Stimuli-activatable nanomedicine meets cancer theranostics

Theranostics, Год журнала: 2023, Номер 13(15), С. 5386 - 5417

Опубликована: Янв. 1, 2023

Stimuli-activatable strategies prevail in the design of nanomedicine for cancer theranostics.Upon exposure to endogenous/exogenous stimuli, stimuli-activatable could be self-assembled, disassembled, or functionally activated improve its biosafety and diagnostic/therapeutic potency.A myriad tumor-specific features, including a low pH, high redox level, overexpressed enzymes, along with exogenous physical stimulation sources (light, ultrasound, magnet, radiation) have been considered nano-medicinal products.Recently, novel stimuli explored elegant designs emerged nanomedicine.In addition, multi-functional theranostic has employed imaging-guided image-assisted antitumor therapy.In this review, we rationalize development clinical pressing needs.Stimuli-activatable self-assembly, disassembly functional activation approaches developing realize better efficacy are elaborated state-of-the-art advances their structural detailed.A reflection, status, future perspectives provided.

Язык: Английский

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Stimuli-responsive peptide assemblies: Design, self-assembly, modulation, and biomedical applications

Bioactive Materials, Год журнала: 2024, Номер 35, С. 181 - 207

Опубликована: Фев. 2, 2024

Peptide molecules have design flexibility, self-assembly ability, high biocompatibility, good biodegradability, and easy functionalization, which promote their applications as versatile biomaterials for tissue engineering biomedicine. In addition, the functionalization of self-assembled peptide nanomaterials with other additive components enhances stimuli-responsive functions, promoting function-specific that induced by both internal external stimulations. this review, we demonstrate recent advance in molecular design, self-assembly, functional tailoring, biomedical peptide-based nanomaterials. The strategies on synthesis single, dual, multiple various dimensions are analyzed, regulation active such metal/metal oxide, DNA/RNA, polysaccharides, photosensitizers, 2D materials, others discussed. designed temperature-, pH-, ion-, light-, enzyme-, ROS-responsive abilities drug delivery, bioimaging, cancer therapy, gene antibacterial, well wound healing dressing presented This comprehensive review provides detailed methodologies advanced techniques from biology, materials science, nanotechnology, will guide inspire level peptides specific functions applications.

Язык: Английский

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A comprehensive review on peptide-bearing biomaterials: From ex situ to in situ self-assembly

Coordination Chemistry Reviews, Год журнала: 2023, Номер 502, С. 215600 - 215600

Опубликована: Дек. 14, 2023

Язык: Английский

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Stimuli‐Responsive Prodrug Chemistries for Cancer Therapy

ChemBioChem, Год журнала: 2023, Номер 24(18)

Опубликована: Июнь 21, 2023

Abstract Prodrugs are pharmacologically inactive, chemically modified derivatives of active drugs, which, following in vivo administration, converted to the parent drugs through chemical or enzymatic cleavage. The prodrug approach holds tremendous potential create enhanced version an existing pharmacological agent and leverage those improvements augment drug molecules′ bioavailability, targeting ability, therapeutic efficacy, safety, marketability. Especially cancer therapy, application has received substantial attention. A can effectively broaden window its by enhancing release at targeted tumor sites while reducing access healthy cells. spatiotemporally controlled be achieved manipulating chemical, physical, biological stimuli present site. critical strategy comprises drug‐carrier linkages that respond physiological biochemical milieu yield form. This review will focus on recent advancements development various fluorophore‐drug conjugates widely used for real‐time monitoring delivery. use different stimuli‐cleavable linkers mechanisms linker cleavage discussed. Finally, conclude with a discussion prospects challenges might impede future such prodrugs.

Язык: Английский

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Smart down/upconversion nanomachines integrated with “AND” logic computation and enzyme-free amplification for NIR-II fluorescence-assisted precise and enhanced photodynamic therapy

Chemical Science, Год журнала: 2023, Номер 14(11), С. 3070 - 3075

Опубликована: Янв. 1, 2023

Upconversion nanoparticles enable indirect activation of photodynamic therapy (PDT) using near-infrared (NIR) light, providing an excellent alternative for treating deep tumors. However, conventional NIR light-triggered PDT systems suffered from low spatiotemporal accuracy and restricted therapeutic efficiency in vivo. In this work, DNA logic circuits were functionally modified on down/upconversion (D/UCNPs) to construct smart nanomachines (D/UCNMs) toward target Upon dual inputs tumor-associated GSH TK1 mRNA, perform "AND" computation initiate the toehold-mediated strand displacement reaction. Meanwhile, quenched upconversion fluorescence was recovered then approaching photosensitizers activated, leading situ output singlet oxygen (1O2) precise enhanced PDT. Importantly, biodistribution D/UCNMs vivo could be visualized by second (NIR-II) imaging via downconversion luminance D/UCNPs, which further contributed performing This work provides new insights into development highly efficient systems.

