Ultrafine Titanium Monoxide (TiO_1+x) Nanorods for Enhanced Sonodynamic Therapy

Journal of the American Chemical Society, Год журнала: 2020, Номер 142(14), С. 6527 - 6537

Опубликована: Март 19, 2020

Ultrasound (US)-triggered sonodynamic therapy (SDT) that enables noninvasive treatment of large internal tumors has attracted widespread interest. For improvement in the therapeutic responses to SDT, more effective and stable sonosensitizers are still required. Herein, ultrafine titanium monoxide nanorods (TiO1+x NRs) with greatly improved sono-sensitization Fenton-like catalytic activity were fabricated used for enhanced SDT. TiO1+x NRs an rodlike structure successfully prepared then modified polyethylene glycol (PEG). Compared conventional sonosensitizer, TiO2 nanoparticles, PEG–TiO1+x resulted much efficient US-induced generation reactive oxygen species (ROS) because oxygen-deficient NR, which predominantly serves as charge trap limit recombination US-triggered electron–hole pairs. Interestingly, also exhibit horseradish-peroxidase-like nanozyme can produce hydroxyl radicals (•OH) from endogenous H2O2 tumor enable chemodynamic (CDT). Because their passive retention post intravenous injection, be a sonosensitizer CDT agent highly ablation under US treatment. In addition, no significant long-term toxicity was found treated mice. This work highlights new type titanium-based nanostructure great performance

Язык: Английский

---

Ultrasmall Iron-Doped Titanium Oxide Nanodots for Enhanced Sonodynamic and Chemodynamic Cancer Therapy

ACS Nano, Год журнала: 2020, Номер 14(11), С. 15119 - 15130

Опубликована: Ноя. 13, 2020

Sonodynamic therapy (SDT), which can generate reactive oxygen species (ROS) based on sonosensitizers under ultrasound (US) to kill tumor cells, has emerged as a noninvasive therapeutic modality with high tissue-penetration depth. Herein, ultrasmall iron-doped titanium oxide nanodots (Fe-TiO2 NDs) are synthesized via thermal decomposition strategy type of enhance SDT. Interestingly, the Fe doping in this system appears be crucial not only enhancing US-triggered ROS generation those NDs but also offering Fenton-catalytic function from endogenous H2O2 for chemodynamic (CDT). After polyethylene glycol (PEG) modification, Fe-TiO2-PEG demonstrate good physiological stability and biocompatibility. With efficient retention after intravenous injection revealed by vivo magnetic resonance (MR) fluorescent imaging, our Fe-TiO2 much better performance than commercial TiO2 nanoparticles owing combination CDT Moreover, most effectively excreted within one month, rendering no obvious long-term toxicity treated mice. Our work thus presents multifunctional sonosensitizer highly cancer treatment simply nanostructures metal ions.

Язык: Английский

---

Conferring Ti‐Based MOFs with Defects for Enhanced Sonodynamic Cancer Therapy

Advanced Materials, Год журнала: 2021, Номер 33(18)

Опубликована: Апрель 1, 2021

Abstract The development of highly efficient, multifunctional, and biocompatible sonosensitizer is still a priority for current sonodynamic therapy (SDT). Herein, defect‐rich Ti‐based metal–organic framework (MOF) (D‐MOF(Ti)) with greatly improved sonosensitizing effect simply constructed used enhanced SDT. Compared the commonly TiO 2 , D‐MOF(Ti) results in superior reactive oxygen species (ROS) yield under ultrasound (US) irradiation due to its narrow bandgap, which principally improves US‐triggered electron–hole separation. Meanwhile, existence Ti 3+ ions, also exhibits high level Fenton‐like activity enable chemodynamic therapy. Particularly, US as excitation source SDT can simultaneously enhance reaction achieve remarkably synergistic outcomes oncotherapy. More importantly, be degraded metabolized out body after completion therapeutic functions without off‐target toxicity. Overall, this work identifies novel Ti‐familial harboring great potential cancer

Язык: Английский

---

Ultrasonic activation of inert poly(tetrafluoroethylene) enables piezocatalytic generation of reactive oxygen species

Nature Communications, Год журнала: 2021, Номер 12(1)

Опубликована: Июнь 9, 2021

Язык: Английский

---

Engineering Macrophage Exosome Disguised Biodegradable Nanoplatform for Enhanced Sonodynamic Therapy of Glioblastoma

Advanced Materials, Год журнала: 2022, Номер 34(15)

