Angewandte Chemie,
Journal Year:
2019,
Volume and Issue:
132(7), P. 2791 - 2797
Published: Nov. 22, 2019
Abstract
Sonogashira‐type
cross‐couplings
are
one
of
the
most
significant
alkynylations
in
organic
chemistry.
One
first
palladium‐catalyzed
intramolecular
Heck/Sonogashira
reactions
alkenes
with
terminal
alkynes
is
now
reported.
With
this
method,
a
variety
uniquely
substituted
chiral
benzene‐fused
heterocycles
bearing
propargyl‐substituted
all‐carbon
quaternary
stereocenter
were
obtained
straightforward,
high‐yielding,
and
highly
stereoselective
manner
under
mild
conditions.
Salient
features
process
include
use
readily
available
substrates,
high
selectivities,
broad
substrate
scope
as
well
versatile
product
functionalizations.
Chemical Science,
Journal Year:
2020,
Volume and Issue:
11(24), P. 6283 - 6288
Published: Jan. 1, 2020
A
highly
chemo-,
regio-,
enantio-selectivitive
Pd/Xiang-Phos-catalyzed
intermolecular
carboheterofunctionalization
of
2,3-dihydrofurans
for
the
synthesis
polysubstituted
benzofused
heterocycles
mild
conditions.
Chemistry - An Asian Journal,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 22, 2025
Abstract
Traditionally,
the
discovery
of
ligands
for
organic
reactions
has
relied
heavily
on
intuition
and
experience
chemists,
leading
to
a
trial‐and‐error
process
that
is
both
time‐consuming
inherently
biased.
The
rise
data
science
now
offers
more
systematic
efficient
approach
exploring
chemical
spaces,
moving
beyond
heuristic
constraints
conventional
ligand
design
enabling
data‐driven,
predictive
method.
In
this
study,
we
introduce
“SadPhos
Library”,
comprehensive
collection
890
reported
chiral
sulfinamide
phosphine
ligands,
use
physical
descriptors
systematically
map
their
space.
By
examining
small
dataset
known
active
demonstrate
how
SadPhos
library
can
help
identify
key
properties
associated
with
performance
thus
streamline
optimization.
Furthermore,
employing
dimensionality
reduction
clustering
techniques,
pinpoint
representative
subset
facilitates
targeted
exploration
diverse
landscape.
Angewandte Chemie,
Journal Year:
2018,
Volume and Issue:
130(37), P. 12243 - 12246
Published: July 19, 2018
Abstract
Unprecedented
enantioselective
intramolecular
Heck
carbonylation
reactions
of
arenediazonium
salts
were
enabled
by
a
chiral
N,N
ligand.
This
reaction
constitutes
the
first
that
proceeds
through
migratory
insertion
followed
CO
insertion.
The
enantioenriched
functionalized
dihydrobenzofurans
obtained
in
good
to
high
yields
and
enantiomeric
ratios
up
98:2
under
mild
operationally
simple
conditions.
Angewandte Chemie International Edition,
Journal Year:
2020,
Volume and Issue:
59(27), P. 10814 - 10818
Published: March 26, 2020
Conformationally
restricted
azabicycles
are
becoming
increasingly
important
in
medicinal
research.
Asymmetric
Heck
bicyclization
of
enynes
proceeds
to
give
medicinally
useful
aza[3.1.0]
and
aza[4.1.0]
bicycles
with
excellent
enantioselectivity.
The
key
organopalladium
species
after
can
be
trapped
by
silanes
terminal
alkynes.
Angewandte Chemie,
Journal Year:
2019,
Volume and Issue:
132(7), P. 2791 - 2797
Published: Nov. 22, 2019
Abstract
Sonogashira‐type
cross‐couplings
are
one
of
the
most
significant
alkynylations
in
organic
chemistry.
One
first
palladium‐catalyzed
intramolecular
Heck/Sonogashira
reactions
alkenes
with
terminal
alkynes
is
now
reported.
With
this
method,
a
variety
uniquely
substituted
chiral
benzene‐fused
heterocycles
bearing
propargyl‐substituted
all‐carbon
quaternary
stereocenter
were
obtained
straightforward,
high‐yielding,
and
highly
stereoselective
manner
under
mild
conditions.
Salient
features
process
include
use
readily
available
substrates,
high
selectivities,
broad
substrate
scope
as
well
versatile
product
functionalizations.
