Bioactive Materials,
Год журнала:
2021,
Номер
8, С. 409 - 419
Опубликована: Июнь 30, 2021
Sonodynamic
therapy
(SDT)
has
attracted
widespread
interest
in
biomedicine,
owing
to
its
novel
and
noninvasive
therapeutic
method
triggered
by
ultrasound
(US).
Herein,
the
Ti3C2
MXene
nanosheets
(Ti3C2
NSs)
are
developed
as
good
sonosensitizers
via
a
two-step
of
chemical
exfoliation
high-temperature
treatment.
With
treatment,
oxygen
defect
(H–Ti3C2
is
greatly
increased.
Therefore,
electron
(e−)
hole
(h+)
generated
US
can
be
separated
faster
due
improved
degree
oxidation,
then
recombination
e−-h+
prevented
with
abundant
under
irradiation,
which
induced
sonodynamic
efficiency
improve
around
3.7-fold
compared
NSs
without
After
PEGylation,
H–Ti3C2-PEG
show
stability
biocompatibility.
In
vitro
studies
exhibit
that
inherent
property
mild
photothermal
effect
promote
endocytosis
NSs,
SDT
efficacy.
vivo
further
display
increased
blood
supply
significantly
relieve
hypoxia
tumor
microenvironment,
showing
(PTT)
enhanced
SDT.
Most
importantly,
biodegraded
excreted
out
body,
no
significant
long-term
toxicity.
Our
work
develops
defective
H–Ti3C2
high-efficiency
safe
for
photothermal-enhanced
cancer,
extending
biomedical
application
MXene-based
nanoplatforms.
Journal of the American Chemical Society,
Год журнала:
2020,
Номер
142(14), С. 6527 - 6537
Опубликована: Март 19, 2020
Ultrasound
(US)-triggered
sonodynamic
therapy
(SDT)
that
enables
noninvasive
treatment
of
large
internal
tumors
has
attracted
widespread
interest.
For
improvement
in
the
therapeutic
responses
to
SDT,
more
effective
and
stable
sonosensitizers
are
still
required.
Herein,
ultrafine
titanium
monoxide
nanorods
(TiO1+x
NRs)
with
greatly
improved
sono-sensitization
Fenton-like
catalytic
activity
were
fabricated
used
for
enhanced
SDT.
TiO1+x
NRs
an
rodlike
structure
successfully
prepared
then
modified
polyethylene
glycol
(PEG).
Compared
conventional
sonosensitizer,
TiO2
nanoparticles,
PEG–TiO1+x
resulted
much
efficient
US-induced
generation
reactive
oxygen
species
(ROS)
because
oxygen-deficient
NR,
which
predominantly
serves
as
charge
trap
limit
recombination
US-triggered
electron–hole
pairs.
Interestingly,
also
exhibit
horseradish-peroxidase-like
nanozyme
can
produce
hydroxyl
radicals
(•OH)
from
endogenous
H2O2
tumor
enable
chemodynamic
(CDT).
Because
their
passive
retention
post
intravenous
injection,
be
a
sonosensitizer
CDT
agent
highly
ablation
under
US
treatment.
In
addition,
no
significant
long-term
toxicity
was
found
treated
mice.
This
work
highlights
new
type
titanium-based
nanostructure
great
performance
ACS Nano,
Год журнала:
2020,
Номер
14(11), С. 15119 - 15130
Опубликована: Ноя. 13, 2020
Sonodynamic
therapy
(SDT),
which
can
generate
reactive
oxygen
species
(ROS)
based
on
sonosensitizers
under
ultrasound
(US)
to
kill
tumor
cells,
has
emerged
as
a
noninvasive
therapeutic
modality
with
high
tissue-penetration
depth.
Herein,
ultrasmall
iron-doped
titanium
oxide
nanodots
(Fe-TiO2
NDs)
are
synthesized
via
thermal
decomposition
strategy
type
of
enhance
SDT.
