Highly Diastereo- and Enantioselective Synthesis of Chiral Cyclohexylphosphines by Cu-Catalyzed Phosphination-Aldol Cyclization of Ketone-Enamides

Organic Letters, Год журнала: 2023, Номер 26(1), С. 210 - 214

Опубликована: Дек. 21, 2023

A highly diastereo- and enantioselective phosphinative cyclization of ketone-enamides with secondary diarylphosphines enabled by copper catalysis is reported, providing a range chiral tertiary cyclohexylphosphines bearing three contiguous stereogenic centers in high yields. This asymmetric phosphination-aldol protocol can also be extended to desymmetrization dione-enamides create four selective manner.

Язык: Английский

---

Copper(I)‐Catalyzed Asymmetric Hydrophosphination of 3,3‐Disubstituted Cyclopropenes

Angewandte Chemie, Год журнала: 2023, Номер 135(40)

Опубликована: Авг. 18, 2023

Abstract Herein, a copper(I)‐catalyzed asymmetric hydrophosphination of 3,3‐disubstituted cyclopropenes is reported. It provides series phosphine derivatives in high to excellent diastereo‐ and enantioselectivities. The methodology enjoys broad substrate scope on both diarylphosphines. stereoselectivity attributed the stability Cu(I)‐( R , )‐QUINOXP* complex presence stoichiometric HPPh 2 produced phosphines, high‐performance induction complex. Finally, method used for synthesis new chiral phosphine‐olefin compounds built cyclopropane skeleton, one which serves as wonderful ligand Rh‐catalyzed conjugate addition phenylboronic acid various α,β‐unsaturated compounds.

Язык: Английский

---

Asymmetric Hydrophosphination of Cyclopropenes

Synfacts, Год журнала: 2023, Номер 19(11), С. 1120 - 1120

Опубликована: Окт. 14, 2023

Key words asymmetric catalysis - copper cyclopropenes hydrophospination lanthanocene

Язык: Английский

---