Fluorinated Titanium Oxide (TiO_2–xF_x) Nanospindles as Ultrasound-Triggered Pyroptosis Inducers to Boost Sonodynamic Immunotherapy

ACS Nano, Год журнала: 2024, Номер unknown

Опубликована: Июль 15, 2024

Pyroptosis is an inflammatory form of programmed cell death associated with the immune system that can be induced by reactive oxygen species (ROS). As a therapeutic strategy better penetration depth, sonodynamic therapy (SDT) expected to induce pyroptosis cancer cells and boost response. However, it still limited problem precisely adjust structure sonosensitizers exhibit satisfactory sono-catalytic properties. Herein, fluorinated titanium oxide (TiO2–xFx) were developed under ultrasound (US) antitumor responses, enabling highly effective SDT. On one hand, introduction F atoms significantly reduced adsorption energy TiO2–xFx for water, which conducive occurrence reactions. other process replacing O increased vacancies sonosensitizer shortened band gap, enabled powerful ROS generation ability US stimulation. In this case, large amounts could effectively kill inducing mitochondrial damage disrupting oxidative homeostasis, leading significant pyroptosis. Moreover, SDT treatment not only suppressed tumor proliferation but also elicited robust memory effects hindered recurrence. This work highlighted importance regulating achieve efficient pyroptosis, sets stage further development SDT-immunotherapy.

Язык: Английский

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Half‐metallization Atom‐Fingerprints Achieved at Ultrafast Oxygen‐Evaporated Pyrochlores for Acidic Water Oxidation

Advanced Materials, Год журнала: 2024, Номер unknown

Опубликована: Авг. 9, 2024

The stability and catalytic activity of acidic oxygen evolution reaction (OER) are strongly determined by the coordination states spatial symmetry among metal sites at catalysts. Herein, an ultrafast evaporation technology to rapidly soften intrinsic covalent bonds using ultrahigh electrical pulses is suggested, in which prospective charged excited this extreme avalanche condition can generate a strong electron-phonon coupling evaporate some coordinated (O) atoms, finally leading controllable half-metallization feature. Simultaneously, relative (M) site arrays be orderly locked delineate intriguing atom-fingerprints pyrochlore catalysts, where coexistence metallic (M─M) (M─O) symmetry-breaking configuration partially restrain crystal field effect particular high-spin occupied state. This catalyst effectively optimize spin-related kinetics OER, giving rise 10.3 times (at 188 mV overpotential) reactive than pristine pyrochlores. work provides new understanding surfaces accelerate water oxidation.

Язык: Английский

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Integrating Interactive Ir Atoms into Titanium Oxide Lattice for Proton Exchange Membrane Electrolysis

Advanced Materials, Год журнала: 2024, Номер unknown

Опубликована: Дек. 2, 2024

Abstract Iridium (Ir)‐based oxide is the state‐of‐the‐art electrocatalyst for acidic water oxidation, yet it restricted to a few Ir‐O octahedral packing modes with limited structural flexibility. Herein, geometric structure diversification of Ir achieved by integrating spatially correlated atoms into surface lattice TiO 2 and its booting effect on oxygen evolution reaction (OER) investigated. Notably, resultant i ‐Ir/TiO catalyst exhibits much higher electrocatalytic activity, an overpotential 240 mV at 10 mA cm −2 excellent stability 315 h 100 in electrolyte. Both experimental theoretical findings reveal that flexible Ir─O─Ir coordination varied plays crucial role enhancing OER which optimize intermediate adsorption adjusting d ‐band center active sites. Operando characterizations demonstrate interactive units can suppress over‐oxidation Ir, effectively widening stable region species during catalytic process. The proton exchange membrane (PEM) electrolyzer, equipped as anode, gives low driving voltage 1.63 V A maintains performance over 440 h. This work presents general strategy eliminate inherent limitations IrO x species, thereby inspiring further development advanced designs.

Язык: Английский

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A Multifaceted Synthesis Strategy to Modulate the Hydrophilicity and Electrical Conductivity of Cofs to Improve Oer Performance

Опубликована: Янв. 1, 2025

Язык: Английский

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Asymmetric spin exchange interaction induced by orderly bimetal atomic-hybridization optimizes nitrate reduction electrocatalysis

Surfaces and Interfaces, Год журнала: 2025, Номер unknown, С. 106078 - 106078

Опубликована: Фев. 1, 2025

Язык: Английский

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Recent advances and challenges in single-atom catalysts for proton exchange membrane water electrolysis

Next Materials, Год журнала: 2025, Номер 8, С. 100553 - 100553

Опубликована: Фев. 21, 2025

Язык: Английский

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Site-specific stabilizing effect of single atoms on spinel oxides for acidic oxygen evolution

eScience, Год журнала: 2025, Номер unknown, С. 100402 - 100402

Опубликована: Март 1, 2025

Язык: Английский

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Innovative single atom arrays for the electrocatalytic reaction

Science China Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 2, 2025

Язык: Английский

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Engineering the regulation strategy of active sites to explore the intrinsic mechanism over single‑atom catalysts in electrocatalysis

Journal of Colloid and Interface Science, Год журнала: 2025, Номер 693, С. 137595 - 137595

Опубликована: Апрель 14, 2025

Язык: Английский

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Rapid carrier extraction and d-band center regulation of Pd-ZnIn2S4 for efficient photocatalytic water splitting

Journal of Alloys and Compounds, Год журнала: 2025, Номер unknown, С. 180652 - 180652

Опубликована: Апрель 1, 2025

Язык: Английский

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