Transactions of Tianjin University, Год журнала: 2023, Номер 29(4), С. 254 - 274
Опубликована: Июль 3, 2023
Язык: Английский
Nature Communications, Год журнала: 2024, Номер 15(1)
Опубликована: Май 7, 2024
Herein, we develop a straightforward, metal-free, and acid-/base-free electrochemical C4-selective C - H deuteration of pyridine derivatives with economic convenient D
Язык: Английский
Процитировано
15
Chinese Journal of Chemistry, Год журнала: 2024, Номер 42(18), С. 2249 - 2266
Опубликована: Май 15, 2024
Comprehensive Summary CO 2 is an abundant, nontoxic, and renewable C1 feedstock in synthetic chemistry. Direct carboxylation of readily available olefins incorporating regarded as a promising strategy to access high value‐added carboxylic acids well fixation. However, due the thermodynamic stability kinetic inertness difficulty controlling regioselectivity, with still remains challenging. Radical‐type functionalization represented powerful protocol enabled development novel transformations this realm. More recently, advance new technology, such photoredox catalysis renaissance electrochemistry organic synthesis, offered unique chemical reactivities radical precursors provided solutions olefins. This review presents recent advances radical‐type olefins, which has mainly been achieved through photocatalysis electrocatalysis last decade. In article, we provide comprehensive introduction progress, summarize advantages limitations current research, discuss potential outlook for further development. Key Scientists
Язык: Английский
Процитировано
15
ACS Catalysis, Год журнала: 2024, Номер 14(3), С. 1459 - 1467
Опубликована: Янв. 13, 2024
Electrochemical carboxylation of 1,3-dienes with carbon dioxide (CO2) is a feasible method to obtain dicarboxylic derivatives, which are important synthetic intermediates polymers and pharmaceuticals. However, due unavoidable byproducts unfriendly conditions, the formation pure acids has been limited. In this work, we report that bimetallic phosphating CoFeP catalyst on nickel foam (CoFeP/NF) served as remarkable electrode, transforms CO2 into multicarbon (C6+) acids. The synergistic effects between Co Fe allow activation mainly, in electron transfer easier proceeded afford radical anion diene, pursuant further formed ultimate carboxylated products. reaction can occur commercial flow cell gram-scale amplification. acid obtained was up 1.08 g at 5 mmol scale 1,3-dienes, illustrating high electrocatalytic activity practical application CoFeP/NF.
Язык: Английский
Процитировано
12
Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(13)
Опубликована: Фев. 3, 2024
Abstract Pyridine motifs are widespread pharmacophores in many drugs. Installing various substituents through pyridine C−H bond functionalization is significant for new drug design and discovery. Developments of late‐stage reactions enrich the strategies selective pyridines. However, carboxylation pyridines a long‐standing challenge, especially selectively with CO 2 on motifs. Herein, we describe practical method C4−H via one‐pot phosphination copper‐catalyzed resulted phosphonium salts . The reaction conducted under mild conditions compatible multiple active groups several drugs, providing diverse valuable isonicotinic acid compounds, demonstrating application potential this strategy.
Язык: Английский
Процитировано
11
Science China Chemistry, Год журнала: 2024, Номер 67(10), С. 3366 - 3372
Опубликована: Авг. 16, 2024
Язык: Английский
Процитировано
10
Chemical Communications, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
In this study, a straightforward and environmentally benign electrochemical mono-functionalization of alkenes has been established for the synthesis alkenyl selenium sulfonates using elemental as source.
Язык: Английский
Процитировано
1
Chemical Society Reviews, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
This review highlights organo-mediators that enable electrochemical reactions via outer-sphere electron transfer (ET), offering advantages such as availability, tunability, and simplified post-processing compared to direct electrolysis.
Язык: Английский
Процитировано
1
Nature Communications, Год журнала: 2023, Номер 14(1)
Опубликована: Окт. 13, 2023
Herein, a metal-free electrochemical dihydroxylation of unactivated alkenes is described. The transformation proceeds smoothly under mild conditions with broad range alkenes, providing valuable and versatile dihydroxylated products in moderate to good yields without the addition costly transition metals stoichiometric amounts chemical oxidants. Moreover, this method can be applied natural pharmaceutical derivatives, further demonstrating its synthetic utility. Mechanistic studies have revealed that iodohydrin epoxide intermediate are formed during reaction process.
Язык: Английский
Процитировано
22
Chemistry - A European Journal, Год журнала: 2023, Номер 29(36)
Опубликована: Апрель 18, 2023
Herein, a nickela-electrocatalyzed cross-electrophile coupling of readily available aryl aziridines and bromides under mild sustainable electrochemical conditions to access synthetic useful β-arylethylamines is developed. This protocol characterized by its exquisite chemo- regioselectivity, broad substrate scope good functional group compatibility. Mechanistic studies confirmed that the regioselectivity reactivity observed are result electro-induced ring-opening electroreductive generate benzyl radical intermediate as active species. Furthermore, this strategy also enables cross-coupling with CO2 β-amino acids conditions.
Язык: Английский
Процитировано
18
Science China Chemistry, Год журнала: 2024, Номер 67(10), С. 3223 - 3246
Опубликована: Июль 9, 2024
Язык: Английский
Процитировано
7