Remote Control of Energy Transformation‐Based Cancer Imaging and Therapy

Advanced Materials, Год журнала: 2024, Номер 36(27)

Опубликована: Март 29, 2024

Cancer treatment requires precise tumor-specific targeting at specific sites that allows for high-resolution diagnostic imaging and long-term patient-tailorable cancer therapy; while, minimizing side effects largely arising from non-targetability. This can be realized by harnessing exogenous remote stimuli, such as tissue-penetrative ultrasound, magnetic field, light, radiation, enable local activation therapy in deep tumors. A myriad of nanomedicines efficiently activated when the energy stimuli transformed into another type energy. review discusses control transformation targetable, efficient, therapy. Such ultrasonic, magnetic, photonic, radiative, radioactive mechanical, thermal, chemical, radiative to a variety modalities. The current article describes multimodal where serial cascade or multiple types occur. includes not only hyperthermia, radiation but also emerging thermoelectric, pyroelectric, piezoelectric therapies treatment. It illustrates resonance, fluorescence, computed tomography, photoluminescence, photoacoustic imaging-guided therapies. highlights afterglow eliminate autofluorescence sustained signal emission after excitation.

Язык: Английский

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Activatable Porphyrin-Based Sensors, Photosensitizers and Combination Therapeutics

JACS Au, Год журнала: 2025, Номер unknown

Опубликована: Янв. 15, 2025

Porphyrins, known as the "pigments of life", have evolved from their natural roles into versatile tools for biomedical applications. The development activatable porphyrins has significantly expanded utility, enabling precise responses to a carefully selected target analyte. These advances broadened use in imaging, diagnosis, and therapy. capabilities are driven by activity-based sensing (ABS), which enhances selectivity sensitivity various disease biomarkers. However, design implementation intrinsically complex. This perspective provides an easy-to-follow roadmap that details how such molecules can be developed. Furthermore, we highlight recent progress ABS-modified porphyrins, focusing on specific modifications achieve these remarkable properties across platforms. ongoing evolution holds great promise sophisticated, responsive systems, offering more effective diagnostic therapeutic tools.

Язык: Английский

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A Self‐Sustaining Near‐Infrared Afterglow Chemiluminophore for High‐Contrast Activatable Imaging

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(11)

Опубликована: Янв. 22, 2024

Afterglow imaging holds great promise for ultrasensitive bioimaging due to its elimination of autofluorescence. Self-sustaining afterglow molecules (SAMs), which enable all-in-one photon sensitization, chemical defect formation and generation, possess a simplified, reproducible, efficient superiority over commonly used multi-component systems. However, there is lack SAMs, particularly those with much brighter near-infrared (NIR) emission structural flexibility building high-contrast activatable probes. To address these issues, this study the first time reports methylene blue derivative-based self-sustaining agent (SAN-M) NIR chemiluminescence peaking at 710 nm. By leveraging tunability, an nanoprobe (SAN-MO) customized simultaneously fluoro-photoacoustic peroxynitrite (ONOO

Язык: Английский

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Acidity-activatable upconversion afterglow luminescence cocktail nanoparticles for ultrasensitive in vivo imaging

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Март 8, 2024

Abstract Activatable afterglow luminescence nanoprobes enabling switched “off-on” signals in response to biomarkers have recently emerged achieve reduced unspecific and improved imaging fidelity. However, such always use a biomarker-interrupted energy transfer obtain an activatable signal, which necessitates strict distance requisition between donor acceptor moiety (<10 nm) hence induces low efficiency non-feasibility. Herein, we report organic upconversion cocktail nanoparticles (ALCNs) that instead utilize acidity-manipulated singlet oxygen ( 1 O 2 ) with enlarged thus possess more flexibility signal. After vitro validation of acidity-activated luminescence, ALCNs vivo 4T1-xenograft subcutaneous tumors female mice orthotopic liver male high signal-to-noise ratio (SNR). As representative targeting trial, Bio-ALCNs biotin modification prove the enhanced ability, sensitivity, specificity for pulmonary metastasis tumor via systemic administration mice, also implies potential broad utility diverse design flexibility. Therefore, this study provides innovative general approach better performance than fluorescence imaging.

Язык: Английский

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A NIR‐II‐Emissive Organic Nanomedicine with Biomimetic Engineering for High‐Contrast Targeted Bioimaging and Multiple Phototherapies of Pancreatic Tumors

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Июль 2, 2024

Abstract Recent advances are achieved in the design and development of efficient organic photosensitizers (PSs), especially with fluorescence imaging navigation second near‐infrared (NIR‐II, 1000–1700 nm) region. However, there simply a handful NIR‐II emissive PSs oxygen‐independent capability due to scarcity high‐performance NIR‐responsive materials targeted delivery. Herein, NIR‐II‐emissive nanomedicine biomimetic engineering for multiple phototherapies pancreatic tumors is reported. An A‐D‐A‐type conjugated small‐molecule TPC designed used prepare water‐dispersive nanoparticles, which demonstrated high efficiency type I II photodynamic performances, good photothermal conversion 57%, bright emission quantum yield 9.8% under 808 nm light irradiation. With cancer cell membrane camouflage, high‐resolution bioimaging whole‐body blood vessels tumors. Antitumor experiments tumor elimination biosafety This work versatile enhanced tumor‐targeting superior phototheranostics, providing feasible idea evolution theranostics.

