessitating
development
of
effective
systems.
Microneedles,
particularly
polymer-based
ones,
offer
solution
by
penetrating
SC
while
avoiding
critical
nerves
capillaries.
These
microneedles
are
biodegradable,
nontoxic,
easily
manufacturable,
making
them
highly
attractive
platform
for
transdermal
delivery.
their
clinical
application
remains
limited
due
to
suboptimal
therapeutic
efficacy
slow
release
rates.
Recent
advancements
have
introduced
incorporation
nanodrugs,
such
as
nanoparticles
encapsulated
drugs,
into
enhance
efficiency.
Among
materials
explored,
graphene
its
derivatives,
including
oxide
(GO)
reduced
(rGO),
garnered
significant
attention.
Their
exceptional
mechanical
strength,
electrical
conductivity,
antibacterial
properties
not
only
improve
performance
but
also
rates
biocompatibility.
This
review
synthesizes
current
state
microneedle
technologies,
focusing
on
materials,
fabrication
techniques,
challenges.
It
examines
potential
graphene-based
microneedles,
comparing
traditional
in
terms
efficiency
stability.
The
highlights
key
challenges,
scalability,
biocompatibility,
complexity,
suggests
future
research
directions
address
these
issues.
quantum
dots
(GQDs)
is
identified
avenue
improving
profiles,
stability,
real-time
tracking
diffusion.
Finally,
outlines
emerging
applications,
smart
systems,
biosensing,
monitoring,
urging
further
exploration
unlock
full
graphene-enhanced
settings.
Язык: Английский
Biomaterial-based Drug Delivery Strategies for Oral Mucosa
Colloids and Surfaces B Biointerfaces,
Год журнала:
2025,
Номер
251, С. 114604 - 114604
Опубликована: Март 5, 2025
Язык: Английский
Transdermal Delivery of Superoxide Dismutase Using Polymeric Microneedle Patches to Inhibit Skin Aging
Advanced Therapeutics,
Год журнала:
2024,
Номер
7(12)
Опубликована: Ноя. 12, 2024
Abstract
Skin
aging
is
characterized
by
a
deterioration
of
skin
quality
over
time
resulting
from
physiological
changes
and
oxidative
stress
(OS).
Superoxide
dismutase
(SOD)
an
effective
antioxidant
enzyme
widely
used
as
food
supplement
cosmetic
additive
to
alleviate
OS
retard
aging.
However,
conventional
SOD
delivery
routes
commonly
yield
unsatisfactory
results
due
limited
stability,
compromised
bioavailability,
low
absorption
efficiency
in
the
gastrointestinal
(GI)
tract.
These
issues
are
addressed
developing
SOD‐encapsulated
polymeric
microneedle
(PMN)
patches
for
efficient
transdermal
delivery.
The
use
highly
stable
isolated
hot
spring
microbe
ensures
its
reactivity
throughout
PMN
fabrication
application.
This
vehicle
demonstrated
excellent
effectiveness
through
inhibiting
skin‐aging
promoting
hair
growth
validated
extensive
vivo
experiments
using
D‐galactose
(D‐gal)
induced
aging‐mouse
model.
SOD‐PMNs
promoted
regeneration
follicles,
increased
melanin
synthesis,
decreased
lipid
oxidation,
elevated
antioxidative
capacity
tissue.
success
promises
wide
applicability
pharmaceutical
industries.
Язык: Английский