Immunogenic Cell Death Inducing Metal Complexes for Cancer Therapy

Angewandte Chemie International Edition, Год журнала: 2023, Номер 62(21)

Опубликована: Фев. 21, 2023

Cancer is one of the deadliest diseases worldwide. Recent statistics have shown that metastases and tumor relapse are leading causes cancer-associated deaths. While traditional treatments able to efficiently remove primary tumor, secondary tumors remain poorly accessible. Capitalizing on this there an urgent need for novel treatment modalities. Among most promising approaches, increasing research interest has been devoted immunogenic cell death inducing agents trigger localized cancer cells as well induce immune response inside whole organism. Preliminary studies compounds could be overcome metastatic relapsing tumors. Herein, application metal complexes systematically reviewed.

Язык: Английский

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Efficient NIR-II Type-I AIE Photosensitizer for Mitochondria-Targeted Photodynamic Therapy through Synergistic Apoptosis–Ferroptosis

ACS Nano, Год журнала: 2023, Номер 17(10), С. 9110 - 9125

Опубликована: Май 5, 2023

Hypoxia, the hallmark of malignant tumors, has been recognized as a major obstacle for photodynamic therapy (PDT). Precisely targeting cancer cells in intricate biological scenarios by hypoxia-resistant photosensitizer (PS) is cornerstone to conquer inevitable tumor recurrence and metastasis. Herein, we describe an organic NIR-II PS (TPEQM-DMA) possessing potent type-I phototherapeutic efficacy overcome intrinsic pitfalls PDT combating hypoxic tumors. TPEQM-DMA exhibited prominent emission (>1000 nm) with aggregation-induced feature efficiently produced superoxide anion hydroxyl radical aggregate state under white light irradiation exclusively through low-O2-dependent photochemical process. The suitable cationic nature assisted accumulate cancerous mitochondria. Meanwhile, impaired cellular redox homeostasis, led mitochondrial dysfunction, raised level lethal peroxidized lipids, which induced apoptosis ferroptosis. This synergistic cell death modality enabled suppress growth cells, multicellular spheroids, To improve pharmacological properties TPEQM-DMA, nanoparticles were prepared encapsulation polymer. In vivo experiments proved appealing fluorescence imaging-guided effect

Язык: Английский

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Engineering of BODIPY-based theranostics for cancer therapy

Coordination Chemistry Reviews, Год журнала: 2022, Номер 476, С. 214908 - 214908

Опубликована: Ноя. 7, 2022

Язык: Английский

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Near-infrared metal agents assisting precision medicine: from strategic design to bioimaging and therapeutic applications

Chemical Society Reviews, Год журнала: 2023, Номер 52(13), С. 4392 - 4442

Опубликована: Янв. 1, 2023

Metal agents have made incredible strides in preclinical research and clinical applications, but their short emission/absorption wavelengths continue to be a barrier distribution, therapeutic action, visual tracking, efficacy evaluation.

Язык: Английский

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Doping Engineering to Modulate Lattice and Electronic Structure for Enhanced Piezocatalytic Therapy and Ferroptosis

Advanced Materials, Год журнала: 2023, Номер 35(38)

Опубликована: Июль 12, 2023

Piezocatalytic therapy, which generates reactive oxygen species (ROS) under mechanical force, has garnered extensive attention for its use in cancer therapy owing to deep tissue penetration depth and less O2 -dependence. However, the piezocatalytic therapeutic efficiency is limited poor piezoresponse, low separation of electron-hole pairs, complicated tumor microenvironment (TME). Herein, a biodegradable, porous Mn-doped ZnO (Mn-ZnO) nanocluster with enhanced piezoelectric effect constructed via doping engineering. Mn-doping not only induces lattice distortion increase polarization but also creates rich vacancies (OV ) suppressing recombination leading high-efficiency generation ROS ultrasound irradiation. Moreover, shows TME-responsive multienzyme-mimicking activity glutathione (GSH) depletion ability mixed valence Mn (II/III), further aggravating oxidative stress. Density functional theory calculations show that can improve performance enzyme Mn-ZnO due presence OV . Benefiting from boosting GSH ability, significantly accelerate accumulation lipid peroxide inactivate peroxidase 4 (GPX4) induce ferroptosis. The work may provide new guidance exploring novel sonosensitizers therapy.

