Biomedicines,
Год журнала:
2023,
Номер
11(8), С. 2146 - 2146
Опубликована: Июль 30, 2023
In
this
nanotechnology
era,
nanostructures
play
a
crucial
role
in
the
investigation
of
novel
functional
nanomaterials.
Complex
and
their
corresponding
fabrication
techniques
provide
powerful
tools
for
development
high-performance
materials.
study,
advanced
micro-nanomanufacturing
technologies
composite
micro-nanostructures
were
applied
to
new
type
pharmaceutical
formulation,
aiming
achieve
rapid
hemostasis,
pain
relief,
antimicrobial
properties.
Briefly,
an
approach
combining
electrohydrodynamic
atomization
(EHDA)
technique
reversed-phase
solvent
was
employed
fabricate
beaded
nanofiber
structure
(BNS),
consisting
micrometer-sized
particles
distributed
on
nanoscale
fiber
matrix.
Firstly,
Zein-loaded
Yunnan
Baiyao
(YB)
prepared
using
solution
electrospraying
process.
Subsequently,
these
suspended
co-solvent
containing
ciprofloxacin
(CIP)
hydrophilic
polymer
polyvinylpyrrolidone
(PVP)
electrospun
into
hybrid
structural
microfibers
handheld
electrospinning
device,
forming
EHDA
product
E3.
The
fiber-beaded
morphology
E3
confirmed
through
scanning
electron
microscopy
(SEM)
images.
Fourier-transform
infrared
(FTIR)
spectroscopy
X-ray
diffraction
(XRD)
analysis
revealed
amorphous
state
CIP
BNS
membrane
due
good
compatibility
between
PVP.
dissolution
experiment
that
exhibits
fast
disintegration
properties
promotes
CIP.
Moreover,
vitro
drug
release
study
demonstrated
complete
within
1
min.
Antibacterial
assays
showed
significant
reduction
number
adhered
bacteria
BNS,
indicating
excellent
antibacterial
performance.
Compared
with
traditional
YB
powders
Chinese
herbs,
series
advantages
potential
wound
dressing.
These
include
improved
effect,
sustained
active
ingredients
from
YB,
convenient
covering
application,
which
resulted
integration
herbs
Western
medicine.
This
provides
valuable
insights
multiscale
micro-/nano-composite
materials
pioneers
developments
types
medicines
combination
herbal
medicines.
Biomolecules,
Год журнала:
2023,
Номер
13(6), С. 1011 - 1011
Опубликована: Июнь 18, 2023
In
this
nano
era,
nanomaterials
and
nanostructures
are
popular
in
developing
novel
functional
materials.
However,
the
combinations
of
materials
at
micro
macro
scales
can
open
new
routes
for
trans-scale
products
with
improved
or
even
performances.
work,
a
brand-new
hybrid,
containing
both
nanofibers
microparticles,
was
fabricated
using
sequential
electrohydrodynamic
atomization
(EHDA)
process.
Firstly,
microparticles
loaded
drug
(berberine
hydrochloride,
BH)
molecules
cellulose
acetate
(CA)
were
solution
electrospraying
Later,
these
suspended
into
co-dissolved
that
contained
BH
hydrophilic
polymer
(polypyrrolidone,
PVP)
co-electrospun
nanofiber/microparticle
hybrids.
The
EHDA
processes
recorded,
resultant
showed
typical
hybrid
topography,
distributed
all
over
nanofibers,
which
demonstrated
by
SEM
assessments.
FTIR
XRD
components
within
hybrids
presented
an
amorphous
state
had
fine
compatibility
each
other.
vitro
dissolution
tests
verified
able
to
provide
designed
dual-step
release
profiles,
combination
fast
step
from
PVP
through
erosion
mechanism
sustained
insoluble
CA
via
Fickian
diffusion
mechanism.
present
protocols
pave
way
Chemosensors,
Год журнала:
2023,
Номер
11(4), С. 208 - 208
Опубликована: Март 25, 2023
Electrospun
nanofibers
have
shown
their
advantages
for
applications
in
a
wide
variety
of
scientific
fields
thanks
to
unique
properties.
Meanwhile,
electrospinning
is
closely
following
the
fast
development
nano
science
and
nanotechnology
move
forward
smaller
(pico-technology),
more
complicated
nanostructures/nanodevices
order
(all
kinds
arrays).
Particularly,
multiple-fluid
has
strong
capability
creating
nanostructures
from
structural
spinneret
single-step
straightforward
“top-down”
manner,
holding
great
promise
creation
on
large
scale.
