Recent advances in sonodynamic-derived synergistic strategies against bacterial infections

Chemical Engineering Journal, Год журнала: 2025, Номер 508, С. 160962 - 160962

Опубликована: Фев. 25, 2025

Язык: Английский

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F_OF₁-ATPase Biomolecular Motor: Structure, Motility Manipulations, and Biomedical Applications

Biomacromolecules, Год журнала: 2025, Номер unknown

Опубликована: Янв. 11, 2025

Biomolecular motors are dynamic systems found in organisms with high energy conversion efficiency. FOF1-ATPase is a rotary biomolecular motor known for its near 100% It utilizes the synthesis and hydrolysis of ATP to induce conformational changes proteins, thereby converting chemical into mechanical motion. Given their efficiency, autonomous propulsion capability, modifiable structures, have attracted significant attention potential biomedical applications. This Review aims introduce detailed structure FOF1-ATPase, explore various motility manipulation strategies, summarize applications biological detection cargo delivery. Additionally, innovative research methods proposed analyze motion mechanism more comprehensively, goal advancing Finally, this concludes key insights future perspectives.

Язык: Английский

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Nitric Oxide‐Mediated Dual‐Functional Smart Titanium Implant Coating for Antibacterial and Osseointegration Promotion in Implant‐Associated Infections

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 8, 2025

Abstract The balance of antibacterial and osseointegration‐promoting properties on titanium (Ti) implants in a simple efficient manner is crucial for the management implant‐associated infections, condition that has become significant global health concern. Herein, nitric oxide (NO)‐mediated dual‐function smart coating with developed Ti implants. leverages distinct NO at high low concentrations to enable an on‐demand functional switch. Specifically, function achieved through rapid release high‐dose response infection microenvironment near‐infrared stimulation. Once resolved normal physiological conditions are restored, gradually releases low‐dose promote osseointegration. In vitro tests confirm exhibits ratio 97.84% 97.18% against methicillin‐resistant Staphylococcus aureus its biofilms, respectively, demonstrates ability activate osteoblasts. rat femoral model further certifies responsive mechanism efficiently facilitates switch between properties. Notably, use dual‐functional nonantibiotic agent, NO, significantly mitigates risk bacterial resistance.

Язык: Английский

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Nitric oxide-delivering surface modification for tailoring cell-material interactions on medical device surface: From surface-functionalized design to therapeutic applications

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 162378 - 162378

Опубликована: Апрель 1, 2025

Язык: Английский

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808 nm Light-Triggered Cyanine-Decorated Iridium(III) Complexes for Antibacterial Photodynamic Therapy in Deep-Tissue

Inorganic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 11, 2025

Acute bacterial skin and structure infections (ABSSSIs) pose significant global health challenges, exacerbated by rising antibiotic resistance. Antibacterial photodynamic therapy (APDT) has emerged as a promising strategy to combat these utilizing photosensitizer (PS) that generates reactive oxygen species (ROS) upon light activation. However, the limited tissue penetration of conventional organic PSs, which primarily absorb in UV-vis spectra, hindered their therapeutic potential for deeper infections. Herein, we introduce novel iridium(III)-cyanine complex (Ir-cy) with strong near-infrared (NIR) absorption at 814 nm (up 101 red-shifted from previous reports), specifically designed enhance APDT. Under 808 laser irradiation, Ir-cy demonstrated substantial ROS generation capacity, achieving approximately 70% reduction Staphylococcus aureus (S. aureus) colonies depth 7.2 mm within simulated model. Comprehensive vitro vivo evaluations further confirmed its potent antibacterial efficacy against S. while maintaining excellent biocompatibility. These findings highlight highly effective NIR-active PS, paving way advanced strategies targeting deep-tissue ABSSSIs through optimized

Язык: Английский

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One‐End‐Opened Yolk–Shell Copper Single‐Atom Microrobots for Enhanced Penetration and Eradication of Bacterial Biofilms

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 11, 2025

Abstract Single‐atom catalysts (SACs) hold remarkable potential for antibacterial and multidrug‐resistant Staphylococcus aureus (MRSA) biofilm eradication, but passive diffusion often restricts their effectiveness. In contrast, microrobots can harness various energy sources highly autonomous movement. Herein, a one‐end‐opened yolk–shell microrobot with Cu single atoms anchored on carbon nitride (Y‐CuSA/CN) is designed to enhance MRSA penetration effects. The Y‐CuSA/CN achieves single‐atom‐driven propulsion by generating an H 2 O gradient via Fenton‐like reaction. Furthermore, UV‐LED light (365 nm) excitation produces photogenerated electrons, which promotes the valence cycling of single‐atom reacts , thereby further boosting microrobot's mobility catalytic activity. exhibits vigorous movement velocity 17.2 µm s −1 rate 7.2 significantly enhancing its into bacterial biofilms. During motion, reactive oxygen species (·OH, ·O − 1 ) are released oxidation. vitro in vivo experiments demonstrate that effectively eradicates biofilms wound healing infected mice. This study presents efficient strategy eradicating highlights SACs developing advanced biomedical applications.

Язык: Английский

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Regulated cell death mechanisms in mitochondria-targeted phototherapy

Journal of Controlled Release, Год журнала: 2025, Номер unknown, С. 113720 - 113720

Опубликована: Апрель 1, 2025

Язык: Английский

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Micro/Nanomotors: A Novel Platform for Food Safety Detection and Auxiliary Processing

Food Bioscience, Год журнала: 2025, Номер unknown, С. 106626 - 106626

Опубликована: Апрель 1, 2025

Язык: Английский

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NIR-responsive gold nanomaterials in photothermal antibacterial therapy: From morphological design to multifunctional platforms

Coordination Chemistry Reviews, Год журнала: 2024, Номер 526, С. 216348 - 216348

Опубликована: Дек. 2, 2024

Язык: Английский

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Innovative integration of nanomedicines and phototherapy to modulate autophagy for enhanced tumor eradication

Journal of Controlled Release, Год журнала: 2024, Номер 377, С. 855 - 879

Опубликована: Дек. 7, 2024

Язык: Английский

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