Advanced Materials,
Год журнала:
2024,
Номер
36(35)
Опубликована: Май 9, 2024
The
pursuit
of
constructing
humanoid
robots
to
replicate
the
anatomical
structures
and
capabilities
human
beings
has
been
a
long-standing
significant
undertaking
especially
garnered
tremendous
attention
in
recent
years.
However,
despite
progress
made
over
decades,
have
predominantly
confined
those
rigid
metallic
structures,
which
however
starkly
contrast
with
inherent
flexibility
observed
biological
systems.
To
better
innovate
this
area,
present
work
systematically
explores
value
potential
liquid
metals
their
derivatives
facilitating
crucial
transition
towards
soft
robots.
Through
comprehensive
interpretation
bionics,
an
overview
metals'
multifaceted
roles
as
essential
components
advanced
robots-functioning
actuators,
sensors,
power
sources,
logical
devices,
circuit
systems,
even
transformable
skeletal
structures-is
presented.
It
is
conceived
that
integration
these
flexible
facilitated
by
unique
properties
metals,
can
create
unexpected
versatile
functionalities
behaviors
fulfill
needs.
Finally,
revolution
envisioned,
transitioning
from
frameworks
hybrid
soft-rigid
resembling
tissues.
This
study
expected
provide
fundamental
guidance
for
coming
research,
thereby
advancing
area.
Advanced Materials,
Год журнала:
2022,
Номер
34(34)
Опубликована: Апрель 27, 2022
Biofilm
eradication
from
medical
implants
is
of
fundamental
importance,
and
the
treatment
biofilm-associated
pathogen
infections
on
inaccessible
biliary
stents
remains
challenging.
Magnetically
driven
microrobots
with
controlled
motility,
accessibility
to
tiny
lumen,
swarm
enhancement
effects
can
physically
disrupt
deleterious
biostructures
while
not
developing
drug
resistance.
Magnetic
urchin-like
capsule
robots
(MUCRs)
loaded
magnetic
liquid
metal
droplets
(MLMDs,
antibacterial
agents)
are
designed
using
natural
sunflower
pollen,
therapeutic
effect
swarming
MUCR@MLMDs
explored
for
eradicating
complex
mixtures
bacterial
biofilm
within
collected
patients.
The
external
field
triggers
emergence
microswarm
induces
MLMDs
transform
their
shape
into
spheroids
rods
sharp
edges.
inherent
microspikes
MUCRs
obtained
edges
actively
rupture
dense
biological
matrix
multiple
species
embedded
cells
by
exerting
mechanical
force,
finally
achieving
synergistic
eradication.
precisely
rapidly
deployed
stent
via
endoscopy
in
10
min.
Notably,
fluoroscopy
imaging
used
track
navigate
locomotion
real-time.
has
great
potential
treating
associated
implants.
Chemical Society Reviews,
Год журнала:
2022,
Номер
51(24), С. 10083 - 10119
Опубликована: Янв. 1, 2022
Micro/nanomotors
with
advanced
motion
manipulation
show
great
promise
in
biomedical
fields.
This
review
article
critically
summarizes
the
working
principles,
strategies,
applications,
and
future
prospects
of
micro/nanomotors.
Advanced Materials,
Год журнала:
2022,
Номер
34(52)
Опубликована: Апрель 6, 2022
Cancer
is
one
of
the
most
intractable
diseases
owing
to
its
high
mortality
rate
and
lack
effective
diagnostic
treatment
tools.
Advancements
in
micro-/nanorobot
(MNR)-assisted
sensing,
imaging,
therapeutics
offer
unprecedented
opportunities
develop
MNR-based
cancer
theragnostic
platforms.
Unlike
ordinary
nanoparticles,
which
exhibit
Brownian
motion
biofluids,
MNRs
overcome
viscous
resistance
an
ultralow
Reynolds
number
(Re
<<
1)
environment
by
self-propulsion.
This
unique
locomotion
property
has
motivated
advanced
design
functionalization
as
a
basis
for
next-generation
cancer-therapy
platforms,
potential
precise
distribution
improved
permeation
therapeutic
agents.
Enhanced
barrier
penetration,
imaging-guided
operation,
biosensing
are
additionally
studied
enable
promising
cancer-related
applications
MNRs.
Herein,
recent
advances
therapy
comprehensively
addresses,
including
actuation
engines,
diagnostics,
medical
targeted
drug
delivery;
research
that
can
have
profound
impact
on
over
next
decade
highlighted.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2022,
Номер
10
Опубликована: Фев. 4, 2022
With
the
abuse
and
misuse
of
antibiotics,
antimicrobial
resistance
has
become
a
challenging
issue
in
medical
system.
