Transactions of Tianjin University, Journal Year: 2023, Volume and Issue: 29(4), P. 254 - 274
Published: July 3, 2023
Language: Английский
Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: May 7, 2024
Herein, we develop a straightforward, metal-free, and acid-/base-free electrochemical C4-selective C - H deuteration of pyridine derivatives with economic convenient D
Language: Английский
Citations
15
Chinese Journal of Chemistry, Journal Year: 2024, Volume and Issue: 42(18), P. 2249 - 2266
Published: May 15, 2024
Comprehensive Summary CO 2 is an abundant, nontoxic, and renewable C1 feedstock in synthetic chemistry. Direct carboxylation of readily available olefins incorporating regarded as a promising strategy to access high value‐added carboxylic acids well fixation. However, due the thermodynamic stability kinetic inertness difficulty controlling regioselectivity, with still remains challenging. Radical‐type functionalization represented powerful protocol enabled development novel transformations this realm. More recently, advance new technology, such photoredox catalysis renaissance electrochemistry organic synthesis, offered unique chemical reactivities radical precursors provided solutions olefins. This review presents recent advances radical‐type olefins, which has mainly been achieved through photocatalysis electrocatalysis last decade. In article, we provide comprehensive introduction progress, summarize advantages limitations current research, discuss potential outlook for further development. Key Scientists
Language: Английский
Citations
15
ACS Catalysis, Journal Year: 2024, Volume and Issue: 14(3), P. 1459 - 1467
Published: Jan. 13, 2024
Electrochemical carboxylation of 1,3-dienes with carbon dioxide (CO2) is a feasible method to obtain dicarboxylic derivatives, which are important synthetic intermediates polymers and pharmaceuticals. However, due unavoidable byproducts unfriendly conditions, the formation pure acids has been limited. In this work, we report that bimetallic phosphating CoFeP catalyst on nickel foam (CoFeP/NF) served as remarkable electrode, transforms CO2 into multicarbon (C6+) acids. The synergistic effects between Co Fe allow activation mainly, in electron transfer easier proceeded afford radical anion diene, pursuant further formed ultimate carboxylated products. reaction can occur commercial flow cell gram-scale amplification. acid obtained was up 1.08 g at 5 mmol scale 1,3-dienes, illustrating high electrocatalytic activity practical application CoFeP/NF.
Language: Английский
Citations
12
Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(13)
Published: Feb. 3, 2024
Abstract Pyridine motifs are widespread pharmacophores in many drugs. Installing various substituents through pyridine C−H bond functionalization is significant for new drug design and discovery. Developments of late‐stage reactions enrich the strategies selective pyridines. However, carboxylation pyridines a long‐standing challenge, especially selectively with CO 2 on motifs. Herein, we describe practical method C4−H via one‐pot phosphination copper‐catalyzed resulted phosphonium salts . The reaction conducted under mild conditions compatible multiple active groups several drugs, providing diverse valuable isonicotinic acid compounds, demonstrating application potential this strategy.
Language: Английский
Citations
11
Science China Chemistry, Journal Year: 2024, Volume and Issue: 67(10), P. 3366 - 3372
Published: Aug. 16, 2024
Language: Английский
Citations
10
Chemical Communications, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
In this study, a straightforward and environmentally benign electrochemical mono-functionalization of alkenes has been established for the synthesis alkenyl selenium sulfonates using elemental as source.
Language: Английский
Citations
1
Chemical Society Reviews, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
This review highlights organo-mediators that enable electrochemical reactions via outer-sphere electron transfer (ET), offering advantages such as availability, tunability, and simplified post-processing compared to direct electrolysis.
Language: Английский
Citations
1
Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)
Published: Oct. 13, 2023
Herein, a metal-free electrochemical dihydroxylation of unactivated alkenes is described. The transformation proceeds smoothly under mild conditions with broad range alkenes, providing valuable and versatile dihydroxylated products in moderate to good yields without the addition costly transition metals stoichiometric amounts chemical oxidants. Moreover, this method can be applied natural pharmaceutical derivatives, further demonstrating its synthetic utility. Mechanistic studies have revealed that iodohydrin epoxide intermediate are formed during reaction process.
Language: Английский
Citations
22
Chemistry - A European Journal, Journal Year: 2023, Volume and Issue: 29(36)
Published: April 18, 2023
Herein, a nickela-electrocatalyzed cross-electrophile coupling of readily available aryl aziridines and bromides under mild sustainable electrochemical conditions to access synthetic useful β-arylethylamines is developed. This protocol characterized by its exquisite chemo- regioselectivity, broad substrate scope good functional group compatibility. Mechanistic studies confirmed that the regioselectivity reactivity observed are result electro-induced ring-opening electroreductive generate benzyl radical intermediate as active species. Furthermore, this strategy also enables cross-coupling with CO2 β-amino acids conditions.
Language: Английский
Citations
18
Science China Chemistry, Journal Year: 2024, Volume and Issue: 67(10), P. 3223 - 3246
Published: July 9, 2024
Language: Английский
Citations
7