Journal of Composites Science,
Год журнала:
2025,
Номер
9(1), С. 26 - 26
Опубликована: Янв. 8, 2025
Objective:
The
aim
of
this
study
was
to
evaluate
the
cure
efficiency
and
biocompatibility
a
novel
iron-based
coordination
complex
used
as
photoinitiator
in
comparison
conventional
ethyl
(2,4,6-trimethylbenzoyl)
phenylphosphinate
(TPO-L)
camphorquinone
(CQ)
photoinitiators
dental
3D-printed
resins.
Materials
Methods:
Experimental
resin
formulations
were
prepared
by
blending
1:1
ratio
Bis-GMA
TEGDMA,
which
0.2
wt%
either
or
CQ
added,
along
with
EDAB
0.4
IOD,
TPO-L.
degree
conversion
(DC)
measured
using
Fourier
transform
infrared
spectroscopy
(FTIR).
Biocompatibility
assessed
evaluating
viability
L929
fibroblast-like
cells
MTT
assay
24
h
post-exposure.
Statistical
analyses
included
two-way
ANOVA
followed
Tukey’s
test
for
post
hoc
comparisons,
significance
at
p
<
0.05.
Results:
(84.54%
±
1.69%)
significantly
higher
than
that
TPO-L
(78.77%
1.25%)
CQ-based
resins
(73.21%
0.47%)
(p
0.001).
exhibited
Regarding
biocompatibility,
cell
revealed
demonstrated
highest
86.5%
10.24%,
80.03%
11.07%.
showed
lowest
51.29%
8.44%
0.05).
confirmed
significant
differences
between
other
photointiators
0.05),
while
no
difference
found
complex.
Conclusions:
This
introduces
demonstrates
enhanced
comparable
TPO-L,
reducing
cytotoxicity
associated
CQ.
Its
longer
absorption
wavelength
supports
deeper
layer
curing,
making
it
promising
alternative
3D
printing,
particularly
bioactive
scaffold
applications
requiring
minimized
cytotoxicity.
Abstract
Ferroptosis
is
a
new
form
of
regulated
cell
death
featuring
iron‐dependent
lipid
peroxides
accumulation
to
kill
tumor
cells.
A
growing
body
evidence
has
shown
the
potential
ferroptosis‐based
cancer
therapy
in
eradicating
refractory
malignancies
that
are
resistant
apoptosis‐based
conventional
therapies.
In
recent
years,
studies
have
reported
number
ferroptosis
inducers
can
increase
vulnerability
cells
by
regulating
ferroptosis‐related
signaling
pathways.
Encouraged
rapid
development
ferroptosis‐driven
therapies,
interdisciplinary
fields
combine
ferroptosis,
pharmaceutical
chemistry,
and
nanotechnology
focused.
First,
prerequisites
metabolic
pathways
for
briefly
introduced.
Then,
detail
emerging
designed
boost
ferroptosis‐induced
therapy,
including
metal
complexes,
metal‐based
nanoparticles,
metal‐free
nanoparticles
summarized.
Subsequently,
application
synergistic
strategies
with
apoptosis
other
emphasis
on
use
both
cuproptosis
induce
redox
dysregulation
intracellular
bimetallic
copper/iron
metabolism
disorders
during
treatment
discussed.
Finally,
challenges
associated
clinical
translation
future
directions
potentiating
therapies
highlighted.
Chemical Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 14, 2025
Ferroptosis,
an
iron-dependent
form
of
regulatory
cell
death,
has
garnered
significant
interest
as
a
therapeutic
target
in
cancer
treatment
due
to
its
distinct
characteristics,
including
lipid
peroxide
generation
and
redox
imbalance.
However,
clinical
application
oncology
is
currently
limited
by
issues
such
suboptimal
efficacy
potential
off-target
effects.
The
advent
nanotechnology
provided
new
way
for
overcoming
these
challenges
through
the
development
activatable
magnetic
nanoparticles
(MNPs).
These
innovative
MNPs
are
designed
improve
specificity
ferroptosis
induction.
This
Review
delves
into
chemical
biological
principles
guiding
design
ferroptosis-based
therapies
imaging-guided
therapies.
It
discusses
mechanisms
attributes
ferroptosis,
composition
MNPs,
their
mechanism
action
inducers,
integration
with
advanced
imaging
techniques
monitoring.
Additionally,
we
examine
convergence
other
strategies,
chemodynamic
therapy,
photothermal
photodynamic
sonodynamic
immunotherapy,
within
context
nanomedicine
strategies
utilizing
MNPs.
highlights
multifunctional
surpass
limitations
conventional
treatments,
envisioning
future
drug-resistance-free,
precision
diagnostics
treating
recalcitrant
cancers.
