Synthesis,
Год журнала:
2023,
Номер
56(04), С. 567 - 572
Опубликована: Апрель 19, 2023
Abstract
Enzymatic
asymmetric
benzylic
hydroxylation
represents
a
green
synthesis
of
valuable
chiral
alcohols.
The
stereoselective
C–H
direct
profile
possessed
by
cytochrome
P450
monooxygenases
(P450s)
makes
it
more
attractive.
Here,
we
successfully
expressed
self-sufficient
monooxygenase
from
Deinococcus
gobiensis
in
Escherichia
coli
BL21(DE3)
host.
recombinant
E.
(P450DG)
strain
performed
well
terms
functionality
and
has
ability
for
propylbenzene
substrates.
Asymmetric
various
aromatic
compounds
was
further
investigated
using
the
based
on
optimal
conditions,
producing
corresponding
enantioenriched
pharmaceutically
relevant
alcohols
moderate
yields
with
good
to
excellent
enantioselectivity.
Angewandte Chemie International Edition,
Год журнала:
2022,
Номер
61(36)
Опубликована: Июнь 28, 2022
An
unprecedented
hydroalkylation
of
racemic
allylic
alcohols
and
ketimine
esters
enabled
by
Cu/Ru
relay
catalysis
has
been
developed
via
merging
the
ruthenium-catalyzed
asymmetric
borrowing-hydrogen
reaction
with
a
copper-catalyzed
Michael
addition
in
one-pot
procedure.
The
current
method
enables
efficient
preparation
highly
functionalized
δ-hydroxyesters
bearing
1,4-nonadjacent
stereocenters
good
yields
high
levels
diastereoselectivity
excellent
enantioselectivity
under
mild
conditions.
full
complement
four
stereoisomers
products
could
be
readily
accessed
orthogonal
permutations
two
chiral
metal
catalysts.
work
highlights
power
for
stereodivergent
construction
that
were
otherwise
inaccessible.
Chemical Society Reviews,
Год журнала:
2023,
Номер
52(16), С. 5541 - 5562
Опубликована: Янв. 1, 2023
Enantioconvergent
transformations
of
racemic
secondary
alcohols
to
enantioenriched
chiral
amines,
N-heterocycles,
higher-order
and
ketones
through
borrowing
hydrogen
catalysis
is
covered
in
this
review.
Journal of the American Chemical Society,
Год журнала:
2023,
Номер
145(31), С. 17329 - 17336
Опубликована: Июль 7, 2023
Despite
the
extensive
applications,
selective
and
diverse
access
to
N,N'-diarylethane-1,2-diamines
remains,
date,
a
challenge.
Here,
by
developing
bifunctional
cobalt
single-atom
catalyst
(CoSA-N/NC),
we
present
general
method
for
direct
synthesis
of
such
compounds
via
reductive
coupling
cheap
abundant
nitroarenes
formaldehyde,
featuring
good
substrate
functionality
compatibility,
an
easily
accessible
base
metal
with
excellent
reusability,
high
step
atom
efficiency.
Mechanistic
studies
reveal
that
N-anchored
single
atoms
(CoN4)
serve
as
catalytically
active
sites
reduction
processes,
N-doped
carbon
support
enriches
HCHO
timely
trap
in
situ
formed
hydroxyamines
affords
requisite
nitrones
under
weak
alkaline
conditions,
subsequent
inverse
electron
demand
1,3-dipolar
cycloaddition
imines
followed
hydrodeoxygenation
cycloadducts
furnishes
products.
In
this
work,
concept
catalyst-controlled
nitroarene
create
specific
building
blocks
is
anticipated
develop
more
useful
chemical
transformations.
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
62(37)
Опубликована: Июль 20, 2023
Chiral
induction
by
natural
biomolecules
can
reveal
the
indispensable
role
of
chiral
structures
in
life
and
be
used
to
develop
chirality-sensing
biomolecular
recognition.
Here,
we
present
synthesis
characterization
an
achiral
supramolecular
organic
framework
(SOF-1)
constructed
from
cucurbit[8]uril
(CB[8])
hexaphenylbenzene
(HPB)
derivative
(1)
water.
Due
propeller-like
rotational
conformation
HPB
units
specific
recognition
properties
CB[8],
SOF-1
demonstrates
adaptive
water
when
interacting
with
N-terminal
Trp-/Phe-containing
dipeptides
including
L-TrpX
L-PheX
(X
is
amino
acid
residue),
respectively,
exhibiting
contrasting
circular
dichroism
(CD)
circularly
polarized
luminescence
(CPL)
spectra.
Consequently,
has
been
developed
as
a
host
chiroptical
sensor
capable
recognizing
distinguishing
sequence-opposite
dipeptide
pairs
L-TrpX/L-XTrp
L-PheX/L-XPhe
based
on
sequence-selective
CD
responses.
