Advanced Synthesis & Catalysis,
Год журнала:
2023,
Номер
365(22), С. 3915 - 3926
Опубликована: Сен. 12, 2023
Abstract
A
rhodium‐catalyzed
[5+1]
cycloaddition
via
C−H
activation/
O
‐annulation
strategy
for
synthesizing
biologically
interesting
isochromenes
is
presented.
This
protocol
selectively
provides
divergently
functionalized
containing
spirosuccinimide
and
maleimide
scaffolds
according
to
the
maleimides
itaconimides
used
as
substrates.
methodology
exhibits
an
extensive
substrate
scope,
remarkable
functional
group
tolerance,
high
regioselectivity.
Abstract
Selective
and
concise
construction
of
ring
systems
that
are
ubiquitous
skeletons
across
chemistry,
drugs
materials,
is
indispensable
for
human
life.
Of
note,
directed
C−H
annulation
with
alkynes
the
expedient
delivery
holds
great
importance,
featuring
step‐
atom‐economy,
mild
conditions,
broad
substrate
scope.
However,
regioselectivity
issues
remained
when
using
unsymmetrical
annulation.
Herein,
we
summarized
recent
achievements
towards
solving
this
problem
by
developing
directing
groups,
metal
catalysts,
versatile
traceless
functionality
ensure
overall
regioselectivity,
enantioselectivity,
efficiency,
synthetic
application.
We
hope
concept
will
promote
further
development
precise
functional
molecules
alkynes.
Organic Letters,
Год журнала:
2021,
Номер
23(10), С. 3844 - 3849
Опубликована: Апрель 19, 2021
A
unique
Rh(III)-catalyzed
C–H
activation/[3
+
2]
annulation
of
N-phenoxyacetamides
has
been
developed
for
the
construction
dihydrobenzofurans
via
carbooxygenation
1,3-dienes.
This
transformation
features
a
redox-neutral
process
with
specific
chemoselectivity,
good
substrate/functional
group
compatibility,
and
profound
synthetic
potentials.
preliminary
exploration
to
realize
their
asymmetric
synthesis
have
also
successfully
demonstrated,
which
further
strengthens
practicality
this
approach.
Organic Chemistry Frontiers,
Год журнала:
2023,
Номер
10(18), С. 4516 - 4521
Опубликована: Янв. 1, 2023
Zinc-catalyzed
[5
+
1]
annulation
of
α-hydroxyl
aryl
ketones
with
cyclohexadienone-tethered
enones
has
been
developed,
giving
access
to
enantioenriched
bicyclic
pyran
scaffolds
bearing
two
oxa-quaternary
stereocenters.
Advanced Synthesis & Catalysis,
Год журнала:
2023,
Номер
365(22), С. 3915 - 3926
Опубликована: Сен. 12, 2023
Abstract
A
rhodium‐catalyzed
[5+1]
cycloaddition
via
C−H
activation/
O
‐annulation
strategy
for
synthesizing
biologically
interesting
isochromenes
is
presented.
This
protocol
selectively
provides
divergently
functionalized
containing
spirosuccinimide
and
maleimide
scaffolds
according
to
the
maleimides
itaconimides
used
as
substrates.
methodology
exhibits
an
extensive
substrate
scope,
remarkable
functional
group
tolerance,
high
regioselectivity.
