Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 203 - 252
Опубликована: Ноя. 29, 2024
Язык: Английский
Biomaterials, Год журнала: 2025, Номер 318, С. 123138 - 123138
Опубликована: Янв. 28, 2025
Язык: Английский
Процитировано
3
International Journal of Pharmaceutics, Год журнала: 2025, Номер 672, С. 125336 - 125336
Опубликована: Фев. 11, 2025
Язык: Английский
Процитировано
2
Bioengineering & Translational Medicine, Год журнала: 2025, Номер unknown
Опубликована: Фев. 26, 2025
Abstract Gastrointestinal cancers, a major global cause of cancer‐related mortality and disease burden, are heterogeneous group malignant aliments involving different organs the digestive system. The late clinical diagnosis, genomic tumor heterogeneity, high complexity gastrointestinal microenvironment, along with increasing treatment resistance have been recognized as main contributing factors to current inadequacy interventions poor prognosis cancer patients. In coming years, is unfortunately predicted increase due absence early detection effective therapeutic options. Biomembrane‐coated biomimetic nanoparticles (NPs) recently appointed advanced nanotechnological tools for management cancers. These comprise not only cell‐mimicking nanodevices (the pioneers this top‐down coating technology), but also exosome bacterial mimetics. Due their enhanced bio‐interfacing features, biocompatibility, immune evasion, specific targetability tumorous tissues, these nanostructures successfully exploited provide safer, effective, targeted applications. This review highlights latest research on biomembrane‐coated nanosystems therapy diagnosis most common deadliest subtypes namely colorectal cancer, gastric liver esophageal pancreatic cancer. challenges toward translation mentioned.
Язык: Английский
Процитировано
1
Drug Discovery Today, Год журнала: 2024, Номер 29(8), С. 104060 - 104060
Опубликована: Июнь 12, 2024
The application of nanotechnology has significantly advanced the development novel platforms that enhance disease treatment and diagnosis. A key innovation in this field is creation antitoxin nanoparticles (ATNs), designed to address toxin exposure. These precision-engineered nanosystems have unique physicochemical properties selective binding capabilities, allowing them effectively capture neutralize toxins from various biological, chemical, environmental sources. In review, we thoroughly examine their therapeutic diagnostic potential for managing toxin-related challenges. We also explore recent advancements offer critical insights into design clinical implementation ATNs.
Язык: Английский
Процитировано
4
Biochemical Pharmacology, Год журнала: 2024, Номер 229, С. 116523 - 116523
Опубликована: Сен. 7, 2024
Язык: Английский
Процитировано
3
Materials Today Chemistry, Год журнала: 2025, Номер 43, С. 102506 - 102506
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Journal of Controlled Release, Год журнала: 2025, Номер 379, С. 537 - 548
Опубликована: Янв. 24, 2025
Язык: Английский
Процитировано
0
Biomimetics, Год журнала: 2025, Номер 10(3), С. 141 - 141
Опубликована: Фев. 25, 2025
Cardiomyopathies, a cause of heart failure, are predominant death globally and may lead to discernible myocardial abnormalities. Several therapeutic agents were discovered, developed, investigated, evaluated save patients’ lives improve their quality life. The effective administration drugs improves outcomes while reducing side effects. Nanoparticles (NPs) have been utilised for the delivery demonstrate promise in ischaemia/reperfusion injury. However, significant limitations NPs include non-specific targeting immunogenicity. To cardiac biocompatibility, surface modifications using cell membrane (cCM) coating on hypothesised. Here, cCMs isolated from human ventricular line (AC16), mesoporous silica nanoparticles (MSNs) synthesised then coated with cCMs. membrane-coated (cCMCMSNs) did not significantly alter encapsulation efficiency or release profile loaded drug (Rhodamine B) comparison MSN. Moreover, cCMCMSNs demonstrated enhanced distribution RhB specifically cells, compared other types, without causing cytotoxicity. evaluate immune escape, exposed activated macrophages, demonstrating that phagocytosed lesser extent than This study synthesis membranes as nanomedicine technologies enhance selective potentially offering an alternate method cardiovascular diseases.
Язык: Английский
Процитировано
0
Bioengineering, Год журнала: 2025, Номер 12(4), С. 362 - 362
Опубликована: Март 31, 2025
Active targeting nanoparticles are a new generation of drug and gene delivery systems with the potential for greatly improved therapeutics compared to conventional nanomedicine approaches. Despite their potential, translation active faces challenges in production scale-up batch consistency. Accurate quality control methods nanoparticle therapeutic payload coating characterization critical attaining desired levels repeatability, drug/gene loading efficiency, molecule effectiveness, safety profiles. Current limitations technologies, such as relying on ensemble-average analysis, pose assessing content surface modification heterogeneity, which can affect outcomes. Single-molecule analysis technologies have emerged promising alternative, offering rich information heterogeneity stochastic variations between batches. This review first evaluates identifies traditional tools that rely indirect, bulk solution quantification methods. Subsequently, newly emerging introduced targeted moiety efficiencies single-nanoparticle resolution, help guide researchers towards advancing into clinical setting.
Язык: Английский
Процитировано
0
Journal of Functional Biomaterials, Год журнала: 2025, Номер 16(4), С. 148 - 148
Опубликована: Апрель 21, 2025
Current primary liver cancer therapies, including sorafenib and transarterial chemoembolization, face significant limitations due to chemoresistance caused by impaired drug uptake, altered metabolism, other genetic modulations. These challenges contribute relapse rates of 50–80% within five years. The need for improved treatment strategies (adjuvant therapy, unsatisfactory enhanced permeability retention (EPR) effect) has driven research into advanced delivery systems, targeted nanoparticles, biomaterials, combinatory approaches. Therefore, this review evaluates recent advancements in pharmacotherapy, focusing on the potential systems its derivatives. Approaches such as leveraging Kupffer cells tumor migration or utilizing smaller NPs inter-/intracellular delivery, address EPR limitations. Biomaterials therapies targeting have demonstrated effectiveness increasing tumor-specific but clinical evidence remains limited. Combination emerged an interesting solution overcoming broadening therapeutic functionality. Biomimetic employing blood exosomes, provide methods tumors, preventing metastasis, strengthening immune responses. However, differences between preclinical models human physiology remain a barrier translating these findings success. Future must focus development adjuvant therapy refining overcome heterogeneity low accumulation.
Язык: Английский
Процитировано
0