ACS Pharmacology & Translational Science,
Год журнала:
2023,
Номер
6(12), С. 1958 - 1971
Опубликована: Ноя. 22, 2023
Onychomycosis
caused
by,
e.g.,
Trichophyton
rubrum
or
Candida
albicans
is
the
most
common
human
nail
disease
with
a
worldwide
prevalence
of
more
than
10%.
The
therapeutic
efficacy
topical
antimycotics
for
treatment
onychomycosis
proved
to
be
inadequate
in
numerous
studies
on
patients.
main
reasons
are,
above
all,
poor
bioavailability
active
ingredients
compartment,
causing
requirement
extremely
long
application
periods
and
correspondingly
high
demands
adherence
by
patient.
In
present
study,
we
aimed
develop
effective
prompt
photodynamic
approach
onychomycosis.
principle
therapy
(PDT)
has
already
been
investigated.
However,
these
used
photosensitizers
such
as
methylene
blue,
which
were
neither
optimized
their
keratinophilic
features
nor
nail.
Hence,
initiated
screening
campaign
using
T.
C.
cell-based
assays,
infected
bovine
keratin
models,
keratin-penetrating
irradiation
identify
suitable
hit
compounds
PDT
toward
Here,
report
discovery
Henna/Lawson-derived
naphthazarines
that
act
highly
potent
antimycotic
photoresponsiveness
when
irradiated
light
at
keratin-permeable
wavelength
(>500
nm,
10
11
PDT-IC50
=
1
3
nM,
respectively,
against
rubrum),
hence
superior
positive
controls
nystatin
clotrimazole.
Notably,
our
not
only
affected
actual
pathogens
but
also
prevented
reinfection
models
within
days,
suggesting
an
additional
fungal
spores.
Compared
established
concepts,
proposed
novel
naphthazarine
could
enable
effective,
precise,
sustainable
option
future
Journal of the American Chemical Society,
Год журнала:
2024,
Номер
146(26), С. 18002 - 18010
Опубликована: Июнь 21, 2024
Imidazoles
are
crucial
structural
components
in
a
variety
of
small-molecule
inhibitors
designed
to
target
different
kinases
anticancer
treatment.
However,
the
effectiveness
such
is
often
hampered
by
nonspecific
effects
and
development
resistance.
Photopharmacology
provides
compelling
solution
enabling
external
control
over
drug
activity
with
spatiotemporal
precision.
Herein,
we
introduce
novel
strategy
for
caging
bioactive
triarylimidazole-based
molecules.
This
approach
involves
introducing
dialkylamino
group
as
photoremovable
on
carbon
atom
imidazole
ring,
which
intrinsically
modulates
core
structure
from
planar
tetrahedral
2H-imidazole,
caged
compound
be
selectively
uncaged
upon
visible
light
exposure.
We
applied
this
innovative
technique
SB431542,
inhibitor
that
targets
pivotal
TGF-β
signaling
pathway,
dysregulation
linked
several
human
diseases,
including
cancer.
Our
results
demonstrated
selective
inhibition
breast
cancer
cell
migration
vitro
activation,
highlighting
potential
our
transform
molecules
into
light–activatable
drugs,
thereby
facilitating
regulation
their
pharmacological
activity.
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
72(22), С. 12469 - 12477
Опубликована: Май 21, 2024
Photopharmacology
can
be
implemented
in
a
way
of
regulating
drug
activities
by
light-controlling
the
molecular
configuations.
Three
photochromic
ligands
(PCLs)
that
bind
on
one
or
two
sites
GABARs
and
nAChRs
were
reported
here.
These
multiphoton
PCLs,
including
FIP-AB-FIP,
IMI-AB-FIP,
IMI-AB-IMI,
are
constructed
with
an
azobenzene
(AB)
bridge
covalently
connects
fipronil
(FIP)
imidacloprid
(IMI)
molecules.
Interestingly,
three
PCLs
as
well
FIP
IMI
showed
great
insecticidal
against
Nanoscale,
Год журнала:
2024,
Номер
16(41), С. 19254 - 19265
Опубликована: Янв. 1, 2024
Multifunctional
colloidal
microgels
that
exhibit
stimuli-responsive
behaviour
and
excellent
biocompatibility
have
attracted
particular
attention
for
developing
functional
compartmentalized
networks.
Herein,
a
series
of
(M0,
M1,
M2)
were
designed
through
the
copolymerization
di(ethylene
glycol)
methyl
ether
methacrylate
(DEGMA)
methacrylic
acid
(MAA)
monomers
using
hydroxy
ethyl
methacrylate-coupled
azobenzene
(HEMA-Az)
ethylene
glycol
dimetharylate
(EGDMA)
as
crosslinkers.
The
in
response
to
temperature,
pH,
light
was
thoroughly
investigated
spectroscopic,
microscopic,
light-scattering
techniques.
Interestingly,
deswelled
with
an
increase
decrease
under
irradiation
UV
light.
Such
reversible
swelling/deswelling
exploited
microgel
M2,
which
showed
better
photoactuation
at
pH
5
higher
fluid
pumping
velocity.
actuating
M2
optimized
loading
drug
ciprofloxacin
(Cf)
study
its
release
different
conditions.
Microgel
exhibited
photoresponsive
Cf
37
°C,
demonstrating
potential
application
on-demand
release.
Photochemistry and Photobiology,
Год журнала:
2024,
Номер
100(4), С. 1151 - 1153
Опубликована: Апрель 25, 2024
Abstract
This
perspective
article
features
the
recent
work
published
in
this
journal
on
functionalized
azobenzene
photoswitches,
studied
by
Venkataramani
and
coworkers
[Grewal,
S.
et
al
(2024)
Photochem.
Photobiol.
,
1–16].
Azobenzene‐based
photochromic
molecules
undergo
reversible
trans
‐to‐
cis
isomerization
under
exposure
to
light.
The
reverse
also
takes
place
thermal
conditions
dark.
study
explores
how
different
functional
groups
at
various
positions
affect
responses
of
these
compounds
light,
their
stabilities,
isomeric
ratios
photostationary
states,
supramolecular
behavior.
Results
show
varied
half‐lives,
influenced
terminal
positions.
Aggregation
studies
reveal
formation
architectures,
from
microcrystals
gels
with
systems.
Despite
complexities
large
volume
30
compounds,
research
provides
insights
into
designing
efficient
motifs.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(15), С. 10939 - 10945
Опубликована: Июль 22, 2024
Dibenzotriazonine
represent
a
new
class
of
nine-membered
cyclic
azobenzenes
with
nitrogen
atom
embedded
in
the
bridging
chain.
To
enable
future
applications
this
photoactive
backbone,
we
propose
study
synthesis
mono-
and
dihalogenated
triazonines,
that
allow
late-stage
introduction
different
functionalized
aryl
groups
heteroatoms
(N,
O,
P)
via
palladium-catalyzed
reactions.
Indeed,
diphenylphosphoryl-triazonines
were
synthesized
functional
such
as
aniline
or
phenol.
Bis(diphenylphosphoryl)phenyl
bis-carbamate-triazonines
also
isolated
good
yields.