Iatrogenic
non-iatrogenic
infections
caused
by
multidrug-resistant
(MDR)
pathogens
pose
serious
threats
to
global
human
life
health
because
efficacy
traditional
antibiotics
been
greatly
reduced
resulting
socio-economic
burden
increased.
It
is
important
find
develop
non-antibiotic-dependent
antibacterial
strategies
development
new
can
hardly
keep
pace
with
emergence
resistant
bacteria.
Gallium
(III)
multi-target
agent
that
an
excellent
activity,
especially
against
MDR
pathogens;
thus,
gallium
(III)-based
treatment
expected
strategy.
However,
some
limitations
ions
as
antimicrobials
still
exist,
including
low
bioavailability
explosive
release.
In
recent
years,
nanomaterials
clathrates,
progress
manufacturing
technology,
synergistic
strategies,
activities
have
improved,
scope
application
systems
expanded.
This
review
summarizes
advancement
current
optimization
for
these
key
factors.
will
enrich
knowledge
about
efficiency
mechanism
various
gallium-based
agents
provide
improvement
activity
compounds.
Cyborg and Bionic Systems,
Год журнала:
2024,
Номер
5
Опубликована: Янв. 1, 2024
Untethered
and
self-transformable
miniature
robots
are
capable
of
performing
reconfigurable
deformation
on-demand
locomotion,
which
aid
the
traversal
toward
various
lumens,
bring
revolutionary
changes
for
targeted
delivery
in
gastrointestinal
(GI)
tract.
However,
viscous
non-Newtonian
liquid
environment
plicae
gastricae
obstacles
severely
hamper
high-precision
actuation
payload
delivery.
Here,
we
developed
a
low-friction
soft
robot
by
assembly
densely
arranged
cone
structures
grafting
hydrophobic
monolayers.
The
magnetic
orientation
encoded
can
move
multiple
modes,
with
substantially
reduced
drag,
terrain
adaptability,
improved
motion
velocity
across
liquids.
Notably,
stiffness
be
reversibly
controlled
magnetically
induced
hardening,
enabling
on-site
scratching
destruction
antibiotic-ineradicable
polymeric
matrix
biofilms
low-frequency
field.
Furthermore,
magnetocaloric
effect
utilized
to
eradicate
bacteria
under
high-frequency
alternating
To
verify
potential
applications
inside
body,
clinical
imaging-guided
platforms
were
vision-based
control
robots.
show
their
high
perform
bacterial
infection
therapy
lumens
body.
Lab on a Chip,
Год журнала:
2024,
Номер
24(5), С. 1419 - 1440
Опубликована: Янв. 1, 2024
Although
developed
independently
at
the
beginning,
AI,
micro/nanorobots
and
microfluidics
have
become
more
intertwined
in
past
few
years
which
has
greatly
propelled
cutting-edge
development
fields
of
biomedical
sciences.
Engineered Regeneration,
Год журнала:
2021,
Номер
2, С. 109 - 115
Опубликована: Янв. 1, 2021
Micro/nanoscale
motors(MNMs)
have
been
regarded
as
promising
tools
in
the
field
of
engineered
regeneration
due
to
unique
property
autonomous
motion.
Herein,
a
review
on
advancements
MNMs
area
is
presented,
covering
aspects
from
their
propulsion
mechanisms
frontiers
regeneration,
listing
revolutionary
applications
biosensing,
medical
imaging,
drug
delivery
and
tissue
engineering.
Finally,
challenges
future
directions
are
finally
discussed
basis
achievements.
Journal of the American Chemical Society,
Год журнала:
2021,
Номер
143(31), С. 12194 - 12201
Опубликована: Июль 22, 2021
The
coronavirus
SARS-CoV-2
can
survive
in
wastewater
for
several
days
with
a
potential
risk
of
waterborne
human
transmission,
hence
posing
challenges
containing
the
virus
and
reducing
its
spread.
Herein,
we
report
on
an
active
biohybrid
microrobot
system
that
offers
highly
efficient
capture
removal
target
from
various
aquatic
media.
algae-based
is
fabricated
by
using
click
chemistry
to
functionalize
microalgae
angiotensin-converting
enzyme
2
(ACE2)
receptor
against
spike
protein.
resulting
ACE2-algae-robot
displays
fast
(>100
μm/s)
long-lasting
(>24
h)
self-propulsion
diverse
media
including
drinking
water
river
water,
obviating
need
external
fuels.
Such
movement
effective
"on-the-fly"
proteins
pseudovirus.
Specifically,
results
95%
viral
protein
89%
pseudovirus,
significantly
exceeding
control
groups
such
as
static
ACE2-algae
bare
algae.
These
suggest
considerable
promise
biologically
functionalized
algae
toward
viruses
other
environmental
threats
wastewater.