Interestingly,
the
Fe
doping
in
this
system
appears
be
crucial
not
only
enhancing
US-triggered
ROS
generation
those
NDs
but
also
offering
Fenton-catalytic
function
from
endogenous
H2O2
for
chemodynamic
(CDT).
After
polyethylene
glycol
(PEG)
modification,
Fe-TiO2-PEG
demonstrate
good
physiological
stability
and
biocompatibility.
With
efficient
retention
after
intravenous
injection
revealed
by
vivo
magnetic
resonance
(MR)
fluorescent
imaging,
our
Fe-TiO2
much
better
performance
than
commercial
TiO2
nanoparticles
owing
combination
CDT
Moreover,
most
effectively
excreted
within
one
month,
rendering
no
obvious
long-term
toxicity
treated
mice.
Our
work
thus
presents
multifunctional
sonosensitizer
highly
cancer
treatment
simply
nanostructures
metal
ions.
Advanced Materials,
Год журнала:
2021,
Номер
33(18)
Опубликована: Апрель 1, 2021
Abstract
The
development
of
highly
efficient,
multifunctional,
and
biocompatible
sonosensitizer
is
still
a
priority
for
current
sonodynamic
therapy
(SDT).
Herein,
defect‐rich
Ti‐based
metal–organic
framework
(MOF)
(D‐MOF(Ti))
with
greatly
improved
sonosensitizing
effect
simply
constructed
used
enhanced
SDT.
Compared
the
commonly
TiO
2
,
D‐MOF(Ti)
results
in
superior
reactive
oxygen
species
(ROS)
yield
under
ultrasound
(US)
irradiation
due
to
its
narrow
bandgap,
which
principally
improves
US‐triggered
electron–hole
separation.
Meanwhile,
existence
Ti
3+
ions,
also
exhibits
high
level
Fenton‐like
activity
enable
chemodynamic
therapy.
Particularly,
US
as
excitation
source
SDT
can
simultaneously
enhance
reaction
achieve
remarkably
synergistic
outcomes
oncotherapy.
More
importantly,
be
degraded
metabolized
out
body
after
completion
therapeutic
functions
without
off‐target
toxicity.
Overall,
this
work
identifies
novel
Ti‐familial
harboring
great
potential
cancer
Advanced Materials,
Год журнала:
2022,
Номер
34(15)
Опубликована: Фев. 8, 2022
Sonodynamic
therapy
(SDT)
exhibits
high
tissue
penetration
and
negligible
radiation
damage
to
normal
tissues,
thus
emerges
as
a
promising
cancer
therapeutic
modality
for
glioblastoma
(GBM).
However,
the
blood-brain
barrier
(BBB)
hypoxic
microenvironment
greatly
limit
SDT
efficiency.
In
this
work,
biodegradable
nanoplatform
(termed
CSI)
is
fabricated
by
encapsulating
catalase
(CAT)
into
silica
nanoparticles
(CAT@SiO2
)
tumor
hypoxia
relief,
then
loaded
with
sonosensitizer
indocyanine
green
(ICG).
Inspired
ability
of
macrophages
cross
BBB,
CSI
further
coated
AS1411
aptamer-modified
macrophage
exosomes
form
CSI@Ex-A,
which
possesses
efficient
BBB
good
cancer-cell-targeting
capability.
After
cell
endocytosis,
highly
expressed
glutathione
(GSH)
triggeres
biodegradation
released
CAT
catalyzes
hydrogen
peroxide
(H2
O2
produce
relieve
hypoxia.
The
GSH
depletion
self-supplying
effectively
enhances
efficiency
both
in
vitro
vivo.
addition,
resulting
CSI@Ex-A
biocompatibility
long
circulation
time.
These
findings
demonstrate
that
may
serve
competent
GBM
therapy,
potential
clinical
translation.