Язык: Английский

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Metal-Based Photosensitizers as Inducers of Regulated Cell Death Mechanisms

Chemical Reviews, Год журнала: 2023, Номер 123(16), С. 10135 - 10155

Опубликована: Авг. 3, 2023

Over the last few decades, various forms of regulated cell death (RCD) have been discovered and were found to improve cancer treatment. Although there are several reviews on RCD induced by photodynamic therapy (PDT), a comprehensive summary covering metal-based photosensitizers (PSs) as inducers has not yet presented. In this review, we systematically summarize works PSs that induce different types RCD, including ferroptosis, immunogenic (ICD), pyroptosis. The characteristics mechanisms each explained. At end section, reported commonalities between inducing same is emphasized, future perspectives novel discussed at review. Considering essential roles in therapy, hope review will provide stage for advances inducers.

Язык: Английский

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Engineered Metallacycle‐Based Supramolecular Photosensitizers for Effective Photodynamic Therapy

Angewandte Chemie International Edition, Год журнала: 2023, Номер 62(15)

Опубликована: Фев. 14, 2023

Abstract Although metallacycle‐based supramolecular photosensitizers (PSs) have attracted increasing attention in biomedicine, their clinical translation is still hindered by inherent dark toxicity. Herein, we report what to our knowledge the first example of a molecular engineering approach building blocks metallacycles for constructing series PSs ( RuA–RuD ), with aim simultaneously reducing toxicity and enhancing phototoxicity, consequently obtaining high phototoxicity indexes (PI). Detailed vitro investigations demonstrate that display cancer cellular uptake remarkable antitumor activity even under hypoxic conditions. Notably, RuD exhibited no displayed highest PI value (≈406). Theoretical calculations verified has largest steric hindrance lowest singlet‐triplet energy gap (Δ E ST , 0.61 eV). Further vivo studies confirmed allows safe effective phototherapy against A549 tumors.

Язык: Английский

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A review on metal complexes and its anti-cancer activities: Recent updates from in vivo studies

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 171, С. 116211 - 116211

Опубликована: Янв. 29, 2024

Research into cancer therapeutics has uncovered various potential medications based on metal-containing scaffolds after the discovery and clinical applications of cisplatin as an anti-cancer agent. This resulted in many metallodrugs that can be put medical applications. These have a wider variety functions mechanisms action than pure organic molecules. Although platinum-based medicines are very efficient agents, they often accompanied by significant side effects toxicity limited resistance. Some most studied developed alternatives to include ruthenium, gold, copper, iridium, osmium, which showed effectiveness against cell lines. metal-based represent exciting new category treatments sparked renewed interest search for effective therapies. Despite widespread development metal complexes touted powerful promising vitro therapeutics, only small percentage these compounds shown their worth vivo models. Metallodrugs, more less toxic drugs treat drug-resistant cells, focus this review. Here, we highlighted some recently Pt, Ru, Au, Cu, Ir, Os antitumor properties between 2017 2023.

Язык: Английский

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Exosome camouflaged coordination-assembled Iridium(III) photosensitizers for apoptosis-autophagy-ferroptosis induced combination therapy against melanoma

Biomaterials, Год журнала: 2023, Номер 301, С. 122212 - 122212

Опубликована: Июнь 24, 2023

Язык: Английский

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Ferroptosis: challenges and opportunities for nanomaterials in cancer therapy

Regenerative Biomaterials, Год журнала: 2023, Номер 10

Опубликована: Янв. 1, 2023

Abstract Ferroptosis, a completely new form of regulated cell death, is mainly caused by an imbalance between oxidative damage and reductive protection has shown great anti-cancer potential. However, existing small-molecule ferroptosis inducers have various limitations, such as poor water solubility, drug resistance low targeting ability, hindering their clinical applications. Nanotechnology provides opportunities for ferroptosis-driven tumor therapy. Especially, stimuli-responsive nanomaterials stand out among others been widely researched because unique spatiotemporal control advantages. Therefore, it’s necessary to summarize the application those in ferroptosis. Here, we describe physiological feature illustrate current challenges induce cancer Then, that are classified elaborated according external internal stimuli. Finally, future perspectives field proposed. We hope this review facilitates paving way design intelligent nano-ferroptosis inducers.

Язык: Английский

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