A Sequential Electrospinning of a Coaxial and Blending Process for Creating Double-Layer Hybrid Films to Sense Glucose DOI Creative Commons
Yutong Du,

Zili Yang,

Shixiong Kang

et al.

Sensors, Journal Year: 2023, Volume and Issue: 23(7), P. 3685 - 3685

Published: April 2, 2023

This study presents a glucose biosensor based on electrospun core-sheath nanofibers. Two types of film were fabricated using different electrospinning procedures. Film F1 was composed solely nanofibers modified coaxial process. F2 double-layer hybrid through sequential and blending The bottom layer comprised process, in which pure polymethacrylate type A (Eudragit L100) used as the core section water-soluble lignin (WSL) phenol loaded sheath section. top contained oxidase (GOx) gold nanoparticles, distributed throughout polyvinylpyrrolidone K90 (PVP K90) single-fluid investigated process detail. experimental results demonstrated that had higher degradation efficiency β-D-glucose than F1, reaching maximum over 70% after 12 h within concentration range 10-40 mmol/L. is for colorimetric sensing 1-15 solution exhibited color deepened gradually with an increase concentration. Electrospinning flexible creating structures bio-cascade reactions, can provide simple template developing other nanomaterials.

Language: Английский

Dual-Step Controlled Release of Berberine Hydrochloride from the Trans-Scale Hybrids of Nanofibers and Microparticles DOI Creative Commons
Jianfeng Zhou,

Yelin Dai,

Junhao Fu

et al.

Biomolecules, Journal Year: 2023, Volume and Issue: 13(6), P. 1011 - 1011

Published: June 18, 2023

In this nano era, nanomaterials and nanostructures are popular in developing novel functional materials. However, the combinations of materials at micro macro scales can open new routes for trans-scale products with improved or even performances. work, a brand-new hybrid, containing both nanofibers microparticles, was fabricated using sequential electrohydrodynamic atomization (EHDA) process. Firstly, microparticles loaded drug (berberine hydrochloride, BH) molecules cellulose acetate (CA) were solution electrospraying Later, these suspended into co-dissolved that contained BH hydrophilic polymer (polypyrrolidone, PVP) co-electrospun nanofiber/microparticle hybrids. The EHDA processes recorded, resultant showed typical hybrid topography, distributed all over nanofibers, which demonstrated by SEM assessments. FTIR XRD components within hybrids presented an amorphous state had fine compatibility each other. vitro dissolution tests verified able to provide designed dual-step release profiles, combination fast step from PVP through erosion mechanism sustained insoluble CA via Fickian diffusion mechanism. present protocols pave way

Language: Английский

Citations

37
Enzyme‐Triggered Chemodynamic Therapy via a Peptide‐H2S Donor Conjugate with Complexed Fe2+ DOI Creative Commons
Yumeng Zhu, William R. Archer,

Katlyn F. Morales

et al.

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(22)

Published: April 20, 2023

Inducing high levels of reactive oxygen species (ROS) inside tumor cells is a cancer therapy method termed chemodynamic (CDT). Relying on delivery Fenton reaction promoters such as Fe

Language: Английский

Citations

31
Engineered Shellac Beads-on-the-String Fibers Using Triaxial Electrospinning for Improved Colon-Targeted Drug Delivery DOI Open Access

Yaoyao Yang,

Wei Chen, Menglong Wang

et al.

Polymers, Journal Year: 2023, Volume and Issue: 15(10), P. 2237 - 2237

Published: May 9, 2023

Colon-targeted drug delivery is gradually attracting attention because it can effectively treat colon diseases. Furthermore, electrospun fibers have great potential application value in the field of their unique external shape and internal structure. In this study, a core layer hydrophilic polyethylene oxide (PEO) anti-colon-cancer curcumin (CUR), middle ethanol, sheath natural pH-sensitive biomaterial shellac were used modified triaxial electrospinning process to prepare beads-on-the-string (BOTS) microfibers. A series characterizations carried out on obtained verify process-shape/structure-application relationship. The results scanning electron microscopy transmission indicated BOTS core-sheath X-ray diffraction that was an amorphous form. Infrared spectroscopy revealed good compatibility components fibers. vitro release microfibers provide colon-targeted zero-order release. Compared linear cylindrical microfibers, prevent leakage drugs simulated gastric fluid, they intestinal fluid beads act as reservoirs.

Language: Английский

Citations

27
Integrating Chinese Herbs and Western Medicine for New Wound Dressings through Handheld Electrospinning DOI Creative Commons
Jianfeng Zhou,

Liangzhe Wang,

Wenjian Gong

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(8), P. 2146 - 2146

Published: July 30, 2023

In this nanotechnology era, nanostructures play a crucial role in the investigation of novel functional nanomaterials. Complex and their corresponding fabrication techniques provide powerful tools for development high-performance materials. study, advanced micro-nanomanufacturing technologies composite micro-nanostructures were applied to new type pharmaceutical formulation, aiming achieve rapid hemostasis, pain relief, antimicrobial properties. Briefly, an approach combining electrohydrodynamic atomization (EHDA) technique reversed-phase solvent was employed fabricate beaded nanofiber structure (BNS), consisting micrometer-sized particles distributed on nanoscale fiber matrix. Firstly, Zein-loaded Yunnan Baiyao (YB) prepared using solution electrospraying process. Subsequently, these suspended co-solvent containing ciprofloxacin (CIP) hydrophilic polymer polyvinylpyrrolidone (PVP) electrospun into hybrid structural microfibers handheld electrospinning device, forming EHDA product E3. The fiber-beaded morphology E3 confirmed through scanning electron microscopy (SEM) images. Fourier-transform infrared (FTIR) spectroscopy X-ray diffraction (XRD) analysis revealed amorphous state CIP BNS membrane due good compatibility between PVP. dissolution experiment that exhibits fast disintegration properties promotes CIP. Moreover, vitro drug release study demonstrated complete within 1 min. Antibacterial assays showed significant reduction number adhered bacteria BNS, indicating excellent antibacterial performance. Compared with traditional YB powders Chinese herbs, series advantages potential wound dressing. These include improved effect, sustained active ingredients from YB, convenient covering application, which resulted integration herbs Western medicine. This provides valuable insights multiscale micro-/nano-composite materials pioneers developments types medicines combination herbal medicines.

Language: Английский

Citations

27
A Sequential Electrospinning of a Coaxial and Blending Process for Creating Double-Layer Hybrid Films to Sense Glucose DOI Creative Commons
Yutong Du,

Zili Yang,

Shixiong Kang

et al.

Sensors, Journal Year: 2023, Volume and Issue: 23(7), P. 3685 - 3685

Published: April 2, 2023

This study presents a glucose biosensor based on electrospun core-sheath nanofibers. Two types of film were fabricated using different electrospinning procedures. Film F1 was composed solely nanofibers modified coaxial process. F2 double-layer hybrid through sequential and blending The bottom layer comprised process, in which pure polymethacrylate type A (Eudragit L100) used as the core section water-soluble lignin (WSL) phenol loaded sheath section. top contained oxidase (GOx) gold nanoparticles, distributed throughout polyvinylpyrrolidone K90 (PVP K90) single-fluid investigated process detail. experimental results demonstrated that had higher degradation efficiency β-D-glucose than F1, reaching maximum over 70% after 12 h within concentration range 10-40 mmol/L. is for colorimetric sensing 1-15 solution exhibited color deepened gradually with an increase concentration. Electrospinning flexible creating structures bio-cascade reactions, can provide simple template developing other nanomaterials.

Language: Английский

Citations

23