Capsaicin from chili peppers and its analogues and their valued applications: An updated literature review
Food Research International,
Год журнала:
2025,
Номер
208, С. 116034 - 116034
Опубликована: Фев. 25, 2025
Язык: Английский
Discovery of new 1,2,3,4-tetrahydro-β-carboline derivatives decorated with 3-N-substituted propionyl moiety flexibly bridged-chain as reactive oxygen species inducer for efficient antibacterial treatment
Bioorganic Chemistry,
Год журнала:
2025,
Номер
160, С. 108473 - 108473
Опубликована: Апрель 14, 2025
Язык: Английский
Discovery of novel seven-membered ring derivatives of ONC212 as caseinolytic protease P protein activators using the ring expansion strategy: Rational design, synthesis, and antibacterial evaluation
X. FU,
Yu Peng,
Zhou‐Qing Long
и другие.
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 141866 - 141866
Опубликована: Март 1, 2025
Язык: Английский
DSF‐inspired discovery of novel zingerone‐based quorum‐sensing inhibitors: an attractive tactic of fighting Xanthomonas bacterial infections
Pest Management Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 26, 2025
Plant
bacterial
diseases
have
precipitated
a
global
crisis
in
human
health
and
food
security.
In
agriculture,
such
as
the
rice
white-leaf
blight
can
cause
considerable
reduction
crop
yields
and,
extreme
cases,
complete
failure.
Therefore,
there
is
an
urgent
need
for
novel
green
pesticides
with
innovative
modes-of-action
(MoAs).
A
series
of
zingerone
derivatives
isopropanolamine
skeleton
were
designed
their
quorum-sensing
effects
estimated
using
biomimetic
strategies.
The
results
showed
that
compound
A12
effectively
inhibits
growth
Xanthomonas
oryzae
pv.
[Xoo,
median
effective
concentration
(EC50)
=
3.55
μg
mL-1],
axonopodis
citri
(Xac,
EC50
3.23
mL-1)
oryzicola
(Xoc,
7.48
mL-1).
Molecular
docking
revealed
forms
multiple
interactions
RpfF
protein,
while
fluorescence
titration
experiments
further
verified
interaction
between
them.
Additionally,
was
found
to
inhibit
Xoo
biofilm
formation,
extracellular
polysaccharide
production
other
virulence
factors.
vivo
pot
exhibited
excellent
curative
(53.59%)
protective
(57.65%)
activity
against
Xoo.
conclusion,
A12's
primary
MoA
achieved
by
affecting
formation
biofilms
expression
various
factors,
including
related
genes.
summary,
this
study
highlights
displays
notable
sensing
activity.
advancement
inhibitors
through
strategies
offers
promising
avenues
future
research.
©
2025
Society
Chemical
Industry.
Язык: Английский
Polystyrene-microplastics and Emamectin Benzoate co-exposure induced lipid remodeling by suppressing PPARα signals to drive ACSL4-dependent ferroptosis and carp splenic injury
Hao Wu,
Tong Xu,
Naixi Yang
и другие.
Pesticide Biochemistry and Physiology,
Год журнала:
2025,
Номер
unknown, С. 106396 - 106396
Опубликована: Март 1, 2025
Язык: Английский
Recent advances in photopharmacology: Harnessing visible light‐activated azobenzene photoswitches
Deleted Journal,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 25, 2025
Abstract
In
the
era
of
precision
medicine,
photopharmacology
that
employs
molecular
photoswitches
offers
unique
opportunities
to
control
action
bioactive
molecules
with
high
spatiotemporal
resolution,
while
reducing
drug
side
effects,
systemic
toxicity
and
emergence
resistance.
Over
past
two
decades,
field
has
witnessed
great
achievements
in
treating
blindness,
cancer,
diabetes,
antibiotic
resistance,
name
but
a
few.
Several
challenges
remain,
however,
particular
fact
most
photopharmacological
agents
trigger
their
activity
by
Ultraviolet
light,
which
is
damaging
normal
cells
poor
tissue
permeability.
Visible
light‐activated
are
hence
highly
desirable
have
captured
keen
recent
research
interest.
This
review
highlights
strategies
for
synthesis
visible
light‐responsive
azobenzenes
(ABs)
applications
emerging
photopharmacology.
Such
photoswitchable
drugs
tremendously
extend
scope
future
vivo
applications.
Furthermore,
we
identify
current
discuss
rational
design
switches
at
higher
wavelength.
We
hope
inspire
further
into
photochemistry
novel
based
on
ABs
or
other
photoswitches,
triggered
excitation
light
“phototherapeutic
window”
650–900
nm,
ultimately
enabling
full
realization
these
“smart”
clinical
practice.
Язык: Английский
The Intricate Nonribosomal Assembly of a Potent Antifungal Lipopeptide from the Burkholderia cepacia Complex
Journal of the American Chemical Society,
Год журнала:
2025,
Номер
unknown
Опубликована: Июнь 2, 2025
The
Burkholderia
cepacia
complex
(BCC)
is
a
group
of
Gram-negative
bacteria
known
for
their
pathogenicity
to
patients
suffering
from
cystic
fibrosis
(CF).
BCC-belonging
strain
B.
pyrrocinia
BC11
(formerly
BC11)
produces
AFC-BC11,
compound
with
strong
activity
against
phytopathogenic
fungi.
In
this
contribution,
we
report
on
the
unprecedented
N-acyl-tetrapeptide
structure
and
antifungal
potency
natural
product.
We
further
provide
insights
into
central
steps
its
biosynthesis
mediated
by
nonclassical
nonribosomal
peptide
synthesis
machinery
lacking
condensation
domains.
With
involvement
sole
acyl/peptidyl
carrier
protein
AfcK,
an
acyltransferase
AfcL
coenzyme
A,
growing
acyl-peptide
chain
shuffled
between
different
thioester
carriers
during
intricate
biosynthetic
assembly.
knowledge
AFC-BC11
may
contribute
development
antifungals
phytopathogens
and,
afc
gene
cluster
being
conserved
in
various
strains,
possibly
understanding
human
pathogenesis
BCC.
Язык: Английский