Chemical Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 27, 2025
Nanozymes
have
shown
significant
potential
in
cancer
catalytic
therapy
by
strategically
catalyzing
tumor-associated
substances
and
metabolites
into
toxic
reactive
oxygen
species
(ROS)
situ,
thereby
inducing
oxidative
stress
promoting
cell
death.
However,
within
the
complex
tumor
microenvironment
(TME),
rational
design
of
nanozymes
factors
like
activity,
reaction
substrates,
TME
itself
significantly
influence
efficiency
ROS
generation.
To
address
these
limitations,
recent
research
has
focused
on
exploring
that
affect
activity
developing
nanozyme-based
cascade
systems,
which
can
trigger
two
or
more
processes
tumors,
producing
therapeutic
achieving
efficient
stable
with
minimal
side
effects.
This
area
remarkable
progress.
Perspective
provides
a
comprehensive
overview
nanozymes,
covering
their
classification
fundamentals.
The
regulation
nanozyme
strategies
are
discussed
detail.
Furthermore,
representative
paradigms
for
successful
construction
systems
treatment
summarized
focus
revealing
underlying
mechanisms.
Finally,
we
current
challenges
future
prospects
development
biomedical
applications.
Abstract
Photodynamic
therapy
(PDT)
has
significant
potential
in
the
treatment
of
dermatological,
oncological,
and
nonneoplastic
conditions
through
induction
cell
death,
immune
regulation,
antimicrobial
effects,
etc.
However,
response
some
patients
is
unsatisfactory,
there
a
lack
an
ideal
protocol
for
multiple
specific
diseases
(subtypes)
to
choose
proper
photosensitizer
(PS),
light
source,
dose.
A
thorough
understanding
underlying
mechanism
integral
solving
these
problems,
death
gained
much
attention.
In
addition
apoptosis,
autophagy,
necrosis,
several
novel
pathways,
such
as
necroptosis,
mitotic
catastrophe,
paraptosis
pyroptosis,
have
been
reported
PDT
treatment.
The
type
induced
depends
on
dose
PDT,
subcellular
location
PSs,
regulation
signaling
pathways.
addition,
different
types
by
same
apoptosis
may
interact
with
each
other.
Some
can
also
trigger
immunogenic
(ICD),
which
ignite
against
antigens
derived
from
dying/dead
cells
present
improved
antitumor
effects.
On
basis
mechanisms,
strategies,
targeted
combined
immunotherapy
ICD‐based
vaccines,
proposed
improve
therapeutic
efficacy.
Future
studies
are
needed
elucidate
relationship
between
effects
shed
new
exploration
precise
patients.
Cell Proliferation,
Год журнала:
2024,
Номер
57(8)
Опубликована: Март 10, 2024
Abstract
Mesenchymal
stem
cell‐derived
exosomes
(MSC‐Exo)
offer
promising
therapeutic
potential
for
various
refractory
diseases,
presenting
a
novel
strategy.
However,
their
clinical
application
encounters
several
obstacles,
including
low
natural
secretion,
uncontrolled
biological
functions
and
inherent
heterogeneity.
On
the
one
hand,
physical
stimuli
can
mimic
microenvironment
dynamics
where
MSC‐Exo
reside.
These
factors
influence
not
only
secretion
but
also,
significantly,
efficacy.
Moreover,
also
serve
as
techniques
engineering
exosomes.
Therefore,
realm
of
assumes
crucial
role
in
modifying
MSC‐Exo,
ultimately
facilitating
translation.
This
review
focuses
on
research
progress
applying
to
encompassing
ultrasound,
electrical
stimulation,
light
irradiation,
intrinsic
properties,
ionizing
radiation,
magnetic
field,
mechanical
forces
temperature.
We
discuss
current
status
stimuli‐affected
applications.
Furthermore,
we
address
limitations
recent
studies
this
field.
Based
this,
provides
insights
advance
refinement
approach
regenerative
medicine.
Chemical Science,
Год журнала:
2024,
Номер
15(18), С. 6752 - 6762
Опубликована: Янв. 1, 2024
A
mitochondria-localizing
iridium(
iii
)
photosensitizer
produces
singlet
oxygen
and
superoxide
anion
radicals
upon
two-photon
irradiation,
disrupting
the
mitochondrial
respiratory
chain
inducing
ferritinophagy
immunogenic
cell
death.
Inorganic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(17), С. 5435 - 5448
Опубликована: Янв. 1, 2024
Coumarin
6
appended
Ir(
iii
)
photocatalysts
exhibited
light
activated
anticancer
effects
against
cancer
cells
via
mitochondrial
depolarization
driven
apoptosis
by
inducing
type-I
(NADH
oxidation)
and
type-II
(ROS
generation)
mechanisms.