Chemical Society Reviews,
Год журнала:
2024,
Номер
53(9), С. 4607 - 4647
Опубликована: Янв. 1, 2024
This
review
collectively
discussed
the
utilisation
of
alcohols
in
various
organic
transformations
and
their
application
toward
intermediates
drugs,
drug
derivatives
natural
product-like
molecules.
Abstract
Direct
asymmetric
hydrogenation
(AH)
and
transfer
(ATH)
are
among
the
most
efficient
approaches
to
produce
chiral
building
blocks.
Recently,
these
types
of
transformations
have
witnessed
a
shift
towards
use
molecular
catalysts
based
on
earth‐abundant
transition
metals
due
their
ready
availability,
economic
advantage,
novel
properties.
With
particular
regard
manganese,
catalyst
development
has
seen
both
efficiency
substrate
scope
in
AH
ATH
greatly
improved,
with
emergence
large
number
well‐defined
Mn‐complexes
employed
this
field.
The
reaction
includes
C=O
bonds,
reduction
C=N
bonds
reductive
C=C
bonds.
Herein,
our
survey
area
focuses
catalytic
activity
such
complexes,
versatility
routes
convert
substrates
target
molecules.
We
consider
collected
findings
article
will
be
helpful
reader
by
providing
an
insight
into
ligand
design,
thereby
aiding
future
development.
Moreover,
review
is
aimed
at
highlighting
remarkable
progress
made
last
seven
years
manganese
complexes
for
enantioselective
reduction.
Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 18, 2024
Abstract
For
traditional
metal
complexes,
intricate
chemistry
is
required
to
acquire
appropriate
ligands
for
controlling
the
electron
and
steric
hindrance
of
active
centers.
Comparatively,
preparation
single‐atom
catalysts
much
easier
with
more
straightforward
effective
accesses
arrangement
control
The
presence
coordination
atoms
or
neighboring
functional
on
supports'
surface
ensures
stability
single‐atoms
their
interactions
individual
substantially
regulate
performance
Therefore,
collaborative
interaction
between
surrounding
environment
enhances
initiation
reaction
substrates
formation
transformation
crucial
intermediate
compounds,
which
imparts
significant
catalytic
efficacy,
rendering
them
a
valuable
framework
investigating
correlation
structure
activity,
as
well
mechanism
in
organic
reactions.
Herein,
comprehensive
overviews
both
homogeneous
complexes
reactions
are
provided.
Additionally,
reflective
conjectures
about
advancement
synthesis
also
proposed
present
reference
later
development.
ACS Omega,
Год журнала:
2022,
Номер
7(42), С. 37008 - 37038
Опубликована: Окт. 11, 2022
In
recent
years,
many
manganese-based
homogeneous
catalytic
precursors
have
been
developed
as
powerful
alternatives
in
organic
synthesis.
Among
these,
the
hydrofunctionalizations
of
unsaturated
C–C
bonds
correspond
to
outstanding
ways
afford
compounds
with
more
versatile
functional
groups,
which
are
commonly
used
building
blocks
production
fine
chemicals
and
feedstock
for
industrial
field.
Herein,
we
present
an
account
Mn-catalyzed
alkenes
alkynes
main
objective
finding
mechanistic
tendencies
that
could
serve
a
platform
works
come.
Organic Process Research & Development,
Год журнала:
2023,
Номер
27(3), С. 423 - 447
Опубликована: Фев. 17, 2023
Nonprecious-metal-catalyzed
alternatives
to
powerful
precious
metal
transformations
are
of
increasing
interest
in
academia
and
the
pharmaceutical
industry
due
lower
cost,
better
sustainability,
toxicity.
With
continual
growth
broad
field
nonprecious
catalysis
(NPMC),
we
have
chosen
highlight
selected
articles
published
from
March
June
2022
which
intended
examples
NPMC
that
feel
may
be
especially
relevant
development.
We
aim
inspire
academic
industrial
innovation
through
discussion
herein.
Organic Letters,
Год журнала:
2024,
Номер
26(27), С. 5788 - 5793
Опубликована: Июнь 27, 2024
Stereocontrolled
oxa-Michael
additions
are
challenging,
given
the
high
reversibility
of
process,
which
ultimately
leads
to
racemization
newly
formed
stereocenters.
When
iron-catalyzed
borrowing
hydrogen
from
allylic
alcohols
was
combined
with
a
stereocontrolled
organocatalytic
addition,
wide
array
chiral
tetrahydropyrans
were
efficiently
prepared.
The
reaction
could
be
performed
in
diastereoselective
manner
pre-existing
stereocenters
or
enantioselectively
achiral
substrates.
key
success
reactivity
iron
complex,
selective
for
alcohol
dehydrogenation
and
irreversibly
led
final
product.