Iridium(iii) complexes decorated with silicane-modified rhodamine: near-infrared light-initiated photosensitizers for efficient deep-tissue penetration photodynamic therapy DOI
Jiqiang Liu, Xing Yang,

Siye Wu

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(15), P. 3710 - 3718

Published: Jan. 1, 2024

Meeting the demand for efficient photosensitizers in photodynamic therapy (PDT), a series of iridium(III) complexes decorated with silicane-modified rhodamine (Si-rhodamine) was meticulously designed and synthesized. These demonstrate exceptional PDT potential owing to their strong absorption near-infrared (NIR) spectrum, particularly responsive 808 nm laser stimulation. This feature is pivotal, enabling deep-penetration excitation overcoming depth-related challenges clinical applications. The molecular structures these allow reliable tuning singlet oxygen generation NIR excitation, through modification cyclometalating ligand. Notably, one (4) exhibits remarkable ROS quantum yield 0.69.

Language: Английский

Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy DOI
Thanh Chung Pham, Nguyễn Văn Nghĩa,

Yeonghwan Choi

et al.

Chemical Reviews, Journal Year: 2021, Volume and Issue: 121(21), P. 13454 - 13619

Published: Sept. 28, 2021

This review presents a robust strategy to design photosensitizers (PSs) for various species. Photodynamic therapy (PDT) is photochemical-based treatment approach that involves the use of light combined with light-activated chemical, referred as PS. Attractively, PDT one alternatives conventional cancer due its noninvasive nature, high cure rates, and low side effects. PSs play an important factor in photoinduced reactive oxygen species (ROS) generation. Although concept photosensitizer-based photodynamic has been widely adopted clinical trials bioimaging, until now, our surprise, there no relevant article on rational designs organic PDT. Furthermore, most published articles focused nanomaterials nanotechnology based traditional PSs. Therefore, this aimed at reporting recent strategies develop innovative enhanced therapy, each example described detail instead providing only general overview, typically done previous reviews PDT, provide intuitive, vivid, specific insights readers.

Language: Английский

Citations

1157
Visible-to-NIR-Light Activated Release: From Small Molecules to Nanomaterials DOI Creative Commons
Roy Weinstain, Tomáš Slanina, Dnyaneshwar Kand

et al.

Chemical Reviews, Journal Year: 2020, Volume and Issue: 120(24), P. 13135 - 13272

Published: Oct. 30, 2020

Photoactivatable (alternatively, photoremovable, photoreleasable, or photocleavable) protecting groups (PPGs), also known as caged photocaged compounds, are used to enable non-invasive spatiotemporal photochemical control over the release of species interest. Recent years have seen development PPGs activatable by biologically and chemically benign visible near-infrared (NIR) light. These long-wavelength-absorbing moieties expand applicability this powerful method its accessibility non-specialist users. This review comprehensively covers organic transition metal-containing photoactivatable compounds (complexes) that absorb in visible- NIR-range various leaving gasotransmitters (carbon monoxide, nitric oxide, hydrogen sulfide). The text NIR-light-induced photosensitized using molecular sensitizers, quantum dots, upconversion second-harmonic nanoparticles, well via photodynamic (photooxygenation singlet oxygen) photothermal effects. Release from polymers, micelles, vesicles, photoswitches, along with related emerging field photopharmacology, is discussed at end review.

Language: Английский

Citations

447
Near Infrared (NIR) absorbing dyes as promising photosensitizer for photo dynamic therapy DOI

Chinna Ayya Swamy P,

Gandhi Sivaraman,

Ragam N. Priyanka

et al.

Coordination Chemistry Reviews, Journal Year: 2020, Volume and Issue: 411, P. 213233 - 213233

Published: March 2, 2020

Language: Английский

Citations

255
Recent progress on molecularly near-infrared fluorescent probes for chemotherapy and phototherapy DOI
Chenxu Yan, Yutao Zhang,

Zhiqian Guo

et al.

Coordination Chemistry Reviews, Journal Year: 2020, Volume and Issue: 427, P. 213556 - 213556

Published: Sept. 16, 2020

Language: Английский

Citations

146
Taking phototherapeutics from concept to clinical launch DOI Open Access
Brianna M. Vickerman, Emilia M. Zywot, Teresa K. Tarrant

et al.

Nature Reviews Chemistry, Journal Year: 2021, Volume and Issue: 5(11), P. 816 - 834

Published: Oct. 6, 2021

Language: Английский

Citations

127
Recent advances in noble metal complex based photodynamic therapy DOI Creative Commons
Yanping Wu,

Shumeng Li,

Yuncong Chen

et al.

