Angewandte Chemie International Edition,
Год журнала:
2022,
Номер
61(29)
Опубликована: Май 12, 2022
The
asymmetric
catalytic
addition
of
linear
Grignard
reagents
to
ketones
has
been
a
long-standing
challenge
in
organic
synthesis.
Herein,
novel
family
PNP
ligands
(W-Phos)
was
designed
and
applied
copper-catalyzed
aryl
alkyl
ketones,
allowing
facile
access
versatile
chiral
tertiary
alcohols
good
high
yields
with
excellent
enantioselectivities
(up
94
%
yield,
96
ee).
process
can
also
be
used
synthesize
allylic
from
more
challenging
α,β-unsaturated
ketones.
Notably,
the
potential
utility
this
method
is
demonstrated
gram-scale
synthesis
modification
various
densely
functionalized
medicinally
relevant
molecules.
Chemical Science,
Год журнала:
2020,
Номер
11(24), С. 6283 - 6288
Опубликована: Янв. 1, 2020
A
highly
chemo-,
regio-,
enantio-selectivitive
Pd/Xiang-Phos-catalyzed
intermolecular
carboheterofunctionalization
of
2,3-dihydrofurans
for
the
synthesis
polysubstituted
benzofused
heterocycles
mild
conditions.
Angewandte Chemie,
Год журнала:
2018,
Номер
130(37), С. 12243 - 12246
Опубликована: Июль 19, 2018
Abstract
Unprecedented
enantioselective
intramolecular
Heck
carbonylation
reactions
of
arenediazonium
salts
were
enabled
by
a
chiral
N,N
ligand.
This
reaction
constitutes
the
first
that
proceeds
through
migratory
insertion
followed
CO
insertion.
The
enantioenriched
functionalized
dihydrobenzofurans
obtained
in
good
to
high
yields
and
enantiomeric
ratios
up
98:2
under
mild
operationally
simple
conditions.
Angewandte Chemie International Edition,
Год журнала:
2020,
Номер
59(27), С. 10814 - 10818
Опубликована: Март 26, 2020
Conformationally
restricted
azabicycles
are
becoming
increasingly
important
in
medicinal
research.
Asymmetric
Heck
bicyclization
of
enynes
proceeds
to
give
medicinally
useful
aza[3.1.0]
and
aza[4.1.0]
bicycles
with
excellent
enantioselectivity.
The
key
organopalladium
species
after
can
be
trapped
by
silanes
terminal
alkynes.
Angewandte Chemie,
Год журнала:
2019,
Номер
132(7), С. 2791 - 2797
Опубликована: Ноя. 22, 2019
Abstract
Sonogashira‐type
cross‐couplings
are
one
of
the
most
significant
alkynylations
in
organic
chemistry.
One
first
palladium‐catalyzed
intramolecular
Heck/Sonogashira
reactions
alkenes
with
terminal
alkynes
is
now
reported.
With
this
method,
a
variety
uniquely
substituted
chiral
benzene‐fused
heterocycles
bearing
propargyl‐substituted
all‐carbon
quaternary
stereocenter
were
obtained
straightforward,
high‐yielding,
and
highly
stereoselective
manner
under
mild
conditions.
Salient
features
process
include
use
readily
available
substrates,
high
selectivities,
broad
substrate
scope
as
well
versatile
product
functionalizations.
Angewandte Chemie International Edition,
Год журнала:
2022,
Номер
61(29)
Опубликована: Май 12, 2022
The
asymmetric
catalytic
addition
of
linear
Grignard
reagents
to
ketones
has
been
a
long-standing
challenge
in
organic
synthesis.
Herein,
novel
family
PNP
ligands
(W-Phos)
was
designed
and
applied
copper-catalyzed
aryl
alkyl
ketones,
allowing
facile
access
versatile
chiral
tertiary
alcohols
good
high
yields
with
excellent
enantioselectivities
(up
94
%
yield,
96
ee).
process
can
also
be
used
synthesize
allylic
from
more
challenging
α,β-unsaturated
ketones.
Notably,
the
potential
utility
this
method
is
demonstrated
gram-scale
synthesis
modification
various
densely
functionalized
medicinally
relevant
molecules.