Advanced Materials,
Год журнала:
2021,
Номер
33(51)
Опубликована: Окт. 16, 2021
Abstract
Reducing
the
scavenging
capacity
of
reactive
oxygen
species
(ROS)
and
elevating
ROS
production
are
two
primary
goals
developing
novel
sonosensitizers
for
sonodynamic
therapy
(SDT).
Hence,
ultrathin
2D
Bi
2
MoO
6
–poly(ethylene
glycol)
nanoribbons
(BMO
NRs)
designed
as
piezoelectric
glutathione
(GSH)‐enhanced
SDT.
In
cancer
cells,
BMO
NRs
can
consume
endogenous
GSH
to
disrupt
redox
homeostasis,
GSH‐activated
(GBMO)
exhibit
an
oxygen‐deficient
structure,
which
promote
separation
electron–hole
pairs,
thereby
enhancing
efficiency
in
The
GBMO
piezoelectric,
ultrasonic
waves
introduce
mechanical
strain
nanoribbons,
resulting
polarization
band
tilting,
thus
accelerating
toxic
production.
as‐synthesized
enable
excellent
computed
tomography
imaging
tumors
significant
tumor
suppression
vitro
vivo.
A
sonosensitizer‐mediated
two‐step
enhancement
SDT
process,
is
activated
by
amplified
exogenous
ultrasound,
proposed.
This
process
not
only
provides
new
options
improving
but
also
broadens
application
materials
Nature Communications,
Год журнала:
2020,
Номер
11(1)
Опубликована: Июль 24, 2020
Abstract
Metal
hydrides
have
been
rarely
used
in
biomedicine.
Herein,
we
fabricate
titanium
hydride
(TiH
1.924
)
nanodots
from
its
powder
form
via
the
liquid-phase
exfoliation,
and
apply
these
metal
for
effective
cancer
treatment.
The
exfoliation
is
an
method
to
synthesize
nanomaterials,
efficiency
determined
by
matching
of
surface
energy
between
solvent
hydrides.
obtained
TiH
can
produce
reactive
oxygen
species
(ROS)
under
ultrasound,
presenting
a
highly
efficient
sono-sensitizing
effect.
Meanwhile,
with
strong
near-infrared
(NIR)
absorbance
serve
as
robust
photothermal
agent.
By
using
mild
effect
enhance
intra-tumoral
blood
flow
improve
tumor
oxygenation,
remarkable
synergistic
therapeutic
achieved
combined
photothermal-sonodynamic
therapy.
Importantly,
most
be
cleared
out
body.
This
work
presents
promises
functional
nanomaterials
biomedical
applications.
Aggregate,
Год журнала:
2021,
Номер
2(1), С. 95 - 113
Опубликована: Янв. 22, 2021
Abstract
Phototheranostics
that
concurrently
and
complementarily
integrate
real‐time
diagnosis
in
situ
therapeutic
capabilities
one
platform
has
become
the
advancing
edge
of
precision
medicine.
Organic
agents
possess
merits
facile
preparation,
high
purity,
tunable
photophysical
property,
good
biocompatibility,
potential
biodegradability,
which
have
shown
great
promise
for
disease
theranostics.
This
review
summarizes
recent
achievements
organic
phototheranostic
applications,
especially
rationally
utilize
energy
dissipation
pathways
Jablonski
diagram
to
modulate
fluorescence
emission,
photoacoustic/photothermal
production,
photodynamic
processes.
Of
particular
interest
are
systems
exhibiting
huge
differences
aggregate
state
as
compared
with
solution
or
single
molecule
form,
during
intramolecular
motions
play
an
important
role
regulating
properties.
The
advances
from
such
aspect
biomedical
applications
including
high‐resolution
imaging,
activatable
imaging
therapy,
adaptive
theranostics,
image‐guided
surgery,
immunotherapy,
afterglow
discussed.
A
brief
summary
perspective
this
field
also
presented.
We
hope
will
be
helpful
researchers
interested
bioprobe
design
theranostic
inspire
new
insights
into
linkage
between
science
field.