Transdermal Delivery of Superoxide Dismutase Using Polymeric Microneedle Patches to Inhibit Skin Aging DOI Creative Commons
Yongli Chen, Yanyan Zhang, Kaimin Zhang

et al.

Advanced Therapeutics, Journal Year: 2024, Volume and Issue: 7(12)

Published: Nov. 12, 2024

Abstract Skin aging is characterized by a deterioration of skin quality over time resulting from physiological changes and oxidative stress (OS). Superoxide dismutase (SOD) an effective antioxidant enzyme widely used as food supplement cosmetic additive to alleviate OS retard aging. However, conventional SOD delivery routes commonly yield unsatisfactory results due limited stability, compromised bioavailability, low absorption efficiency in the gastrointestinal (GI) tract. These issues are addressed developing SOD‐encapsulated polymeric microneedle (PMN) patches for efficient transdermal delivery. The use highly stable isolated hot spring microbe ensures its reactivity throughout PMN fabrication application. This vehicle demonstrated excellent effectiveness through inhibiting skin‐aging promoting hair growth validated extensive vivo experiments using D‐galactose (D‐gal) induced aging‐mouse model. SOD‐PMNs promoted regeneration follicles, increased melanin synthesis, decreased lipid oxidation, elevated antioxidative capacity tissue. success promises wide applicability pharmaceutical industries.

Language: Английский

Graphene-Based Polymeric Microneedles for Biomedical Applications: A Comprehensive Review DOI Creative Commons
Somayeh Moradi, Farah ’Atiqah Abdul Azam, Hossein Abdollahi

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Transdermal drug delivery presents a promising noninvasive approach, bypassing first-pass metabolism and gastrointestinal degradation. However, the stratum corneum (SC) barrier limits absorption, necessitating development of effective systems. Microneedles, particularly polymer-based ones, offer solution by penetrating SC while avoiding critical nerves capillaries. These microneedles are biodegradable, nontoxic, easily manufacturable, making them highly attractive platform for transdermal delivery. their clinical application remains limited due to suboptimal therapeutic efficacy slow release rates. Recent advancements have introduced incorporation nanodrugs, such as nanoparticles encapsulated drugs, into enhance efficiency. Among materials explored, graphene its derivatives, including oxide (GO) reduced (rGO), garnered significant attention. Their exceptional mechanical strength, electrical conductivity, antibacterial properties not only improve performance but also rates biocompatibility. This review synthesizes current state microneedle technologies, focusing on materials, fabrication techniques, challenges. It examines potential graphene-based microneedles, comparing traditional in terms efficiency stability. The highlights key challenges, scalability, biocompatibility, complexity, suggests future research directions address these issues. quantum dots (GQDs) is identified avenue improving profiles, stability, real-time tracking diffusion. Finally, outlines emerging applications, smart systems, biosensing, monitoring, urging further exploration unlock full graphene-enhanced settings.

Language: Английский

Citations

3
Biomaterial-based Drug Delivery Strategies for Oral Mucosa DOI
Junhui Liu,

Jiao Sun,

Jun Hu

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 251, P. 114604 - 114604

Published: March 5, 2025

Language: Английский

Citations

0
Transdermal Delivery of Superoxide Dismutase Using Polymeric Microneedle Patches to Inhibit Skin Aging DOI Creative Commons
Yongli Chen, Yanyan Zhang, Kaimin Zhang

et al.

Advanced Therapeutics, Journal Year: 2024, Volume and Issue: 7(12)

Published: Nov. 12, 2024

Abstract Skin aging is characterized by a deterioration of skin quality over time resulting from physiological changes and oxidative stress (OS). Superoxide dismutase (SOD) an effective antioxidant enzyme widely used as food supplement cosmetic additive to alleviate OS retard aging. However, conventional SOD delivery routes commonly yield unsatisfactory results due limited stability, compromised bioavailability, low absorption efficiency in the gastrointestinal (GI) tract. These issues are addressed developing SOD‐encapsulated polymeric microneedle (PMN) patches for efficient transdermal delivery. The use highly stable isolated hot spring microbe ensures its reactivity throughout PMN fabrication application. This vehicle demonstrated excellent effectiveness through inhibiting skin‐aging promoting hair growth validated extensive vivo experiments using D‐galactose (D‐gal) induced aging‐mouse model. SOD‐PMNs promoted regeneration follicles, increased melanin synthesis, decreased lipid oxidation, elevated antioxidative capacity tissue. success promises wide applicability pharmaceutical industries.

Language: Английский

Citations

0