Опубликована: Фев. 8, 2022

Sonodynamic therapy (SDT) exhibits high tissue penetration and negligible radiation damage to normal tissues, thus emerges as a promising cancer therapeutic modality for glioblastoma (GBM). However, the blood-brain barrier (BBB) hypoxic microenvironment greatly limit SDT efficiency. In this work, biodegradable nanoplatform (termed CSI) is fabricated by encapsulating catalase (CAT) into silica nanoparticles (CAT@SiO2 ) tumor hypoxia relief, then loaded with sonosensitizer indocyanine green (ICG). Inspired ability of macrophages cross BBB, CSI further coated AS1411 aptamer-modified macrophage exosomes form CSI@Ex-A, which possesses efficient BBB good cancer-cell-targeting capability. After cell endocytosis, highly expressed glutathione (GSH) triggeres biodegradation released CAT catalyzes hydrogen peroxide (H2 O2 produce relieve hypoxia. The GSH depletion self-supplying effectively enhances efficiency both in vitro vivo. addition, resulting CSI@Ex-A biocompatibility long circulation time. These findings demonstrate that may serve competent GBM therapy, potential clinical translation.

Язык: Английский

---

2D Piezoelectric Bi₂MoO₆ Nanoribbons for GSH‐Enhanced Sonodynamic Therapy

Advanced Materials, Год журнала: 2021, Номер 33(51)

Опубликована: Окт. 16, 2021

Abstract Reducing the scavenging capacity of reactive oxygen species (ROS) and elevating ROS production are two primary goals developing novel sonosensitizers for sonodynamic therapy (SDT). Hence, ultrathin 2D Bi 2 MoO 6 –poly(ethylene glycol) nanoribbons (BMO NRs) designed as piezoelectric glutathione (GSH)‐enhanced SDT. In cancer cells, BMO NRs can consume endogenous GSH to disrupt redox homeostasis, GSH‐activated (GBMO) exhibit an oxygen‐deficient structure, which promote separation electron–hole pairs, thereby enhancing efficiency in The GBMO piezoelectric, ultrasonic waves introduce mechanical strain nanoribbons, resulting polarization band tilting, thus accelerating toxic production. as‐synthesized enable excellent computed tomography imaging tumors significant tumor suppression vitro vivo. A sonosensitizer‐mediated two‐step enhancement SDT process, is activated by amplified exogenous ultrasound, proposed. This process not only provides new options improving but also broadens application materials

Язык: Английский

---

Piezoelectric nanocomposites for sonodynamic bacterial elimination and wound healing

Nano Today, Год журнала: 2021, Номер 37, С. 101104 - 101104

Опубликована: Фев. 21, 2021

Язык: Английский

---

Preparation of TiH1.924 nanodots by liquid-phase exfoliation for enhanced sonodynamic cancer therapy

Nature Communications, Год журнала: 2020, Номер 11(1)

Опубликована: Июль 24, 2020

Abstract Metal hydrides have been rarely used in biomedicine. Herein, we fabricate titanium hydride (TiH 1.924 ) nanodots from its powder form via the liquid-phase exfoliation, and apply these metal for effective cancer treatment. The exfoliation is an method to synthesize nanomaterials, efficiency determined by matching of surface energy between solvent hydrides. obtained TiH can produce reactive oxygen species (ROS) under ultrasound, presenting a highly efficient sono-sensitizing effect. Meanwhile, with strong near-infrared (NIR) absorbance serve as robust photothermal agent. By using mild effect enhance intra-tumoral blood flow improve tumor oxygenation, remarkable synergistic therapeutic achieved combined photothermal-sonodynamic therapy. Importantly, most be cleared out body. This work presents promises functional nanomaterials biomedical applications.

Язык: Английский

---

Gathering brings strength: How organic aggregates boost disease phototheranostics

Aggregate, Год журнала: 2021, Номер 2(1), С. 95 - 113

Опубликована: Янв. 22, 2021

Abstract Phototheranostics that concurrently and complementarily integrate real‐time diagnosis in situ therapeutic capabilities one platform has become the advancing edge of precision medicine. Organic agents possess merits facile preparation, high purity, tunable photophysical property, good biocompatibility, potential biodegradability, which have shown great promise for disease theranostics. This review summarizes recent achievements organic phototheranostic applications, especially rationally utilize energy dissipation pathways Jablonski diagram to modulate fluorescence emission, photoacoustic/photothermal production, photodynamic processes. Of particular interest are systems exhibiting huge differences aggregate state as compared with solution or single molecule form, during intramolecular motions play an important role regulating properties. The advances from such aspect biomedical applications including high‐resolution imaging, activatable imaging therapy, adaptive theranostics, image‐guided surgery, immunotherapy, afterglow discussed. A brief summary perspective this field also presented. We hope will be helpful researchers interested bioprobe design theranostic inspire new insights into linkage between science field.

Язык: Английский

---

Advances and perspectives in organic sonosensitizers for sonodynamic therapy

Coordination Chemistry Reviews, Год журнала: 2021, Номер 445, С. 214087 - 214087

Опубликована: Июнь 28, 2021

Язык: Английский

---