Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(15), С. 3710 - 3718
Опубликована: Янв. 1, 2024
Meeting
the
demand
for
efficient
photosensitizers
in
photodynamic
therapy
(PDT),
a
series
of
iridium(III)
complexes
decorated
with
silicane-modified
rhodamine
(Si-rhodamine)
was
meticulously
designed
and
synthesized.
These
demonstrate
exceptional
PDT
potential
owing
to
their
strong
absorption
near-infrared
(NIR)
spectrum,
particularly
responsive
808
nm
laser
stimulation.
This
feature
is
pivotal,
enabling
deep-penetration
excitation
overcoming
depth-related
challenges
clinical
applications.
The
molecular
structures
these
allow
reliable
tuning
singlet
oxygen
generation
NIR
excitation,
through
modification
cyclometalating
ligand.
Notably,
one
(4)
exhibits
remarkable
ROS
quantum
yield
0.69.
Chemical Reviews,
Год журнала:
2021,
Номер
121(21), С. 13454 - 13619
Опубликована: Сен. 28, 2021
This
review
presents
a
robust
strategy
to
design
photosensitizers
(PSs)
for
various
species.
Photodynamic
therapy
(PDT)
is
photochemical-based
treatment
approach
that
involves
the
use
of
light
combined
with
light-activated
chemical,
referred
as
PS.
Attractively,
PDT
one
alternatives
conventional
cancer
due
its
noninvasive
nature,
high
cure
rates,
and
low
side
effects.
PSs
play
an
important
factor
in
photoinduced
reactive
oxygen
species
(ROS)
generation.
Although
concept
photosensitizer-based
photodynamic
has
been
widely
adopted
clinical
trials
bioimaging,
until
now,
our
surprise,
there
no
relevant
article
on
rational
designs
organic
PDT.
Furthermore,
most
published
articles
focused
nanomaterials
nanotechnology
based
traditional
PSs.
Therefore,
this
aimed
at
reporting
recent
strategies
develop
innovative
enhanced
therapy,
each
example
described
detail
instead
providing
only
general
overview,
typically
done
previous
reviews
PDT,
provide
intuitive,
vivid,
specific
insights
readers.
Chemical Reviews,
Год журнала:
2020,
Номер
120(24), С. 13135 - 13272
Опубликована: Окт. 30, 2020
Photoactivatable
(alternatively,
photoremovable,
photoreleasable,
or
photocleavable)
protecting
groups
(PPGs),
also
known
as
caged
photocaged
compounds,
are
used
to
enable
non-invasive
spatiotemporal
photochemical
control
over
the
release
of
species
interest.
Recent
years
have
seen
development
PPGs
activatable
by
biologically
and
chemically
benign
visible
near-infrared
(NIR)
light.
These
long-wavelength-absorbing
moieties
expand
applicability
this
powerful
method
its
accessibility
non-specialist
users.
This
review
comprehensively
covers
organic
transition
metal-containing
photoactivatable
compounds
(complexes)
that
absorb
in
visible-
NIR-range
various
leaving
gasotransmitters
(carbon
monoxide,
nitric
oxide,
hydrogen
sulfide).
The
text
NIR-light-induced
photosensitized
using
molecular
sensitizers,
quantum
dots,
upconversion
second-harmonic
nanoparticles,
well
via
photodynamic
(photooxygenation
singlet
oxygen)
photothermal
effects.
Release
from
polymers,
micelles,
vesicles,
photoswitches,
along
with
related
emerging
field
photopharmacology,
is
discussed
at
end
review.
Chemical Science,
Год журнала:
2022,
Номер
13(18), С. 5085 - 5106
Опубликована: Янв. 1, 2022
This
minireview
summarizes
recent
developments
of
noble
metal
photosensitizers
based
on
Ru,
Ir,
and
Pt.
Molecular
design
strategies
to
overcome
shallow
tissue
penetration
depth,
O
2
-dependence
the
limited
therapeutic
effect
are
introduced.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(23)
Опубликована: Апрель 5, 2024
Abstract
Reactive
oxygen
species
(ROS)
have
become
an
effective
tool
for
tumor
treatment.