Язык: Английский

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Advances in Light-Responsive Smart Multifunctional Nanofibers: Implications for Targeted Drug Delivery and Cancer Therapy

Pharmaceutics, Год журнала: 2024, Номер 16(8), С. 1017 - 1017

Опубликована: Июль 31, 2024

Over the last decade, scientists have shifted their focus to development of smart carriers for delivery chemotherapeutics in order overcome problems associated with traditional chemotherapy, such as poor aqueous solubility and bioavailability, low selectivity targeting specificity, off-target drug side effects, damage surrounding healthy tissues. Nanofiber-based systems recently emerged a promising system cancer therapy owing unique structural functional properties, including tunable interconnected porosity, high surface-to-volume ratio entrapment efficiency loading capacity, mass transport which allow controlled targeted delivery. In addition, they are biocompatible, biodegradable, capable surface functionalization, allowing target-specific release. One most common fiber production methods is electrospinning, even though relatively two-dimensional (2D) tightly packed structures rates limited its performance. Forcespinning an alternative spinning technology that generates high-throughput, continuous polymeric nanofibers 3D structures. Unlike forcespinning fibers by centrifugal forces rather than electrostatic forces, resulting significantly higher production. The functionalization nanocarriers on can result anticancer capabilities be activated external stimuli, light. This review addresses current trends potential applications light-responsive dual-stimuli-responsive electro- forcespun therapy, particular emphasis functionalizing nanofiber surfaces developing nano-in-nanofiber emerging dual-controlled release high-precision tumor targeting. progress prospective diagnostic therapeutic discussed context combination therapy.

Язык: Английский

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Enzyme‐Directed and Organelle‐Specific Sphere‐to‐Fiber Nanotransformation Enhances Photodynamic Therapy in Cancer Cells

Small Methods, Год журнала: 2024, Номер 8(11)

Опубликована: Фев. 19, 2024

Abstract Employing responsive nanoplatforms as carriers for photosensitizers represents an effective strategy to overcome the challenges associated with photodynamic therapy (PDT), including poor solubility, low bioavailability, and high systemic toxicity. Drawing inspiration from morphology transitions in biological systems, a general approach enhance PDT that utilizes enzyme‐responsive is developed. The transformation of phosphopeptide/photosensitizer co‐assembled nanoparticles first demonstrated into nanofibers when exposed cytoplasmic enzyme alkaline phosphatase. This transition primarily driven by phosphatase‐induced changes hydrophilic hydrophobic balance, intermolecular electrostatic interactions within nanoparticles. resulting exhibit improved ability generating reactive oxygen species (ROS), intracellular accumulation, retention cancer cells. Furthermore, nanoplatform expanded selectively target mitochondria mitochondria‐specific sirtuin 5 (SIRT5). Under catalysis SIRT5, succinylated peptide/photosensitizer can be transformed specifically mitochondria. excellent capability modulating mitochondrial activity, enhanced ROS formation, significant anticancer efficacy via PDT. Consequently, enzyme‐instructed situ fibrillar peptide/photosensitizers provides efficient pathway address photosensitizers. It envisaged this will further expand toolbox biomaterials therapy.

Язык: Английский

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Twin-Tail Tadpole-Shaped Ce6-Peptide Conjugate for Enhanced Photodynamic Cancer Therapy

ACS Applied Bio Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 5, 2025

Despite its therapeutic potential, photodynamic therapy faces several key limitations in clinical applications, including poor drug delivery and insufficient tumor selectivity. We engineered RFYFYR-Ce6-RFYFYR (R-Ce6-R), a twin-tail peptide–photosensitizer conjugate that self-assembles into nanostructures for improved cancer treatment. By incorporating arginine-rich peptide sequences, this design not only enhances cellular internalization but also promotes peroxynitrite (ONOO–) formation, amplifying the effect. Our studies revealed R-Ce6-R achieves 33-fold higher potency than unmodified Ce6, with an IC50 of 0.18 μM. The demonstrated selective accumulation tissue, robust ROS generation, complete regression animal models while maintaining favorable safety profile. These results establish as innovative approach advancing

Язык: Английский

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Self-assembled porphyrin–peptide cages for photodynamic therapy

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(7), С. 1484 - 1494

Опубликована: Янв. 1, 2024

Dynamic covalent chemistry affords porphyrin–peptide cages which are found to be active photosensitizers for photodynamic therapy using green-light irradiation.

Язык: Английский

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Targeted pH-Activated Peptide-Based Nanomaterials for Combined Photodynamic Therapy with Immunotherapy

Biomacromolecules, Год журнала: 2024, Номер 25(5), С. 3044 - 3054

Опубликована: Апрель 25, 2024

Photodynamic therapy (PDT) has demonstrated efficacy in eliminating local tumors, yet its effectiveness against metastasis is constrained. While immunotherapy exhibited promise a clinical context, capacity to elicit significant systemic antitumor responses across diverse cancers often limited by the insufficient activation of host immune system. Consequently, combination PDT and garnered considerable attention. In this study, we developed pH-responsive porphyrin-peptide nanosheets with tumor-targeting capabilities (PRGD) that were loaded IDO inhibitor NLG919 for dual application involving (PRGD/NLG919). vitro experiments revealed heightened cellular uptake PRGD/NLG919 tumor cells overexpressing αvβ3 integrins. The remarkable singlet oxygen generation photocytotoxicity HeLa an acidic microenvironment. When treating followed laser irradiation, more robust adaptive response occurred, leading substantial proliferation CD3+CD8+ T CD3+CD4+ compared control groups. Our targeted therefore represent promising nanosystem therapy, offering effective enhanced response.

Язык: Английский

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