Catalyst-Controlled Divergent Cyclopropene Hydroselenation

ACS Catalysis, Год журнала: 2025, Номер unknown, С. 8855 - 8864

Опубликована: Май 11, 2025

Язык: Английский

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Chiral PCN pincer Ni(ii) complex-catalyzed asymmetric hydrophosphination of 2-alkenoylpyridines with diphenylphosphine

RSC Advances, Год журнала: 2025, Номер 15(20), С. 15904 - 15918

Опубликована: Янв. 1, 2025

Eleven chiral PCN pincer Ni( ii ) complexes were successfully synthesized and characterized. One of them served as an effective stereoselective catalyst for the asymmetric hydrophosphination 2-alkenoylpyridines with diphenylphosphine.

Язык: Английский

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Synthesis of chiral difluoromethyl cyclopropanes through desymmetric difluoromethylation of cyclopropenes enabled by enantioselective copper catalysis

Nature Synthesis, Год журнала: 2025, Номер unknown

Опубликована: Май 22, 2025

Язык: Английский

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Lewis Acid-Mediated Deoxygenative Synthesis of Trivalent Sterically Hindered Phosphines from Aldehydes

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Май 29, 2025

The efficient synthesis of trisubstituted trivalent phosphines remains challenging. Herein, we report a novel approach for rapid construction these compounds from aldehydes under Lewis acid-mediated conditions. By using sterically hindered disubstituted phosphines, can undergo deoxygenative reaction to afford phosphorus compounds. This modular and practical method is characterized by operational simplicity, broad substrate scope, excellent functional group tolerance, which holds great potential applications in organic synthesis.

Язык: Английский

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A Remarkable Catalyst-Free Photochemical Alkene Hydrophosphination with Bis(trimethylsilyl)phosphonite

JACS Au, Год журнала: 2025, Номер unknown

Опубликована: Июнь 3, 2025

Язык: Английский

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Recent Advances in Transition Metal‐Catalyzed Asymmetric Synthesis of P‐chiral Organophosphorus Compounds (2020–Present)

Chinese Journal of Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Июнь 3, 2025

Comprehensive Summary P ‐chiral organophosphorus compounds have demonstrated unparalleled application potential in diverse fields, including medicine, agricultural science, material and life science. Furthermore, they serve as highly effective chiral ligands both transition metal‐catalyzed organocatalytic asymmetric transformations. In recent years, significant advances been made the catalytic synthesis of compounds, with phosphination hydrophosphination reactions emerging dominant strategies. This review systematically summarizes methodological developments from 2020 to present for constructing compounds. The discussion is organized according different metals, aiming provide a valuable reference inspiration researchers organic chemistry. Key Scientists

Язык: Английский

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Cobalt- or rhodium-catalyzed synthesis of 1,2-dihydrophosphete oxides via C–H activation and formal phosphoryl migration

Chemical Science, Год журнала: 2024, Номер 15(16), С. 6012 - 6021

Опубликована: Янв. 1, 2024

A highly stereo- and chemoselective intermolecular coupling of diverse heterocycles with dialkynylphosphine oxides has been realized

Язык: Английский

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Synthetic Versatility: The C-P Bond Odyssey

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 15, 2024

The review thoroughly examines recent progress in C–P bond formation reactions and considers the future directions this area of research.

Язык: Английский

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Diastereoselective and Enantioselective Hydrophosphinylations of Conjugated Enynes, Allenes and Dienes via Synergistic Pd/Co Catalysis

Angewandte Chemie, Год журнала: 2024, Номер 137(1)

Опубликована: Сен. 10, 2024

Abstract Different from the reported work focusing on construction of single P ‐ or C ‐stereocenter via hydrophosphinylation unsaturated carbon bonds, highly diastereo‐ and enantioselective reaction allenes, conjugated enynes 1,3‐dienes is achieved a designed Pd/Co dual catalysis newly modified masked phosphinylating reagent. A series allyl motifs bearing both tertiary are prepared in generally good yields, >20 : 1 dr, rr 99 % ee. The unprecedented 1,3‐enynes established to generate skeletons containing nonadjacent chiral axis. first stereodivergent also developed achieve all four ‐containing stereoisomers. present protocol features use only 3‐minutes time 0.1 catalyst, with observation up 730 TON. set mechanistic studies reveal necessity roles two metal catalysts corroborate synergistic process.

Язык: Английский

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Copper(I)‐Catalyzed Asymmetric 1,4‐Hydroarsination of α,β‐Unsaturated Compounds

Angewandte Chemie International Edition, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 18, 2024

Abstract Herein, a copper(I)‐catalyzed asymmetric 1,4‐hydroarsination of β‐substituted α,β‐unsaturated esters is achieved in moderate to excellent yields with high enantioselectivity, based on the proposed nucleophilic [Cu]−AsPh 2 species. As for α‐substituted esters, 1,4‐hydroarsination/enantioselective protonation event occurs smoothly satisfying results. Furthermore, ketone, amide, and phosphine sulfide are well applied present catalytic system. Finally, some control experiments show that HAsPh activated through coordination copper(I) catalyst exhibits inferior soft Lewis basicity HPPh presence copper(I)‐bisphosphine complex.

Язык: Английский

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