Biomaterials, Год журнала: 2021, Номер 279, С. 121201 - 121201
Опубликована: Окт. 22, 2021
Язык: Английский
Advanced Materials, Год журнала: 2024, Номер 36(19)
Опубликована: Фев. 26, 2024
The eradication of osteomyelitis caused by methicillin-resistant Staphylococcus aureus (MRSA) poses a significant challenge due to its development biofilm-induced antibiotic resistance and impaired innate immunity, which often leads frequent surgical failure. Here, the design, synthesis, performance X-ray-activated polymer-reinforced nanotherapeutics that modulate immunological properties infectious microenvironments enhance chemoradiotherapy against multidrug-resistant bacterial deep-tissue infections are reported. Upon X-ray radiation, proposed nanotherapeutic generates reactive oxygen species nitrogen species. To robustly eradicate MRSA biofilms at deep infection sites, these can specifically bind penetrate for enhanced treatment. immunity macrophages prevent recurrence osteomyelitis. remarkable anti-infection effects validated using rat model. This study demonstrates potential synergistic immunotherapy method treating biofilm-infected
Язык: Английский
Процитировано
12
Advanced Functional Materials, Год журнала: 2024, Номер 34(45)
Опубликована: Июнь 28, 2024
Abstract Sonodynamic therapy (SDT) is promising for combating deep‐seated infectious diseases by generating substantial reactive oxygen species (ROS) through the profound tissue penetration capabilities of ultrasound. However, compact protective structures bacterial biofilms present a formidable challenge, impeding ROS efficacy. Given that have limited diffusion range and current sonosensitizers struggle to infiltrate biofilms, complete eradication pathogenic bacteria often remains unachieved. In this study, mesoporous titanium dioxide (TiO 2 ) nanoparticles are engineered asymmetrically coated with thin layer Ag loaded L‐arginine (LA) construct ultrasound‐propelled nanomotors. These Ag‐TiO ‐LA Janus demonstrate robust self‐propulsion upon ultrasonic activation, allowing deeper into biofilm matrices enhancing localized disruption improved SDT outcomes. Additionally, incorporation not only broadens TiO ’s absorption spectrum but also confers photothermal NIR laser excitation at 808 nm. The nanomotor amalgamates sonodynamic potential Ag's properties, forging versatile antimicrobial agent capable efficient synergistic antibacterial effect when subjected dual ultrasound stimuli. This innovative, singularly‐structured nanoparticle stands out as an effective combatant against accelerates healing process infected wounds, showcasing multifaceted clinical applications.
Язык: Английский
Процитировано
12
ACS Applied Materials & Interfaces, Год журнала: 2025, Номер 17(2), С. 3608 - 3619
Опубликована: Янв. 2, 2025
Bacterial biofilms are complex multicellular communities that adhere firmly to solid surfaces. They widely recognized as major threats human health, contributing issues such persistent infections on medical implants and severe contamination in drinking water systems. As a potential treatment for biofilms, this work proposes two strategies: (i) light-driven ZnFe2O4 (ZFO)/Pt microrobots photodegradation of (ii) magnetically driven ZFO mechanical removal from Magnetically were realized by synthesizing microspheres through low-cost large-scale hydrothermal synthesis, followed calcination process. Then, Pt layer was deposited the surface break their symmetry, resulting self-propelled Janus ZFO/Pt microrobots. Light-driven exhibited active locomotion under UV light irradiation controllable motion terms "stop go" features. capable maneuvering precisely when subjected an external rotating magnetic field. These could eliminate Gram-negative Escherichia coli (E. coli) photogenerated reactive oxygen species (ROS)-related antibacterial properties combination with light-powered locomotion, accelerating mass transfer remove more effectively water. Moreover, actuation allowed physical disruption which represents reliable alternative photocatalysis strongly anchored confined spaces. With versatile characteristics, envisioned highlight significant biofilm high efficacy both open spaces, pipelines industrial plants.
Язык: Английский
Процитировано
2
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 159367 - 159367
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
2
Biomaterials, Год журнала: 2021, Номер 279, С. 121201 - 121201
Опубликована: Окт. 22, 2021
Язык: Английский
Процитировано
49