The
combination
of
photodynamic
therapy
(PDT)
and
chemodynamic
(CDT)
takes
advantage
various
ROS
enhances
therapeutic
effects.
However,
the
activation
CDT
usually
occurs
before
PDT,
which
hinders
sustained
maintenance
hydroxyl
radicals
(⋅OH)
reduces
treatment
efficiency.
Herein,
we
present
a
light‐triggered
nano‐system
based
on
molecular
aggregation
regulation
converting
cancer
from
PDT/photothermal
(PTT)
to
long‐lasting
CDT.
ordered
J‐aggregation
properties
cyanine
moiety
while
simultaneously
suppressing
capabilities
copper‐porphyrin
moiety.
Upon
light
irradiation,
Cu‐PCy
JNPs
demonstrate
strong
photothermal
Meanwhile,
triggers
rapid
degradation
backbone,
leading
destruction
J‐aggregation.
As
result,
is
sequentially
activated,
generation
⋅OH
observed
up
48
hours,
causing
potent
cellular
oxidative
stress
apoptosis.
Due
their
excellent
accumulation,
exhibit
in
vivo
ablation
through
therapy.
This
work
provides
new
approach
effectively
prolonging
activity
ROS‐based
Accounts of Chemical Research,
Год журнала:
2018,
Номер
51(12), С. 3226 - 3235
Опубликована: Ноя. 12, 2018
ConspectusOptical
approaches
that
visualize
and
manipulate
biological
processes
have
transformed
modern
biomedical
research.
An
enduring
challenge
is
to
translate
these
powerful
methods
into
increasingly
complex
physiological
settings.
Longer
wavelengths,
typically
in
the
near-infrared
(NIR)
range
(∼650–900
nm),
can
enable
advances
both
fundamental
clinical
settings;
however,
suitable
probe
molecules
are
needed.
The
pentamethine
heptamethine
cyanines,
led
by
prototypes
Cy5
Cy7,
among
most
useful
compounds
for
fluorescence-based
applications,
finding
broad
use
a
of
contexts.
defining
chemical
feature
molecules,
key
chromophoric
element,
an
odd-numbered
polymethine
links
two
nitrogen
atoms.
Not
only
light-harvesting
functional
group,
cyanine
chromophore
subject
thermal
photochemical
reactions
dramatically
alter
many
properties
molecules.This
Account
describes
our
recent
studies
define
intrinsic
reactivity.
hypothesis
driving
this
research
novel
chemistries
be
used
address
challenging
problems
areas
imaging
drug
delivery.
We
first
review
reaction
discovery
efforts
seek
limitations
long-wavelength
fluorophores:
undesired
thiol
reactivity
modest
fluorescence
quantum
yield.
Heptamethine
cyanines
with
O-alkyl
substituent
at
central
C4′
carbon
were
prepared
through
N-
O-transposition
reaction.
Unlike
commonly
C4′-phenol
variants,
new
class
fluorophores
resistant
modification
exhibits
improved
vivo
when
as
antibody
tags.
also
developed
strategy
enhance
yield
far-red
cyanines.
Using
synthetic
involving
cross
metathesis/tetracyclization
sequence,
approach
conformationally
restrains
scaffold.
resulting
exhibit
enhanced
(ΦF
=
0.69
vs
ΦF
0.15).
Furthermore,
conformational
restraint
improves
interconversion
between
reduced
hydrocyanine
intact
forms,
which
enables
super
resolution
microscopy.This
then
highlights
NIR
photocaging.
Our
involves
deliberate
photooxidation,
previously
associated
photodegradation.
uncaging
sequence
initiated
photooxidative
cleavage
(using
wavelengths
up
780
prompts
C–N
bond
hydrolysis/cyclization
phenol
liberation.
This
has
been
applied
generate
NIR-activated
antibody-drug
conjugates.
Tumor
uptake
monitored
using
fluorescence,
prior
external
irradiation
source.
slow
tumor
progression
increase
survival
MDA-MB-468-luc
mouse
model.
Broadly,
vantage
point
providing
auspicious
features
delivery