This
review
just
conclude
state-of-art
studies
related
topics
also
point
out
that
future
directions
environmental
detection
require
chemosensors,
while
improvement
sensors
requires
new
chemically
synthesized
functional
substances,
nanostructured
materials,
application
convenience,
integration
or
synergy.
Based
developments
electrospinning,
possibilities
can
be
drawn
detecting
pollutants
with
electrospun
as
support
platform.
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
62(22)
Опубликована: Апрель 20, 2023
Inducing
high
levels
of
reactive
oxygen
species
(ROS)
inside
tumor
cells
is
a
cancer
therapy
method
termed
chemodynamic
(CDT).
Relying
on
delivery
Fenton
reaction
promoters
such
as
Fe
Polymers,
Год журнала:
2023,
Номер
15(10), С. 2237 - 2237
Опубликована: Май 9, 2023
Colon-targeted
drug
delivery
is
gradually
attracting
attention
because
it
can
effectively
treat
colon
diseases.
Furthermore,
electrospun
fibers
have
great
potential
application
value
in
the
field
of
their
unique
external
shape
and
internal
structure.
In
this
study,
a
core
layer
hydrophilic
polyethylene
oxide
(PEO)
anti-colon-cancer
curcumin
(CUR),
middle
ethanol,
sheath
natural
pH-sensitive
biomaterial
shellac
were
used
modified
triaxial
electrospinning
process
to
prepare
beads-on-the-string
(BOTS)
microfibers.
A
series
characterizations
carried
out
on
obtained
verify
process-shape/structure-application
relationship.
The
results
scanning
electron
microscopy
transmission
indicated
BOTS
core-sheath
X-ray
diffraction
that
was
an
amorphous
form.
Infrared
spectroscopy
revealed
good
compatibility
components
fibers.
vitro
release
microfibers
provide
colon-targeted
zero-order
release.
Compared
linear
cylindrical
microfibers,
prevent
leakage
drugs
simulated
gastric
fluid,
they
intestinal
fluid
beads
act
as
reservoirs.
Biomedicines,
Год журнала:
2023,
Номер
11(8), С. 2146 - 2146
Опубликована: Июль 30, 2023
In
this
nanotechnology
era,
nanostructures
play
a
crucial
role
in
the
investigation
of
novel
functional
nanomaterials.
Complex
and
their
corresponding
fabrication
techniques
provide
powerful
tools
for
development
high-performance
materials.
study,
advanced
micro-nanomanufacturing
technologies
composite
micro-nanostructures
were
applied
to
new
type
pharmaceutical
formulation,
aiming
achieve
rapid
hemostasis,
pain
relief,
antimicrobial
properties.
Briefly,
an
approach
combining
electrohydrodynamic
atomization
(EHDA)
technique
reversed-phase
solvent
was
employed
fabricate
beaded
nanofiber
structure
(BNS),
consisting
micrometer-sized
particles
distributed
on
nanoscale
fiber
matrix.
Firstly,
Zein-loaded
Yunnan
Baiyao
(YB)
prepared
using
solution
electrospraying
process.
Subsequently,
these
suspended
co-solvent
containing
ciprofloxacin
(CIP)
hydrophilic
polymer
polyvinylpyrrolidone
(PVP)
electrospun
into
hybrid
structural
microfibers
handheld
electrospinning
device,
forming
EHDA
product
E3.
The
fiber-beaded
morphology
E3
confirmed
through
scanning
electron
microscopy
(SEM)
images.
Fourier-transform
infrared
(FTIR)
spectroscopy
X-ray
diffraction
(XRD)
analysis
revealed
amorphous
state
CIP
BNS
membrane
due
good
compatibility
between
PVP.
dissolution
experiment
that
exhibits
fast
disintegration
properties
promotes
CIP.
Moreover,
vitro
drug
release
study
demonstrated
complete
within
1
min.
Antibacterial
assays
showed
significant
reduction
number
adhered
bacteria
BNS,
indicating
excellent
antibacterial
performance.
Compared
with
traditional
YB
powders
Chinese
herbs,
series
advantages
potential
wound
dressing.
These
include
improved
effect,
sustained
active
ingredients
from
YB,
convenient
covering
application,
which
resulted
integration
herbs
Western
medicine.
This
provides
valuable
insights
multiscale
micro-/nano-composite
materials
pioneers
developments
types
medicines
combination
herbal
medicines.