Язык: Английский

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Imaging-guided companion diagnostics in radiotherapy by monitoring APE1 activity with afterglow and MRI imaging

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Июль 27, 2024

Companion diagnostics using biomarkers have gained prominence in guiding radiotherapy. However, biopsy-based techniques fail to account for real-time variations target response and tumor heterogeneity. Herein, we design an activated afterglow/MRI probe as a companion tool dynamically assessing biomarker apurinic/apyrimidinic endonuclease 1(APE1) during radiotherapy vivo. We employ ultrabright afterglow nanoparticles ultrasmall FeMnOx dual contrast agents, significantly broadening signal change range enhancing the sensitivity of APE1 imaging (limit detection: 0.0092 U/mL 0.16 MRI). devise longitudinally transversely subtraction-enhanced (L&T-SEI) strategy markedly enhance MRI signal-to-noise ratio between normal tissue living female mice. The combined facilitate both anatomical functional activity. This enables correlation signals with expression, radiation dosage, intratumor ROS, DNA damage, enabling early prediction outcomes (as 3 h), preceding size reduction (6 days). By monitoring levels, this allows sensitive detection liver organ injury, outperforming histopathological analysis. Furthermore, evaluates expression radiation-induced abscopal effects provides insights into underlying mechanisms, supports development treatment protocols. are promising radiotherapy, but normally detect authors report

Язык: Английский

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Highly Photoreactive Semiconducting Polymers with Cascade Intramolecular Singlet Oxygen and Energy Transfer for Cancer-Specific Afterglow Theranostics

Journal of the American Chemical Society, Год журнала: 2025, Номер unknown

Опубликована: Янв. 10, 2025

Afterglow luminescence provides ultrasensitive optical detection by minimizing tissue autofluorescence and increasing the signal-to-noise ratio. However, due to lack of suitable unimolecular afterglow scaffolds, current agents are nanocomposites containing multiple components with limited performance have rarely been applied for cancer theranostics. Herein, we report synthesis a series oxathiine-containing donor-acceptor block semiconducting polymers (PDCDs) observation their high photoreactivity strong near-infrared (NIR) luminescence. We reveal that PDCDs absorb NIR light undergo photodynamic process generate singlet oxygen (1O2), which intramolecularly transfers efficiently reacts oxathiine form intermediates low Gibbs free energy changes required this photoreaction. Following intramolecular transfer from donor acceptor block, emission is produced PDCDs. Owing efficient cascade photochemical process, PDCD-based nanoparticles achieve higher brightness longer compared most reported agents, even after ultrashort photoirradiation only 3 s. Furthermore, within PDCD can be inhibited bioconjugation quencher-linked peptide. This allows construction cancer-activatable theranostic probe (CATP) switches on signal function in presence cancer-overexpressed enzyme. Thereby, CATP represents first phototheranostic permits cancer-specific therapy under preclinical settings. In summary, study molecular guideline develop probes photoreactive polymers.

Язык: Английский

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Electrostatic Co‐Assembly of Cyanine Pair for Augmented Photoacoustic Imaging and Photothermal Therapy

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Фев. 14, 2025

Abstract Molecular phototheranostic dyes are of eminent interest for oncological diagnosis and imaging‐guided phototherapy. However, it remains challenging to develop photosensitizers (PSs) that simultaneously integrate high‐contrast photoacoustic imaging efficient therapeutic capabilities. In this work, a supramolecular strategy is employed construct molecular pair agent via the direct self‐assembly two cyanines, C5TNa (anionic) Cy‐Et (cationic). The Coulombic interactions between facilitate formation complementary cyanine (C5T‐ET) creation CT‐J‐type aggregates in water. This results completely quenched fluorescence significantly enhances nonradiative deactivation (≈22 ps), leading 3.3‐fold increase photothermal conversion efficiency 7.1‐fold enhancement response compared indocyanine green (ICG). As result, J‐type aggregate demonstrates high capability remarkable antitumor efficacy vivo, highlighting its potential clinical applications. work provides strong experimental evidence superior performance enhancing photosensitization response. It believed will propel advancement controllable dye J‐aggregates contribute practical implementation phototherapy vivo.

Язык: Английский

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Development of time-resolved luminescence measurement instruments for biosensing and bioimaging – An overview

Measurement, Год журнала: 2025, Номер unknown, С. 117201 - 117201

Опубликована: Март 1, 2025

Язык: Английский

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Ratiometric Afterglow Luminescent Imaging of Matrix Metalloproteinase‐2 Activity via an Energy Diversion Process

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(26)

Опубликована: Апрель 19, 2024

Ratiometric afterglow luminescent (AGL) probes are attractive for in vivo imaging due to their high sensitivity and signal self-calibration function. However, there currently few ratiometric AGL available enzymatic activity living organisms. Here, we present an energy diversion (ED) strategy that enables the design of enzyme-activated probe (RAG-RGD) imaging. The ED process provides RAG-RGD with a radiative transition 'always on' 520-nm (AGL

Язык: Английский

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