Chemical Science, Journal Year: 2022, Volume and Issue: 13(18), P. 5085 - 5106

Published: Jan. 1, 2022

This minireview summarizes recent developments of noble metal photosensitizers based on Ru, Ir, and Pt. Molecular design strategies to overcome shallow tissue penetration depth, O 2 -dependence the limited therapeutic effect are introduced.

Language: Английский

Citations

124
Bioorthogonal chemistry for prodrug activation in vivo DOI
Qunfeng Fu, Siyong Shen, Pengwei Sun

et al.

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(22), P. 7737 - 7772

Published: Jan. 1, 2023

Bioorthogonal chemistry used in prodrug activation for cancer treatment and its potential clinical translation.

Language: Английский

Citations

46
Recent advances in the design and applications of near-infrared II responsive small molecule phototherapeutic agents DOI
Dandan Ma, Hui Bian,

Mingrui Gu

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 505, P. 215677 - 215677

Published: Jan. 31, 2024

Language: Английский

Citations

40
A Light‐Triggered J‐Aggregation‐Regulated Therapy Conversion: from Photodynamic/Photothermal Therapy to Long‐Lasting Chemodynamic Therapy for Effective Tumor Ablation DOI

Kai Wei,

Yanxin Wu,

Xian Zheng

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(23)

Published: April 5, 2024

Abstract Reactive oxygen species (ROS) have become an effective tool for tumor treatment. The combination of photodynamic therapy (PDT) and chemodynamic (CDT) takes advantage various ROS enhances therapeutic effects. However, the activation CDT usually occurs before PDT, which hinders sustained maintenance hydroxyl radicals (⋅OH) reduces treatment efficiency. Herein, we present a light‐triggered nano‐system based on molecular aggregation regulation converting cancer from PDT/photothermal (PTT) to long‐lasting CDT. ordered J‐aggregation properties cyanine moiety while simultaneously suppressing capabilities copper‐porphyrin moiety. Upon light irradiation, Cu‐PCy JNPs demonstrate strong photothermal Meanwhile, triggers rapid degradation backbone, leading destruction J‐aggregation. As result, is sequentially activated, generation ⋅OH observed up 48 hours, causing potent cellular oxidative stress apoptosis. Due their excellent accumulation, exhibit in vivo ablation through therapy. This work provides new approach effectively prolonging activity ROS‐based

Language: Английский

Citations

38
Harnessing Cyanine Reactivity for Optical Imaging and Drug Delivery DOI

Alexander P. Gorka,

Roger R. Nani,

Martin J. Schnermann

et al.

Accounts of Chemical Research, Journal Year: 2018, Volume and Issue: 51(12), P. 3226 - 3235

Published: Nov. 12, 2018

ConspectusOptical approaches that visualize and manipulate biological processes have transformed modern biomedical research. An enduring challenge is to translate these powerful methods into increasingly complex physiological settings. Longer wavelengths, typically in the near-infrared (NIR) range (∼650–900 nm), can enable advances both fundamental clinical settings; however, suitable probe molecules are needed. The pentamethine heptamethine cyanines, led by prototypes Cy5 Cy7, among most useful compounds for fluorescence-based applications, finding broad use a of contexts. defining chemical feature molecules, key chromophoric element, an odd-numbered polymethine links two nitrogen atoms. Not only light-harvesting functional group, cyanine chromophore subject thermal photochemical reactions dramatically alter many properties molecules.This Account describes our recent studies define intrinsic reactivity. hypothesis driving this research novel chemistries be used address challenging problems areas imaging drug delivery. We first review reaction discovery efforts seek limitations long-wavelength fluorophores: undesired thiol reactivity modest fluorescence quantum yield. Heptamethine cyanines with O-alkyl substituent at central C4′ carbon were prepared through N- O-transposition reaction. Unlike commonly C4′-phenol variants, new class fluorophores resistant modification exhibits improved vivo when as antibody tags. also developed strategy enhance yield far-red cyanines. Using synthetic involving cross metathesis/tetracyclization sequence, approach conformationally restrains scaffold. resulting exhibit enhanced (ΦF = 0.69 vs ΦF 0.15). Furthermore, conformational restraint improves interconversion between reduced hydrocyanine intact forms, which enables super resolution microscopy.This then highlights NIR photocaging. Our involves deliberate photooxidation, previously associated photodegradation. uncaging sequence initiated photooxidative cleavage (using wavelengths up 780 prompts C–N bond hydrolysis/cyclization phenol liberation. This has been applied generate NIR-activated antibody-drug conjugates. Tumor uptake monitored using fluorescence, prior external irradiation source. slow tumor progression increase survival MDA-MB-468-luc mouse model. Broadly, vantage point providing auspicious features delivery

Language: Английский

Citations

149